Experience of using the combined drug Mioreol in patients with Alzheimer’s disease and mixed dementia

Zakharov V.V.

Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0002-8447-3264

Koberskaya N.N.

Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0002-3110-4764

Experience of using the combined drug Mioreol in patients with Alzheimer’s disease and mixed dementia

Authors:

Zakharov V.V., Koberskaya N.N.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(9): 34‑43

DOI: 10.17116/jnevro202412409134

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To cite this article:

Zakharov VV, Koberskaya NN. Experience of using the combined drug Mioreol in patients with Alzheimer’s disease and mixed dementia. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(9):34‑43. (In Russ.)
https://doi.org/10.17116/jnevro202412409134

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)

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OBJECTIVE

The aim of the study was to evaluate the clinical efficacy, safety, and tolerability of a fixed-dose combination of donepezil and memantine (Mioreol) in patients with Alzheimer’s disease (AD) and AD with cerebrovascular pathology.

MATERIAL AND METHODS

497 patients with moderate to severe dementia, average age 75.4+6.81 years, received Mioreol (donepezil 10 mg+memantine 20 mg). Treatment efficacy was assessed using the MMSE, clock drawing, Sandoz Clinical Geriatric Scale, and Clinical Global Impressions after 3 months of therapy. All adverse events during treatment were recorded.

RESULTS

The transition to Mioreol was accompanied by a reliable improvement in cognitive functions, emotional-behavioral indicators and neuropsychiatric status in general.

CONCLUSIONS

Mioreol demonstrated clinical efficacy, safety and good tolerability in patients with AD and AD with cerebrovascular pathology with moderate to severe dementia syndrome.

Keywords:

Alzheimer’s disease

Alzheimer’s disease with cerebrovascular pathology

dementia

basic therapy for dementia

donepezil

memantine

Mioreol

Authors:

Zakharov V.V.

Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0002-8447-3264

Koberskaya N.N.

Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0002-3110-4764

Received:

27.08.2024

Accepted:

30.08.2024

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