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Malashenkova I.K.

National Research Center «Kurchatov Institute»;
Federal Research and Clinical Center of Physical-Chemical Medicine

Krynskiy S.A.

National Research Center «Kurchatov Institute»;
Alekseev Psychiatric Clinical Hospital No. 1

Ogurtsov D.P.

National Research Center «Kurchatov Institute»;
Federal Research and Clinical Center of Physical-Chemical Medicine

Khailov N.A.

National Research Center «Kurchatov Institute»

Filippova E.A.

National Research Center «Kurchatov Institute»

Moskvina S.N.

National Research Center «Kurchatov Institute»

Ushakov V.L.

Alekseev Psychiatric Clinical Hospital No. 1;
National Research Nuclear University MEPhI;
Lomonosov Moscow State University

Orlov V.A.

National Research Center «Kurchatov Institute»

Andryushchenko A.V.

Alekseev Psychiatric Clinical Hospital No. 1;
Lomonosov Moscow State University

Osipova N.G.

Alexeev Psychiatric Hospital no. 1 of the Department of Health of Moscow

Syunyakov T.S.

Alekseev Psychiatric Clinical Hospital No. 1;
Republican Specialized Scientific-Practical Medical Center of Narcology;
Samara State Medical University

Savilov V.B.

Alexeev Psychiatric Hospital no. 1 of the Department of Health of Moscow

Karpenko O.A.

Alekseev Psychiatric Clinical Hospital No. 1

Kurmyshev M.V.

Alexeev Psychiatric Hospital no. 1 of the Department of Health of Moscow

Kostyuk G.P.

Alekseev Psychiatric Clinical Hospital No. 1

Didkovsky N.A.

Federal Research and Clinical Center of Physical-Chemical Medicine

Immunological and neuroanatomic markers of the clinical dynamics of MCI and pre-MCI

Authors:

Malashenkova I.K., Krynskiy S.A., Ogurtsov D.P., Khailov N.A., Filippova E.A., Moskvina S.N., Ushakov V.L., Orlov V.A., Andryushchenko A.V., Osipova N.G., Syunyakov T.S., Savilov V.B., Karpenko O.A., Kurmyshev M.V., Kostyuk G.P., Didkovsky N.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(8): 81‑91

DOI: 10.17116/jnevro202412408181

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Table of contents

IMMUNOLOGICAL AND NEUROANATOMIC MARKERS OF THE CLINICAL DYNAMICS OF MCI AND PRE-MCI
IMMUNOLOGICAL AND NEUROANATOMIC MARKERS OF THE CLINICAL DYNAMICS OF MCI AND PRE-MCI

To cite this article:

Malashenkova IK, Krynskiy SA, Ogurtsov DP, et al. . Immunological and neuroanatomic markers of the clinical dynamics of MCI and pre-MCI. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(8):81‑91. (In Russ.)
https://doi.org/10.17116/jnevro202412408181

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To study the relationship of the parameters of immunity and systemic inflammation with the structural magnetic resonance imaging (MRI) parameters in patients with mild cognitive impairment (MCI) and pre-MCI undergoing neurocognitive rehabilitation to search for candidate markers of its effectiveness.

MATERIAL AND METHODS

The main group included 49 patients, aged ≥60 years, with MCI and pre-MCI with memory impairment, who underwent a course of neurorehabilitation for 5 weeks. The control group included 19 volunteers of similar age with a total MoCA score of ≥25, who did not have cognitive impairment and immuno-inflammatory disorders. The parameters of cellular and humoral immunity and markers of inflammation were studied, and structural MRI was performed.

RESULTS

The content of activated natural killer cells (NK-cells) was increased in MCI and pre-MCI (0.63±0.12% vs. 0.22±0.07% in the control group, p=2.2·10–7). The level of immunoglobulin G (IgG) <12.5 g/l in patients with MCI and pre-MCI with the Montreal Cognitive Assessment Scale (MoCA) score <22 was associated with a decrease in the volume of the right nucleus accumbens (376±35 mm3 in patients with IgG <12.5 g/l (p=0.0013) and 480±44 mm3 at IgG <12.5 g/l, 480±44 mm3 in the control group), as well as with a decrease of the thickness and volume of a number of other cortical zones. A logistic regression model including the level of immunoglobulin G, NK cells, CD8+ NK cells and right amygdala volume was constructed to predict the number of MoCA scores 6 months after the course of rehabilitation (R2=0.57; p<1·10–5; standard error of estimate: 2.93).

CONCLUSION

As a result of this work, the perspectives of assessing the immunological parameters in combination with socio-demographic data and morphometric changes of the brain as potential prognostic markers of the dynamics of cognitive impairment in patients with MCI and pre-MCI after neurorehabilitation has been shown.

Keywords:

Alzheimer’s disease
amygdala
cell immunity
immunoglobulin G
magnetic resonance tomography
mild cognitive impairment
neurorehabilitation
NK cells

Authors:

Malashenkova I.K.

National Research Center «Kurchatov Institute»;
Federal Research and Clinical Center of Physical-Chemical Medicine

Krynskiy S.A.

National Research Center «Kurchatov Institute»;
Alekseev Psychiatric Clinical Hospital No. 1

Ogurtsov D.P.

National Research Center «Kurchatov Institute»;
Federal Research and Clinical Center of Physical-Chemical Medicine

Khailov N.A.

National Research Center «Kurchatov Institute»

Filippova E.A.

National Research Center «Kurchatov Institute»

Moskvina S.N.

National Research Center «Kurchatov Institute»

Ushakov V.L.

Alekseev Psychiatric Clinical Hospital No. 1;
National Research Nuclear University MEPhI;
Lomonosov Moscow State University

Orlov V.A.

National Research Center «Kurchatov Institute»

Andryushchenko A.V.

Alekseev Psychiatric Clinical Hospital No. 1;
Lomonosov Moscow State University

Osipova N.G.

Alexeev Psychiatric Hospital no. 1 of the Department of Health of Moscow

Syunyakov T.S.

Alekseev Psychiatric Clinical Hospital No. 1;
Republican Specialized Scientific-Practical Medical Center of Narcology;
Samara State Medical University

Savilov V.B.

Alexeev Psychiatric Hospital no. 1 of the Department of Health of Moscow

Karpenko O.A.

Alekseev Psychiatric Clinical Hospital No. 1

Kurmyshev M.V.

Alexeev Psychiatric Hospital no. 1 of the Department of Health of Moscow

Kostyuk G.P.

Alekseev Psychiatric Clinical Hospital No. 1

Didkovsky N.A.

Federal Research and Clinical Center of Physical-Chemical Medicine

Received:

15.03.2024

Accepted:

22.04.2024

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