The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Shvarev E.G.

Astrakhan State Medical University

Dikareva L.V.

Astrakhan State Medical University

Zoeva A.R.

Astrakhan State Medical University

Virus-associated progesterone-resistant chronic endometritis — the oncorisk situation?

Authors:

Shvarev E.G., Dikareva L.V., Zoeva A.R.

More about the authors

Read: 901 times


To cite this article:

Shvarev EG, Dikareva LV, Zoeva AR. Virus-associated progesterone-resistant chronic endometritis — the oncorisk situation? Russian Bulletin of Obstetrician-Gynecologist. 2025;25(1):25‑30. (In Russ.)
https://doi.org/10.17116/rosakush20252501125

Recommended articles:
Stru­ctural and biochemical features of menstrual discharge in patients with uterine fibroids. Russian Bulletin of Obstetrician-Gynecologist. 2024;(6):85-90
Difficulties in life­time diagnosis of Creutzfeldt—Jakob disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):19-27
Clinical case of auri­cular gouty tophi. Russian Bulletin of Otorhinolaryngology. 2024;(6):80-84
Obstructive sleep apnea syndrome as a predictor of atrial fibrillation. Russian Journal of Preventive Medi­cine. 2025;(1):109-114

References:

  1. Shamilova AM, Il’ina IYu, Borovkova EI, Dobrokhotova YuE. Chronic endometritis. Ways to improve diagnostic methods. RMZh. Mat’ i ditya. 2021;3:243-249. (In Russ.). https://doi.org/10.32364/2618-8430-2021-4-3-243-249
  2. Maybin JA, Critchley HOD. Menstrual physiology: implications for endometrial pathology and beyond. Hum Reprod Update. 2015; 21:6:748-761.  https://doi.org/10.1093/humupd/dmv038
  3. Eremichev R, Maria Kulebyakina M, Alexandrushkina M, Nimiritsky P, Basalova N, Grigorieva O, Egiazaryan M, Dyikanov D, Tkachuk V, Makarevich P. Scar-Free healing of endometrium: Tissue-Specific program of stromal cells and its induction by soluble factors produced after samage. Front Cell Dev Biol. 2021;9:616893. https://doi.org/10.3389/fcell.2021.616893
  4. Orazov MR, Mihaleva LM, Mullina IA. Prediction of recurrent endometrial hyperplasia. Review. Trudnyi patsient. 2021;19:7:6-8. (In Russ.).
  5. Bokhman YaV. Guide to gynecological oncology. M.: Kniga po trebovaniyu. 2012:464. (In Russ.).
  6. Li M, Guo T, Cui R, Feng Y, Bai H, Zhang Z. Weight control is vital for patients with early-stage endometrial cancer or complex atypical hyperplasia who have received progestin therapy to spare fertility: a systematic review and meta-analysis. Cancer Manag Res. 2019;11:4005-4021. https://doi.org/10.2147/CMAR.S194607
  7. Serov VN, Tikhomirov AL. Modern principles of therapy of inflammatory diseases of the female genital organs. Methodical manual. Moscow. 2002;24. (In Russ.).
  8. Kazachkov EL, Zatvornitskaya AV, Voropaeva EE, Kazachkova EA, Shchegolev AI. Features of proliferative and antiproliferative activity of endometrial cells in its hyperplasia in combination with chronic endometritis. Akusherstvo i ginekologiya. 2019;8:100-106. (In Russ.).
  9. Qu D, Liu Y, Zhou H, Wang Z. Chronic endometritis increases the recurrence of endometrial polyps in premenopausal women after hysteroscopic polypectomy. BMC Womens Health. 2023;23:1:88.  https://doi.org/10.1186/s12905-023-02232-3
