Currently, the research of the pathogenetic mechanisms of the chronification of the demyelinating after the development of an acute demyelination episode (ADE) remains an urgent issue. An important role in maintaining autoimmune inflammation in the central nervous system is played by proinflammatory cytokines and proteins of the acute phase of inflammation, among which interleukin-1β (IL-1β), interleukin-6 (IL-6) and C-reactive protein (CRP) are distinguished.

THE AIM OF THE STUDY

Is to estimate the levels of IL-1β, IL-6 and CRP in the blood plasma of patients with ADE and in the control group.

MATERIAL AND METHODS

The study are included 15 patients with ADE in the medical history (n=15): 5 patients in the acute period of the disease (patients with acute disseminated encephalomyelitis (ADEM) or myelitis before corticosteroids therapy), and 10 patients in remission. Patients from the control group were comparable in number, age and gender with the main group of patients. The levels of IL-1β, IL-6 and CRP were assessed by enzyme-linked immunosorbentassay (ELISA) with further evaluation of obtained results.

RESULTS

A comparative analysis of the levels of IL-1β, IL-6 and CRP in the group of patients with ADE and in the control group revealed no significant statistically significant differences. However, among patients with ADE in their medical history the level of IL-1β was statistically higher than among the patients in remission. The highest level of IL-1β in the blood plasma was noticed in blood plasma of the patient with myelitis, which was the first clinical manifestation of neuromyelitis optica spectrum disorders (NMOSD).

CONCLUSION

The preliminary results of the study do not allow us to unambiguously conclude that the levels of proinflammatory cytokines and CRP are related to the activity of the demyelinating in patients with ADE, which is probably due to the small sample and the time of their observation.