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Putilina M.V.

Pirogov Russian National Research Medical University

Asthenic disorders as a manifestation of chronic fatigue syndrome

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Putilina M.V.

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To cite this article:

Putilina MV. Asthenic disorders as a manifestation of chronic fatigue syndrome. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(8):125‑130. (In Russ.)
https://doi.org/10.17116/jnevro2021121081125

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References:

  1. Putilina M.V. Asthenic disorders in general medical practice. Diagnostic and therapeutic algorithms. Nervous Diseases. 2013; 4: 26-33. 
  2. International classification of diseases 11 revision of ICD10. https://classinform.ru/mkb-10.html
  3. Young P, Finn BC, Bruetman J, Pellegrini D, Kremer A. Enfoque del síndrome de astenia crónica. The chronic asthenia syndrome: a clinical approach]. Medicina (B Aires). 2010;70(3):284-92. Spanish. PMID: 20529781.
  4. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness. Mil Med. 2015 Jul;180(7):721-3. PMID: 26126237. https://doi.org/10.7205/MILMED-D-15-00085
  5. Aslangul E, Le Jeunne C. Asthénie et fatigabilité [Diagnosing asthenia and chronic fatigue syndrome]. Rev Prat. 2005 May 15;55(9):1029-33. French. PMID: 16052977.
  6. Sapra A, Bhandari P. Chronic Fatigue Syndrome. [Updated 2021 Feb 23]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan.  https://www.ncbi.nlm.nih.gov/books/NBK557676/
  7. Murga Í, Lafuente JV. De la neurastenia a la enfermedad postesfuerzo: evolución de los criterios diagnósticos del síndrome de fatiga crónica/encefalomielitis miálgica [From neurasthenia to post-exertion disease: Evolution of the diagnostic criteria of chronic fatigue syndrome/myalgic encephalomyelitis]. Aten Primaria. 2019 Nov;51(9):579-585. Spanish. https://doi.org/10.1016/j.aprim.2019.04.004
  8. Lim EJ, Ahn YC, Jang ES, Lee SW, Lee SH, Son CG. Systematic review and meta-analysis of the prevalence of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). J Transl Med. 2020 Feb 24;18(1):100.  https://doi.org/10.1186/s12967-020-02269-0
  9. Putilina M.V. Peculiarities of asthenic disorders therapy, neurology and rheumatology. Supplement to the journal Consilicum Medicum, 2010,1: (30-35).
  10. van den Pol AN. Viral infection leading to brain dysfunction: more prevalent than appreciated? Neuron. 2009;64(1):17-20.  https://doi.org/10.1016/j.neuron.2009.09.023
  11. Ortega-Hernandez OD, Shoenfeld Y. Infection, vaccination, and autoantibodies in chronic fatigue syndrome, cause or coincidence? Ann N Y Acad Sci. 2009 Sep;1173:600-9.  https://doi.org/10.1111/j.1749-6632.2009.04799.x
  12. Rasa S, Nora-Krukle Z, Henning N, Eliassen E, Shikova E, Harrer T, Scheibenbogen C, Murovska M, Prusty BK; European Network on ME/CFS (EUROMENE). Chronic viral infections in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). J Transl Med. 2018 Oct 1;16(1):268.  https://doi.org/10.1186/s12967-018-1644-y
  13. Ariza ME. Myalgic Encephalomyelitis / Chronic Fatigue Syndrome: Human Herpes Viruses are Back! Biomolecules. 2021; 11 (2): 185.  https://doi.org/10.3390/biom11020185
  14. Lambert, N. J. & Survivor Corps. COVID-19 “Long Hauler” Symptoms Survey Report. Indiana University School of Medicine; 2020. https://www.survivorcorps.com/reports
  15. Lind K, Hühn MH, Flodström-Tullberg M. Immunology in the clinic review series; focus on type 1 diabetes and viruses: the innate immune response to enteroviruses and its possible role in regulating type 1 diabetes. Clin Exp Immunol. 2012 Apr;168(1):30-8.  https://doi.org/10.1111/j.1365-2249.2011.04557.x