  10. Kitaya K, Yasuo T. Commonalities and disparities between endometriosis and chronic endometritis: Therapeutic potential of novel antibiotic treatment strategy against ectopic endometrium. Int J Mol Sci. 2023;24:3:2059. https://doi.org/10.3390/ijms24032059
  11. Zarochentseva NV, Arshakyan AK, Men’shikova NS, Titchenko YuP. Chronic endometritis: etiology, clinical picture, diagnosis, treatment. Russian Bulletin of Obstetrician-Gynecologist. 2013; 13:5:21-27. (In Russ.).
  12. Kazachkova EA, Zatvornitskaya AV, Voropaeva EE, Kazachkov EL. Endometrial hyperplasia combined with chronic endometritis: clinical and morphological features. Ural’skii meditsinskii zhurnal. 2020;3:36-41. (In Russ.).
  13. Agostinis C, Mangogna A, Bossi F, Ricci G, Kishore U, Bulla R. Uterine immunity and microbiota: A Shifting paradigm. Front Immunol. 2019;10:2387. https://doi.org/10.3389/fimmu.2019.02387
  14. Metlitskaya MA, Rogov YuI. Analysis of the incidence of papillomavirus infection in endometrial hyperplastic processes and adenocarcinomas. Meditsinskie novosti. 2012;12:78-79. (In Russ.).
  15. Orazov MR, Radzinskii VE, Volkova SV, Khamoshina MB, Mikhaleva LM, Abitova MZ, Shustova V.B. Chronic endometritis in women with endometriosis-associated infertility. Ginekologiya. 2020;22:3:15-20. (In Russ.).
  16. Mlodzik N, Lukaszuk K, Sieg W, Jakiel G, Smolarczyk R. Endometrial microbiota — do they mean more than we have expected? Ginekol Pol. 2020;91:1:45-48.  https://doi.org/10.5603/GP.2020.0010
  17. Olesen TB, Svahn MF, Faber MT, Duun-Henriksen AK, Junge J, Norrild B, Kjaer SK. Prevalence of Human Papillomavirus in endometrial cancer: a systematic review and meta-analysis. Gynecol Oncol. 2014;134:1:206-215.  https://doi.org/10.1016/j.ygyno.2014.02.040
  18. Castle PE, Locke A, Tergas AI, Befano B, Poitras N, Shah NR, Schiffman M, Wentzensen N, Strickler HD, Clarke MA, Lorey T. The relationship of human papillomavirus and cytology co-testing results with endometrial and ovarian cancer diagnoses. Gynecol Oncol. 2021;161:1:297-303.  https://doi.org/10.1016/j.ygyno.2021.01.005
  19. Gautam H, Mehta S, Nayar N, Kumar N, Husain SA, Bharadwaj M. Prevalence of human papillomavirus and Chlamydia trachomatis in endometrial and cervical carcinoma: a comparative study in North Indian women. Syst Biol Reprod Med. 2023;5:1-11.  https://doi.org/10.1080/19396368.2023.2247517
  20. Grabarek BO, Ossowski P, Czarniecka J, Ożóg M, Prucnal J, Dziuba I, Ostenda A, Dziobek K, Boroń D, Peszek W, Kras P, Januszyk S, Dąbala M, Kasela T, Opławski M. Detection and Genotyping of Human Papillomavirus (HPV16/18), Epstein-Barr Virus (EBV), and Human Cytomegalovirus (HCMV) in endometrial endometroid and ovarian cancers. Pathogens. 2023;12:3:397.  https://doi.org/10.3390/pathogens12030397
  21. Unanyan AL, Sidorova IS, Kossovich YuM, Kogan EA, Demura TA. Chronic endometritis and HPV: alarming news. The role of the combination of HPV infection and chronic endometritis in the pathogenesis of malignant endometrial tumors. StatusPraesens. 2012;3:21-25. (In Russ.).
  22. Sukhikh GT, Shurshalina AV. Chronic endometritis. A guide. Moscow: GEOTAR-Media. 2013;64. (In Russ.).
