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Berezutsky M.A.

Razumovsky Saratov State Medical University

Durnova N.A.

Razumovsky Saratov State Medical University

Andronova T.A.

Razumovsky Saratov State Medical University

Ginkgolide B: mechanisms of neurobiological effects, prospects for use in the therapy of Alzheimer’s disease

Authors:

Berezutsky M.A., Durnova N.A., Andronova T.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(4): 22‑27

DOI: 10.17116/jnevro202412404122

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Berezutsky MA, Durnova NA, Andronova TA. Ginkgolide B: mechanisms of neurobiological effects, prospects for use in the therapy of Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(4):22‑27. (In Russ.)
https://doi.org/10.17116/jnevro202412404122

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The review presents an analysis of experimental data on the study of neurobiological effects of ginkgolide B, which may find application in the therapy of Alzheimer’s disease (AD). Ginkgolide B is a diterpene trilactone isolated from the leaves of the relict woody plant Ginkgo biloba L., which has been used for thousands of years in traditional Chinese medicine as a neuroprotective agent. In recent years, this compound has attracted attention because of its wide range of neurobiological effects. The neuroprotective effect of ginkgolide B on brain neurons when exposed to various neurotoxins has been established. This compound has also been shown to effectively protect neurons from the effects of beta-amyloid. Studies have revealed the ability of ginkgolide B to reduce microglia activity and regulate neurotransmitter release. In vivo experiments have shown that this substance significantly increases the expression of brain-derived neurotrophic factor (BDNF) and improves cognitive functions, including memory and learning. It is concluded that ginkgolide B, apparently, may find application in the future as a multi-targeted agent of complex therapy of AD.

Keywords:

Ginkgolide B
Alzheimer’s disease
beta-amyloid
microglia activation
BDNF
neurotransmitters
memory
learning

Authors:

Berezutsky M.A.

Razumovsky Saratov State Medical University

Durnova N.A.

Razumovsky Saratov State Medical University

Andronova T.A.

Razumovsky Saratov State Medical University

Received:

07.12.2023

Accepted:

16.12.2023

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