  16. Glassford JA. The Neuroinflammatory Etiopathology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Front Physiol. 2017 Feb 17;8:88.  https://doi.org/10.3389/fphys.2017.00088
  17. Putilina M.V., Vechorko V.I., Grishin D.V., Sidelnikova L.V. Acute cerebrovascular accidents associated with SARS-CoV-2 coronavirus infection (COVID-19). Journal of Neurology and Psychiatry. S.S. Korsakov. 2020;120(12):109–118.  https://doi.org/10.17116/jnevro2020120121109
  18. Wallis A, Ball M, McKechnie S, Butt H, Lewis DP, Bruck D. Examining clinical similarities between myalgic encephalomyelitis/chronic fatigue syndrome and D-lactic acidosis: a systematic review. J Transl Med. 2017 Jun 7;15(1):129.  https://doi.org/10.1186/s12967-017-1229-1
  19. Wostyn P. COVID-19 and chronic fatigue syndrome: Is the worst yet to come? Med Hypotheses. 2021 Jan;146:110469. https://doi.org/10.1016/j.mehy.2020.110469
  20. Cotel F, Exley R, Cragg SJ, Perrier JF. Serotonin spillover onto the axon initial segment of motoneurons induces central fatigue by inhibiting action potential initiation. Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4774-9.  https://doi.org/10.1073/pnas.1216150110
  21. Yamashita M, Yamamoto T. Tryptophan circuit in fatigue: From blood to brain and cognition. Brain Res. 2017 Nov 15;1675:116-126.  https://doi.org/10.1016/j.brainres.2017.09.002
  22. Loebel M, Grabowski P, Heidecke H, Bauer S, Hanitsch LG, Wittke K, Meisel C, Reinke P, Volk HD, Fluge Ø, Mella O, Scheibenbogen C. Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with Chronic Fatigue Syndrome. Brain Behav Immun. 2016 Feb;52:32-39.  https://doi.org/10.1016/j.bbi.2015.09.013
  23. Sotzny F, Blanco J, Capelli E, Castro-Marrero J, Steiner S, Murovska M, Scheibenbogen C; European Network on ME/CFS (EUROMENE). Myalgic Encephalomyelitis/Chronic Fatigue Syndrome — Evidence for an autoimmune disease. Autoimmun Rev. 2018 Jun;17(6):601-609.  https://doi.org/10.1016/j.autrev.2018.01.009
  24. Nalbandian, A., Sehgal, K., Gupta, A. Post-acute COVID-19 syndrome. Nat Med 27, 601–615 (2021). https://doi.org/10.1038/s41591-021-01283-z
  25. Clayton EW. Beyond myalgic encephalomyelitis/chronic fatigue syndrome: an IOM report on redefining an illness. JAMA. 2015 Mar 17;313(11):1101-2.  https://doi.org/10.1001/jama.2015.1346
  26. Jason LA, Sunnquist M. The Development of the DePaul Symptom Questionnaire: Original, Expanded, Brief, and Pediatric Versions. Front Pediatr. 2018 Nov 6;6:330.  https://doi.org/10.3389/fped.2018.00330
  27. Li SH, Sandler CX, Casson SM, Cassar J, Bogg T, Lloyd AR, Barry BK. Randomised controlled trial of online continuing education for health professionals to improve the management of chronic fatigue syndrome: a study protocol. BMJ Open. 2017 May 10;7(5):e014133. https://doi.org/10.1136/bmjopen-2016-014133
  28. Stadje R, Dornieden K, Baum E, Becker A, Biroga T, Bösner S, Haasenritter J, Keunecke C, Viniol A, Donner-Banzhoff N. The differential diagnosis of tiredness: a systematic review. BMC Fam Pract. 2016 Oct 20;17(1):147.  https://doi.org/10.1186/s12875-016-0545-5
  29. Putilina M.V., Baranova O.A. Results of the multicenter clinical and epidemiological observational program “GLOBUS” (determination of the prevalence of dizziness and assessment of therapy regimens at the outpatient level). Journal of Neurology and Psychiatry. S.S. Korsakov. 2014; 114 (5): 33-38. 
  30. Putilina M.V., Risk factors, features of clinical course and treatment approaches in aged patients with cerebral stroke. Korsakov Journal of Neurology and Psychiatry = Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2011;111(5): 90-95. 