  23. Al-Sabbagh M, Lam EW, Brosens J. Mechanisms of endometrial progesterone resistance. J Mol Cell Endocrinol. 2012;358:2:208-215.  https://doi.org/10.1016/j.mce.2011.10.035
  24. Lyzikova YuA. Features of the production and reception of sex hormones in patients with chronic endometritis. Akusherstvo i ginekologiya. 2020;12:144-148. (In Russ.). https://doi.org/10.18565/aig.2020.12.144-148
  25. Russo M, Newell JM, Budurlean L, Houser KR, Sheldon K, Kesterson J, Phaeton R, Hossler C, Rosenberg J, DeGraff D, Shuman L, Broach JR, Warrick JI. Mutational profile of endometrial hyperplasia and risk of progression to endometrioid adenocarcinoma. Cancer. 2020;126:12:2775-2783. https://doi.org/10.1002/cncr.32822
  26. Jeong O, Broaddus RR, Lessey BA, Risinger JI, Hunter MI, Kim TH. MIG-6 is critical for progesterone responsiveness in human complex atypical hyperplasia and early-stage endometrial cancer. Int J Mol Sci. 2022;23:23:14596. https://doi.org/10.3390/ijms232314596
  27. Baracat MCP, Baracat EC, Simões RS, Simões MJ, Maciel GAR, Azziz R, Soares Jr JM. Hormonal and metabolic factors influence the action of progesterone on the endometrium of women with polycystic ovary. Syndrome Diagnostics (Basel). 2023;13:3:382.  https://doi.org/10.3390/diagnostics13030382
  28. Pu H, Wen X, Luo D, Guo Z. Regulation of progesterone receptor expression in endometriosis, endometrial cancer, and breast cancer by estrogen, polymorphisms, transcription factors, epigenetic alterations, and ubiquitin-proteasome system. J Steroid Biochem Mol Biol. 2023;227:106199. https://doi.org/10.1016/j.jsbmb.2022.106199
  29. Dobrokhotova YuE, Yakubova KK. Microbiota of the reproductive tract and hyperplastic processes of the endometrium (review). RMZh «Meditsinskoe obozrenie». 2018;10:14-16. (In Russ.).
  30. Puente E, Alonso L, Laganà AS, Ghezzi F, Casarin J, Carugno J. Chronic endometritis: Old problem, novel insights and future challenges. Int J Fertil Steril. 2020;13:4:250-256.  https://doi.org/10.22074/ijfs.2020.5779
  31. Travaglino A, Raffone A, Gencarelli A, Micheli M, Franco L, Zullo F, Mollo A, Di Spiezio Sardo A, Bifulco G, Insabato L. Dusp6 immunohistochemistry is associated with the response of atypical endometrial hyperplasia and early endometrial cancer to conservative treatment. Int J Gynaecol Obstet. 2022;158:3:742-747. 
  32. Vitale SG, Buzzaccarini G, Riemma G, Pacheco LA, Sardo A. Di S., Carugno J, Chiantera V, Török P, Noventa M, Haimovich S, De Franciscis P,A, Angioni S, Laganà AS. Endometrial biopsy: Indications, techniques and recommendations. An evidence-based guideline for clinical practice. J Gynecol Obstet Hum Reprod. 2023;52:6:102588. https://doi.org/10.1016/j.jogoh.2023.102588
  33. Ng JKM, Cheung BHC, Lee DHY, Li JJX, Ip PPC, Lee JHS, Yeung CSY, Yu MY. Detection rates and factors affecting there of in endometrial hyperplasia, endometrial carcinoma, and cervical glandular lesions on cervical smear. Cancer Med. 2023;12:17:17581-17591. https://doi.org/10.1002/cam4.6376
  34. Tapil’skaya NI, Gzgzyan AM, Kogan IYu. The hidden causes of reproductive failure. Viral infections in the development of chronic endometritis. Status Praesens. Akusherstvo, ginekologiya, besplodnyi brak. 2019;4:59:118-124. (In Russ.).
