OBJECTIVE

To create a method for modeling of varicose veins in dogs in a chronic experiment.

MATERIAL AND METHODS

The experiment was carried out on 15 sexually mature mongrel uncastrated male dogs weighing 15.000—17.000 g divided into 3 groups: group I (control) — human chorionic gonadotropin 200 U/kg and progesterone 1% 0.1 ml/kg intramuscularly; group II — hexestrol 0.09 mg/kg and progesterone 1% 0.1 ml /kg intramuscularly; group III — progesterone 1% 0.1 ml /kg intramuscularly. The drugs were administered 1 day before surgery. Then, we narrowed femoral vein in the upper third of the thigh under combined anesthesia. Intramuscular administration of the above-mentioned drugs was continued after surgery and for the next 6 days. Monitoring of ultrasound parameters and laboratory data (leukocytes, CRP, IL-6) was performed 1 day before surgery, after 10 and 30 days.

RESULTS

Femoral vein narrowing by ½ combined with progesterone and estrogen leads to staged development of varicose disease with persistent irreversible manifestations. Unlike groups 1 and 3, this combination is less associated with inflammatory response.

CONCLUSION

A method for modeling of varicose veins in a chronic experiment was created.