  31. Smulevich AB, Kharkova GS, Lobanova VM, Voronova EI. Asteniia v psikhopatologicheskom prostranstve shizofrenii i rasstroĭstv shizofrenicheskogo spektra (kontseptsiia astenicheskogo defekta v aspekte sovremennykh modeleĭ negativnykh rasstroĭstv) [Asthenia in the psychopathological space of schizophrenia and schizophrenia spectrum disorders (The concept of asthenic deficit in aspect of the modern model of negative symptoms)]. Zh Nevrol Psikhiatr Im S S Korsakova. 2019;119(5):7-14. Russian. PMID: 31317883. https://doi.org/10.17116/jnevro20191190517
  32. Strayer DR, Young D, Mitchell WM. Effect of disease duration in a randomized Phase III trial of rintatolimod, an immune modulator for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. PLoS One. 2020 Oct 29;15(10):e0240403. https://doi.org/10.1371/journal.pone.0240403
  33. Kristoffersen EK, Sapkota D, Næss H, Dahl O, Nyland H, Mella O. Benefit from B-lymphocyte depletion using the anti-CD20 antibody rituximab in chronic fatigue syndrome. A double-blind and placebo-controlled study. PLoS One. 2011;6(10):e26358. https://doi.org/10.1371/journal.pone.0026358
  34. Putilina M.V., Ermoshkina N. Yu., Sigitov I.S., Sidelnikova L.V. Progressive multifocal encephalopathy in the practice of a neurologist. Journal of Neurology and Psychiatry. S.S. Korsakov. 2017; 117 (12): 95-105.  https://doi.org/10.17116/jnevro201711712195-105
  35. Putilina M.V. Neuroprotective therapy of chronic cerebral ischemia. Doctor. 2008; 8: 27-32 
  36. Keld Fosgerau, Torsten Hoffmann,Peptide therapeutics: current status and future directions,Drug Discovery Today, 2015:V. 20, Issue 1, 122-128, https://doi.org/10.1016/j.drudis.2014.10.003
  37. Lee, J., Kim, C. Peptide Materials for Smart Therapeutic Applications. Macromol. Res. 29, 2–14 (2021). https://doi.org/10.1007/s13233-021-9011-x
  38. Zhou, X, Smith, QR, Liu, X. Brain-penetrating peptides and peptide-drug conjugates for overcoming the blood-brain barrier and combating diseases of the central nervous system. WIRES Nanomed Nanobiotechnol. 2021 g. ; e1695. https://doi.org/10.1002/wnan.1695
  39. Soudy, R., Kimura, R., Patel, A. Short amylin receptor antagonist peptides improve memory deficits in Alzheimer’s disease mouse model. Sci Rep 9, 10942 (2019). https://doi.org/10.1038/s41598-019-47255-9
  40. Shang N, Meram C, Bandara N, Wu J. Protein and Peptides for Elderly Health. Adv Protein Chem Struct Biol. 2018;112:265-308.  https://doi.org/10.1016/bs.apcsb.2018.03.003
  41. Yakovlev AA, Gulyaeva NV. Molecular partners of cortexin in the brain. Neurochemistry. 2017;33:1:91-96. (In Russ.). https://doi.org/10.1134/S1819712416040164
  42. Nesterenko A.N., Onufriev M.V.,Gulyaeva N.V., Kolosova N.G., Stefanova N.A., Stepanichev M.Yu., Moiseeva Yu.V., Lazareva N.A., Novikova M.R., Peregud D.I. Effect of the drug Cortexin on free radical oxidation and inflammatory processes in rats with normal and accelerated aging. Neurochemistry; 2018, 2(35):187-198.SDI: 007.001.1027-8133.2018.035.002.12]. https://doi.org/10.7868/S1027813318020127
  43. Tsygan V.N. Chronic fatigue syndrome and its correction with Cortexin. Breast cancer; 2010.16: 1004 
  44. Golovina A.G. Cortexin in the complex outpatient therapy of asthenic disorders in adolescents. PSYCHIATRY. 2017; (74): 24-29. 
  45. Instructions for the medical use of the medicinal preparation CORTEXIN. https://grls.rosminzdrav.ru
  46. Putilina M.V., Natarova E.B. Features of manifestations of cerebral circulation insufficiency in young patients. Russian medical news; 2002.1: 41-44. 

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