Relationship between oxidative stress patterns and proinflammatory cytokines in patients with polypous rhinosinusitis under the course of therapeutic physical factors

Nagornev S.N.; Pelishenko T.G.; Koryagin F.N.

doi:https://doi.org/10.17116/rbpdpm2025202142

Nagornev S.N.

Petrovsky National Research Center of Surgery

SPIN RSCI: 2099-3854
ORCID: 0000-0002-1190-1440

Pelishenko T.G.

Clinical Hospital No. 1 of the Presidential Administration

ORCID: 0000-0001-6597-2167

Koryagin F.N.

Clinical Hospital No. 1 of the Presidential Administration of the Russian Federation

ORCID: 0000-0002-0603-9059

Relationship between oxidative stress patterns and proinflammatory cytokines in patients with polypous rhinosinusitis under the course of therapeutic physical factors

Authors:

Nagornev S.N., Pelishenko T.G., Koryagin F.N.

More about the authors

Journal: Regenerative Biotechnologies, Preventive, Digital and Predictive Medicine. 2025;2(2): 42‑49

DOI: 10.17116/rbpdpm2025202142

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To cite this article:

Nagornev SN, Pelishenko TG, Koryagin FN. Relationship between oxidative stress patterns and proinflammatory cytokines in patients with polypous rhinosinusitis under the course of therapeutic physical factors. Regenerative Biotechnologies, Preventive, Digital and Predictive Medicine. 2025;2(2):42‑49. (In Russ.)
https://doi.org/10.17116/rbpdpm2025202142

Подписка 2026 Восстановительные биотехнологии, профилактическая, цифровая и предиктивная медицина (Regenerative Biotechnologies, Preventive, Digital and Predictive Medicine)

Использование инфографики авторами научных работ

OBJECTIVE

To analyze cytokine profile and oxidative stress markers in patients with polypous rhinosinusitis under LILI and MDM therapy combined with dupilumab.

MATERIAL AND METHODS

The study included 128 patients with moderate, severe and uncontrollable course of polypous rhinosinusitis. All patients received basic therapy with mometasone 2 doses 2 times a day and daily washing of nasal mucosa with saline. All patients were randomized into 4 groups: group 1 (control, n=32) — BT alone; group 2 (comparison group 1, n=32) — additional dupilumab 300 mg subcutaneously daily every two weeks; group 3 (comparison group 2, n=32) — low-intensity laser irradiation (LILI) along with BT and dupilumab; group 4 (main, n=32) — LILI and MDM therapy in addition to dupilumab. Clinical efficacy was assessed considering nasal polyposis severity (Lund-Mackay and Meltzer scales) and QoL (SNOT-22 questionnaire). Changes in cytokine status were determined considering serum proinflammatory interleukins (IL-4, IL-5, IL-13). IgE and eosinophilic cationic protein were additionally studied. Analysis of oxidative stress implied assessment of lipid peroxidation products and activity of antioxidant enzymes. Clinical and laboratory status was assessed before treatment, 1 and 6 months after therapy.

RESULTS

We observed pathogenetic role of proinflammatory interleukins (IL-4; -5; -13) and oxidative stress patterns for nasal polyposis. High activity of dupilumab in blocking the expression of IL-4 and IL-13 was established. Additional physical factors increase inhibitory effect on proinflammatory mediators, as well as reduce accumulation of lipid peroxidation products. The relationship between oxidative stress patterns and activity of proinflammatory cytokines in pathogenesis of polypous rhinosinusitis was presented.

CONCLUSION

The relationship between oxidative stress markers and proinflammatory protein factors proves their ability to mutually reinforce each other and contribute to chronic inflammatory process in nasal cavity. Therapeutic physical factors (LILI and MDM) combined with dupilumab are accompanied by suppression of trigger mechanism of type 2 inflammation and reduce accumulation of primary and secondary lipid peroxidation products.

Keywords:

low-intensity laser irradiation

mesodiencephalic modulation

dupilumab

polypous rhinosinusitis

oxidative stress

proinflammatory cytokines

Authors:

Nagornev S.N.

Petrovsky National Research Center of Surgery

SPIN RSCI: 2099-3854
ORCID: 0000-0002-1190-1440

Pelishenko T.G.

Clinical Hospital No. 1 of the Presidential Administration

ORCID: 0000-0001-6597-2167

Koryagin F.N.

Clinical Hospital No. 1 of the Presidential Administration of the Russian Federation

ORCID: 0000-0002-0603-9059

Received:

19.03.2025

Accepted:

26.04.2025

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References:

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