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Kamaev A.A.

Ryazan State Medical University named after academician I.P. Pavlov

Kalinin R.E.

Pavlov Ryazan State Medical University

Pshennikov A.S.

Ryazan State Medical University named after academician I.P. Pavlov

Suchkov I.A.

Pavlov Ryazan State Medical University

Effect of Micronized Purified Flavonoid Fraction on Vein-Specific Inflammatory Markers in Patients with Varicose Veins Disease

Authors:

Kamaev A.A., Kalinin R.E., Pshennikov A.S., Suchkov I.A.

More about the authors

Journal: Journal of Venous Disorders. 2025;19(4): 273‑283

DOI: 10.17116/flebo202519041273

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Table of contents

EFFECT OF MICRONIZED PURIFIED FLAVONOID FRACTION ON VEIN-SPECIFIC INFLAMMATORY MARKERS IN PATIENTS WITH VARICOSE VEINS DISEASE
EFFECT OF MICRONIZED PURIFIED FLAVONOID FRACTION ON VEIN-SPECIFIC INFLAMMATORY MARKERS IN PATIENTS WITH VARICOSE VEINS DISEASE

To cite this article:

Kamaev AA, Kalinin RE, Pshennikov AS, Suchkov IA. Effect of Micronized Purified Flavonoid Fraction on Vein-Specific Inflammatory Markers in Patients with Varicose Veins Disease. Journal of Venous Disorders. 2025;19(4):273‑283. (In Russ.)
https://doi.org/10.17116/flebo202519041273

Подписка 2026 Флебология (Journal of Venous Disorders)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To evaluate the effect of micronized purified flavonoid fraction (MPFF) on vein-inflammatory markers (E-selectin, MCP-1, VEGF, MMP-2, MMP-9) and quality of life in patients with varicose veins, including combination with endovenous laser ablation (EVLA).

MATERIAL AND METHODS

A prospective study included 186 patients with varicose veins of clinical classes C2—C6 (CEAP), divided into four groups: group 1 used compression hosiery; group 2 received MPFF 1000 mg daily; group 3 underwent EVLA; group 4 received MPFF after EVLA. Biomarkers were measured before treatment, at 2 months, and at 12 months. Adverse events were recorded. Changes in quality of life were assessed using the CIVIQ-20 and SF-36 questionnaires.

RESULTS

At 2 months follow-up there was a significant reduction in E-selectin, MCP-1, and VEGF (p<0.001) in the MPFF group. Effect on MCP-1 and VEGF sustained up to 12 months in C2—C3 patients. MMP-2 and MMP-9 levels showed no significant change. After EVLA, there was a short-term decrease in E-selectin, MCP-1, and MMP-2. The most pronounced effects were observed in the EVLA+MPFF group: MCP-1 decreased by 46.2% at 2 months and 40.7% at 12 months; VEGF decreased by up to 52% (C2—C3) and 44.4% (C4—C6); E-selectin decreased by 36.2 and 29.9%, respectively. Quality of life improvement was greatest in the EVLA+MPFF group and persisted up to 12 months. No significant changes were registered in the compression group.

CONCLUSIONS

MPFF exerts an anti-inflammatory effect, particularly in early-stage disease (C2—C3). The combination of EVLA and MPFF provides the most substantial and sustained reduction in inflammatory markers and the best quality-of-life outcomes. In advanced stages (C4—C6), prolonged pharmacotherapy is advisable.

Keywords:

vein-specific inflammation
micronized purified flavonoid fraction
endovenous laser ablation
quality of life
varicose vein disease

Authors:

Kamaev A.A.

Ryazan State Medical University named after academician I.P. Pavlov

Kalinin R.E.

Pavlov Ryazan State Medical University

Pshennikov A.S.

Ryazan State Medical University named after academician I.P. Pavlov

Suchkov I.A.

Pavlov Ryazan State Medical University

Received:

26.09.2025

Accepted:

25.10.2025

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References:

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