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Zakharova M.N.

Research Center of Neurology

Simaniv T.O.

Research Center of Neurology

Sapozhnikov K.V.

S.M. Kirov Military Medical Academy

Tolkacheva D.G.

The North-West Institute of Management of the Russian Presidential Academy of National Economy and Public Administration

Sokolova V.D.

Health Economics Group School of Public Health and Preventive Medicine Monash University

Sableva N.A.

The North-West Institute of Management of the Russian Presidential Academy of National Economy and Public Administration

Mironenko O.N.

The North-West Institute of Management of the Russian Presidential Academy of National Economy and Public Administration

Lazarev A.A.

Bonch-Bruevich Saint Petersburg State University of Telecommunications

Khimich T.V.

The North-West Institute of Management of the Russian Presidential Academy of National Economy and Public Administration

Comparing the efficacy of divozilimab and second-line treatments for relapsing-remitting multiple sclerosis in the Russian Federation: a systematic review and network meta-analysis

Authors:

Zakharova M.N., Simaniv T.O., Sapozhnikov K.V., Tolkacheva D.G., Sokolova V.D., Sableva N.A., Mironenko O.N., Lazarev A.A., Khimich T.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(2): 58‑68

DOI: 10.17116/jnevro202512502158

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Table of contents

COMPARING THE EFFICACY OF DIVOZILIMAB AND SECOND-LINE TREATMENTS FOR RELAPSING-REMITTING MULTIPLE SCLEROSIS IN THE RUSSIAN FEDERATION: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS
COMPARING THE EFFICACY OF DIVOZILIMAB AND SECOND-LINE TREATMENTS FOR RELAPSING-REMITTING MULTIPLE SCLEROSIS IN THE RUSSIAN FEDERATION: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS

To cite this article:

Zakharova MN, Simaniv TO, Sapozhnikov KV, et al. Comparing the efficacy of divozilimab and second-line treatments for relapsing-remitting multiple sclerosis in the Russian Federation: a systematic review and network meta-analysis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(2):58‑68. (In Russ.)
https://doi.org/10.17116/jnevro202512502158

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To compare efficacy of the new drug divozilimab with other second-line treatment options for relapsing remitting multiple sclerosis (RRMS) that have been already included or submitted application to be included into the «14 high-cost nosologies» program in the Russian Federation.

MATERIAL AND METHODS

We conducted systematic literature review (PROSPERO ID CRD42022310082) and frequentist network meta-analysis of 2-years efficacy of divozilimab and other second-line therapies to treat RRMS.

RESULTS

Annualized relapse rate ratio in divozilimab vs fingolimod was 0.4 (95% CI 0.3—0.7), divozilimab vs cladribin 0.5 (95% CI 0.3—0.9), divozilimab vs alemtuzumab 0.7 (95% CI 0.3—1.7), divozilimab vs ocrelizumab 0.7 (95% CI 0.3—1.6), divozilimab vs ofatumumab 0.7 (95% CI 0.4—1.1), divozilimab vs natalizumab 0.4 (95% CI 0.4—1.1) respectively. Divozilimab had the highest SUCRA rank (0.9) while fingolimod had the lowest (0.4).

CONCLUSION

Systematic literature review and network meta-analysis revealed statistically significant superiority of divozilimab over cladribine and fingolimod and absence of statistically significant differences with alemtuzumab, ocrelizumab, ofatumumab and natalizumab in the annual relapse rate during 2 years of treatment.

Keywords:

multiple sclerosis
divozilimab
efficacy
systematic review
network meta-analysis
indirect comparisons

Authors:

Zakharova M.N.

Research Center of Neurology

Simaniv T.O.

Research Center of Neurology

Sapozhnikov K.V.

S.M. Kirov Military Medical Academy

Tolkacheva D.G.

The North-West Institute of Management of the Russian Presidential Academy of National Economy and Public Administration

Sokolova V.D.

Health Economics Group School of Public Health and Preventive Medicine Monash University

Sableva N.A.

The North-West Institute of Management of the Russian Presidential Academy of National Economy and Public Administration

Mironenko O.N.

The North-West Institute of Management of the Russian Presidential Academy of National Economy and Public Administration

Lazarev A.A.

Bonch-Bruevich Saint Petersburg State University of Telecommunications

Khimich T.V.

The North-West Institute of Management of the Russian Presidential Academy of National Economy and Public Administration

Received:

05.02.2025

Accepted:

07.02.2025

Close metadata

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