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Mukhacheva D.A.

Mechnikov North-Western State Medical University

Raznatovsky K.I.

Mechnikov North-Western State Medical University

Sobolev A.V.

Mechnikov North-Western State Medical University

Treatment of atopic dermatitis considering assessment of neurotransmitters in blood

Authors:

Mukhacheva D.A., Raznatovsky K.I., Sobolev A.V.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2024;23(4): 368‑376

DOI: 10.17116/klinderma202423041368

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To cite this article:

Mukhacheva DA, Raznatovsky KI, Sobolev AV. Treatment of atopic dermatitis considering assessment of neurotransmitters in blood. Russian Journal of Clinical Dermatology and Venereology. 2024;23(4):368‑376. (In Russ.)
https://doi.org/10.17116/klinderma202423041368

Подписка 2025 (Russian Journal of Clinical Dermatology and Venereology)
 
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Atopic dermatitis (AD) is a disease manifested by intense itching and impaired barrier functions of the skin. Itching occurs when the nerve endings of the skin are activated by various inflammation mediators, neurotransmitters and neuropeptides.

OBJECTIVE

To systematize information about the role of neurotransmitters as markers of AD exacerbation, to assess their indices in blood in patients during therapy, to identify predictors of AD remission achievement by patient.

MATERIAL AND METHODS

Clinical laboratory examination of 168 patients with AD (42% male, 72.8% female) was carried out, among whom 127 persons with moderate to severe AD were identified (SCORAD >50). Predictors of patient’s achievement of mild AD have been identified and a model of logical regression has been developed.

RESULTS

A variable change of neurotransmitters in the blood serum has been revealed in patients in case of AD exacerbation. It has been established that the mean serotonin concentration was 107.8±50.1 ng/ml, median 102.4 (73.7; 134.3) ng/ml, reference values (RA) 36.0—82.0 ng/ml. A logistic regression model has been developed in the examination of 127 patients with moderate to severe AD (SCORAD >50). Serotonin has been found to be a significant (p=0.009) predictor for achieving the clinical effect of therapy along with SCORAD and patient age.

CONCLUSION

The obtained results can serve as diagnostic criteria for development of the most rational AD therapy considering the changes in the concentration of neurotransmitters in the blood serum.

Keywords:

atopic dermatitis
microbiome
biomarkers
neurotransmitters

Authors:

Mukhacheva D.A.

Mechnikov North-Western State Medical University

Raznatovsky K.I.

Mechnikov North-Western State Medical University

Sobolev A.V.

Mechnikov North-Western State Medical University

Received:

30.01.2024

Accepted:

02.07.2024

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