The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.
Putyatin I.A.
Pirogov Russian National Research Medical University (Pirogovsky University)
Titova N.V.
Pirogov Russian National Research Medical University (Pirogovsky University);
Federal Center of Brain Research and Neurotechnologies
Neurochemical mechanisms of tremor in Parkinson’s disease
Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(11): 64‑72
Views: 577
Downloaded: 7
To cite this article:
Putyatin IA, Titova NV. Neurochemical mechanisms of tremor in Parkinson’s disease. S.S. Korsakov Journal of Neurology and Psychiatry.
2024;124(11):64‑72. (In Russ.)
https://doi.org/10.17116/jnevro202412411164
Tremor is one of the main motor symptoms of Parkinson’s disease, and its pathophysiology remains largely unknown. The clinical and pathomorphological heterogeneity of tremor and the not always response to therapy complicate the task of researchers and clinicians. This review discusses the specific degeneration of neurotransmitter systems driving the development of tremor, and the influence of neurotransmitters on specific anatomical entities according to current models explaining tremor. It is discusses how changes in neurotransmitter systems may influence the clinical diversity of tremor and differences in response to therapy. Data from clinical trials demonstrating the effect of the dopamine receptor agonist piribedil on tremor are presented.
Authors:
Putyatin I.A.
Pirogov Russian National Research Medical University (Pirogovsky University)
Titova N.V.
Pirogov Russian National Research Medical University (Pirogovsky University);
Federal Center of Brain Research and Neurotechnologies
Received:
16.08.2024
Accepted:
20.08.2024
List of references:
Close metadata
Email Confirmation
An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.
Email Confirmation
Log in to the site using your account in one of the services
We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.