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Belova A.N.
Privolzhsky Research Medical University
Ruina E.A.
Privolzhsky Research Medical University
Kukushkina A.D.
Zhadkevich City Clinical Hospital;
Pirogov Russian National Research Medical University
Boyko A.N.
Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies
The diagnostic effectiveness of criteria for neuromyelitis optica spectrum disorders in the Russian clinical practice
Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(7‑2): 16‑25
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To cite this article:
Belova AN, Sheiko GE, Ruina EA, et al. . The diagnostic effectiveness of criteria for neuromyelitis optica spectrum disorders in the Russian clinical practice. S.S. Korsakov Journal of Neurology and Psychiatry.
2024;124(7‑2):16‑25. (In Russ.)
https://doi.org/10.17116/jnevro202412407216
To compare the diagnostic criteria of 2006 (DC 2006) and 2015 (DC 2015) in the Russian population of patients with suspected neuromyelitis optica spectrum disorders (NMOSD), with the calculation of their sensitivity, specificity, accuracy and predictive value.
We reviewed medical records of suspected NMOSD patients who were therefore examined for the presence of serum autoantibodies targeting the aquaporin-4 water channel protein (AQP4-IgG) in 6 specialized Russian (Nizhny Novgorod and Moscow) medical centers. One hundred patients (78 female), aged 17 to 74 years (mean 38.1±13.3 years), were included. The follow-up period ranged from 4 to 108 months (mean 59.7±31.6 months).
During the follow-up the diagnosis of NMOSD was confirmed in 32 people, and 68 patients had diagnoses different from NMOSD. At the disease onset, 68.8% of patients were seropositive for AQP4-IgG. The mean time for confirming NMOSD diagnosis was 15.2±14.2 months. At the disease onset, 36% of patients fulfilled the DC 2015, the diagnosis was subsequently confirmed in 77.8% out of them. 26% of the patients fulfilled the DC 2006, the diagnosis was subsequently confirmed in 84.6% out of them. The sensitivity of DC 2006/DC 2015 was 69%/88%, specificity 94%/88%, accuracy 86%/88%, negative predictive value 85%/94%, positive predictive value 86%/78%.
The specificity, sensitivity and accuracy of modern diagnostic criteria for NMOSD In Russian patients is comparable to those obtained in foreign studies. DC 2015 helps to diagnose NMOSD earlier than DC 2006, but they have a lower specificity.
Keywords:
Authors:
Belova A.N.
Privolzhsky Research Medical University
Ruina E.A.
Privolzhsky Research Medical University
Kukushkina A.D.
Zhadkevich City Clinical Hospital;
Pirogov Russian National Research Medical University
Boyko A.N.
Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies
Received:
24.04.2024
Accepted:
25.04.2024
List of references:
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