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Masolitin S.V.

Pirogov Moscow City Clinical Hospital No 1;
Pirogov Russian National Research Medical University

Protsenko D.N.

«Kommunarka» Moscow Multidisciplinary Clinical Center of the Moscow City Healthcare Department;
N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia

Magomedov M.A.

Pirogov Moscow City Clinical Hospital No 1;
Pirogov Russian National Research Medical University

Shifman E.M.

Pirogov National Research Medical University

Grishina L.A.

Pirogov City Clinical Hospital No. 1

Kolerova I.V.

Pirogov City Clinical Hospital No. 1

Abdullin E.T.

Chazov National Medical Research Center of Cardiology

Pokrovsky N.S.

Chazov National Medical Research Center of Cardiology

Losev D.V.

Pirogov Moscow City Clinical Hospital No 1

Kalinin E.Yu.

Pirogov Moscow City Clinical Hospital No 1

Experience with selective plasmosorption of cfDNA/NETs in a patient with severe acute pancreatitis (case report)

Authors:

Masolitin S.V., Protsenko D.N., Magomedov M.A., Shifman E.M., Grishina L.A., Kolerova I.V., Abdullin E.T., Pokrovsky N.S., Losev D.V., Kalinin E.Yu.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2025;(4): 87‑94

DOI: 10.17116/anaesthesiology202504187

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Table of contents

EXPERIENCE WITH SELECTIVE PLASMOSORPTION OF CFDNA/NETS IN A PATIENT WITH SEVERE ACUTE PANCREATITIS (CASE REPORT)
EXPERIENCE WITH SELECTIVE PLASMOSORPTION OF CFDNA/NETS IN A PATIENT WITH SEVERE ACUTE PANCREATITIS (CASE REPORT)

To cite this article:

Masolitin SV, Protsenko DN, Magomedov MA, et al. . Experience with selective plasmosorption of cfDNA/NETs in a patient with severe acute pancreatitis (case report). Russian Journal of Anesthesiology and Reanimatology. 2025;(4):87‑94. (In Russ.)
https://doi.org/10.17116/anaesthesiology202504187

МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

BACKGROUND

Modality, timing and duration of extracorporeal detoxification (ECD) in patients with severe acute pancreatitis are a controversial and unsolved problem.

OBJECTIVE

To evaluate safety, clinical and laboratory effectiveness of selective plasmosorption (SP) in a patient with severe acute pancreatitis.

MATERIAL AND METHODS

A 34-year-old patient presented with severe acute pancreatitis complicated by enzymatic shock. Clinical, laboratory and instrumental diagnostic methods were performed. Cell-free deoxyribonucleic acid (cfDNA) SP was used together with standard intensive therapy. The main laboratory parameters were compared.

RESULTS

SP significantly reduced the markers of systemic endogenous intoxication: CRP from 64.3 to 29.5 mg/l (54.12%) by the 4th day; leukocytes from 16.2 to 7.8∙109/l (51.85%); IL-1 from 224.1 to 16.7 pg/ml (92.55%); IL-6 from 423.4 to 84.4 pg/ml (80.1%); TNF-α from 627.2 to 102.6 pg/ml (83.64%); cfDNA from 2270 to 10 ng/ml (99.56%), band neutrophils from 18% to 11% (33.89%) by the 7th day. Acid-base state normalized by the 3rd day (pH from 7.15 to 7.31, BE from –11.2 to –2.6, lactate from 4.9 to 1.4 mmol/l). SOFA scores decreased from 6 to 1 point by the 7th day.

CONCLUSION

SP of cfDNA quickly normalizes the main clinical and laboratory parameters, as well as markers of systemic endogenous intoxication.

Keywords:

acute pancreatitis
systemic endogenous intoxication syndrome
selective plasmosorption
cell free DNA
interleukin-1
interleukin-6
tumor necrosis factor-alpha

Authors:

Masolitin S.V.

Pirogov Moscow City Clinical Hospital No 1;
Pirogov Russian National Research Medical University

Protsenko D.N.

«Kommunarka» Moscow Multidisciplinary Clinical Center of the Moscow City Healthcare Department;
N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia

Magomedov M.A.

Pirogov Moscow City Clinical Hospital No 1;
Pirogov Russian National Research Medical University

Shifman E.M.

Pirogov National Research Medical University

Grishina L.A.

Pirogov City Clinical Hospital No. 1

Kolerova I.V.

Pirogov City Clinical Hospital No. 1

Abdullin E.T.

Chazov National Medical Research Center of Cardiology

Pokrovsky N.S.

Chazov National Medical Research Center of Cardiology

Losev D.V.

Pirogov Moscow City Clinical Hospital No 1

Kalinin E.Yu.

Pirogov Moscow City Clinical Hospital No 1

Received:

23.08.2024

Accepted:

27.01.2025

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