  35. Lv M, Chen P, Bai M, Huang Y, Li L, Feng Y, Liao H, Zheng W, Chen X, Zhang Zh. Progestin resistance and corresponding management of abnormal endometrial hyperplasia and endometrial carcinoma. Cancers (Basel). 2022;14:24:6210. https://doi.org/10.3390/cancers14246210
  36. Hewitt SC, Dickson MJ, Edwards N, Hampton K, Garantziotis S, DeMayo FJ. From cup to dish: how to make and use endometrial organoid and stromal cultures derived from menstrual fluid. Front Endocrinol (Lausanne). 2023;14:1220622. https://doi.org/10.3389/fendo.2023.1220622
  37. Tatarinov YuS., Posiseeva LV, Petrunin DD. Specific alpha2-microglobulin (glycodelin) of the human reproductive system: 20 years from basic research to implementation in clinical practice. M.-Ivanovo: MIK. 1998. (In Russ.).
  38. Posiseeva LV, Gerasimov AM, Petrova UL. Glycodelin in obstetric and gynecological practice: past, present, future. Russian Journal of Human Reproduction. 2020;26:3:11-22. (In Russ.). https://doi.org/10.17116/repro20202603111
  39. Waites GT, Bell SC. Immunohistological localization of human pregnancy-associated endometrial alpha-2 globulin (alpha-2 PEG), a glycosylated-lactoglobulin homologue, in the decidua and placenta during pregnancy. J Reprod Fertil. 1989;87:1:291-300. 
  40. Olena O. Taranovska, Volodymyr K. Likhachov, Ludmyla M. Dobrovolska, Oleg G. Makarov, Yanina V. Shymanska. Possibility for non-invasive diagnosis of chronic endometritis in women at risk during pregravid preparation. Wiad Lek. 2019;72:1:64-67. 
  41. Boltovskaya MN, Starosvetskaya NA. Glycodelin as a potential marker for tumors of the female reproductive system. Arkhiv patologii. 2008;4:51-55. (In Russ.).
  42. Tatarinov YuS, Sherbakova LA, Olefirenko GA, Petrunin DD. Protein factor of fertility in malignancies. Tumor Biology. 1990;11:3:113-119. 
  43. Kolesnichenko AA, Petrov YuA. Chronic endometritis and miscarriage. Mezhdunarodnyi zhurnal prikladnykh i fundamental’nykh issledovanii. 2019;10:2:313-317. (In Russ.). https://doi.org/10.17513/mjpfi.2019.10.2
  44. Seppälä M, Taylor RN, Koistinen H, Koistinen R, Milgrom E. Glycodelin: a major lipocalin protein of the reproductive axis with diverse actions in cell recognition and differentiation. Endocr Rev. 2002;23:4:401-430.  https://doi.org/10.1210/er.2001-0026
  45. Koistinen H, Seppälä M, Nagy B, Tapper J, Knuutila S, Koistinen R. Glycodelin reduces carcinoma-associated gene expression in endometrial adenocarcinoma cells. Am J Obstet Gynecol. 2005;193:6:1955-1960. https://doi.org/10.1016/j.ajog.2005.05.073
  46. Cui J, Liu Y, Wang X. The Roles of glycodelin in cancer development and progression. Front Immunol. 2017 29;8:1685. https://doi.org/10.3389/fimmu.2017.01685
  47. Song M, Ramaswamy S, Ramachandran S, Flowers LC, Horowitz IR, Rock JA, Parthasarathy S. Angiogenic role for glycodelin in tumorigenesis. Proc Natl Acad Sci USA. 2001;98:16:9265-9270. https://doi.org/10.1073/pnas.151151198
  48. Polishchuk LZ, Shvarev EG, Volodin MA, Ganina KP. Morphofunctional assessment of endometrial cancer hormone sensitivity during progestogen treatment. Guidelines. Kiev. 1991. (In Russ.).

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.