The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Gorbachevskii A.V.

Tyumen State Medical University

Kicherova O.A.

Tyumen State Medical University

Reikhert L.I.

Tyumen State Medical University

The role of astrocytes, circadian rhythms and light pollution in the pathogenesis of Alzheimer’s disease

Authors:

Gorbachevskii A.V., Kicherova O.A., Reikhert L.I.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(6): 20‑25

DOI: 10.17116/jnevro202412406120

Read: 2059 times

Download PDF (RU)
Contact the author
Table of contents

THE ROLE OF ASTROCYTES, CIRCADIAN RHYTHMS AND LIGHT POLLUTION IN THE PATHOGENESIS OF ALZHEIMER’S DISEASE
THE ROLE OF ASTROCYTES, CIRCADIAN RHYTHMS AND LIGHT POLLUTION IN THE PATHOGENESIS OF ALZHEIMER’S DISEASE

To cite this article:

Gorbachevskii AV, Kicherova OA, Reikhert LI. The role of astrocytes, circadian rhythms and light pollution in the pathogenesis of Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(6):20‑25. (In Russ.)
https://doi.org/10.17116/jnevro202412406120

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Neurobiological pote­ntial of astragaloside IV and prospects for its use in the treatment of Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(2):7-12
Stress and sleep: Neurobiological aspe­cts and modern options of inso­mnia therapy. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5-2):14-21
Factors of depression acco­rding to acti­graphy in the fall season. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5-2):27-32
Inso­mnia in children. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5-2):46-51
The pote­ntial of neurofeedback control in treating inso­mnia and improving sleep quality (a systematic review). S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5-2):57-63
Cyto­kine status of patients with Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):5-12
Curcumin-induced increased reti­nal fluorescence as a new method in the early diagnosis of Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):19-25
Differential diagnosis of Alzheimer’s disease and vascular cognitive diso­rders. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):26-35
A comprehensive study of Alzheimer’s disease biomarkers in plasma and cere­brospinal fluid. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):43-53
Prospects for treating Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):54-60
Abstract:

Currently, more and more importance is being attached to the interaction of brain neurons with astrocytes in order to study the pathogenesis, and in the future, to develop methods for the prevention, early diagnosis and treatment of neurodegenerative diseases of the brain. In this review article, the authors attempt to demonstrate the role of astrocytes, disturbances in circadian rhythms, sleep-wake patterns, and light pollution in the development of Alzheimer’s disease. Based on the analysis of literature data, possible mechanisms of synchronization and desynchronization of these processes are presented.

Keywords:

astrocyte
circadian rhythm
sleep
light pollution
Alzheimer’s disease

Authors:

Gorbachevskii A.V.

Tyumen State Medical University

Kicherova O.A.

Tyumen State Medical University

Reikhert L.I.

Tyumen State Medical University

Received:

07.03.2024

Accepted:

15.03.2024

Close metadata

References:

  1. Lenhossék M. Der feinere Bau des Nervensystems im Lichte neuester Forschung (2nd ed.). Berlin: Fischer’s Medicinische Buchhandlung H. Kornfield; 1895.
  2. Verkhratsky A, Nedergaard M. Physiology of Astroglia. Physiol Rev. 2018;98(1):239-389.  https://doi.org/10.1152/physrev.00042.2016
  3. Noriega-Prieto JA, Araque A. Sensing and Regulating Synaptic Activity by Astrocytes at Tripartite Synapse. Neurochem Res. 2021;46(10):2580-2585. https://doi.org/10.1007/s11064-021-03317-x
  4. Andersen JV, Markussen KH, Jakobsen E, et al. Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration. Neuropharmacology. 2021;196:108719. https://doi.org/10.1016/j.neuropharm.2021.108719
  5. Scofield MD. Exploring the Role of Astroglial Glutamate Release and Association With Synapses in Neuronal Function and Behavior. Biol Psychiatry. 2018;84(11):778-786.  https://doi.org/10.1016/j.biopsych.2017.10.029
  6. Postnov D, Semyachkina-Glushkovskaya O, Litvinenko E, et al. Mechanisms of Activation of Brain’s Drainage during Sleep: The Nightlife of Astrocytes. Cells. 2023;12(22):2667. https://doi.org/10.3390/cells12222667
  7. Rowsthorn E, Pham W, Nazem-Zadeh MR, et al. Imaging the neurovascular unit in health and neurodegeneration: a scoping review of interdependencies between MRI measures. Fluids Barriers CNS. 2023;20(1):97.  https://doi.org/10.1186/s12987-023-00499-0
  8. Hastings MH, Brancaccio M, Gonzalez-Aponte MF, et al. Circadian Rhythms and Astrocytes: The Good, the Bad, and the Ugly. Annu Rev Neurosci. 2023;46:123-143.  https://doi.org/10.1146/annurev-neuro-100322-112249
  9. Patton AP, Morris EL, McManus D, et al. Astrocytic control of extracellular GABA drives circadian timekeeping in the suprachiasmatic nucleus. Proc Natl Acad Sci USA. 2023;120(21):e2301330120. https://doi.org/10.1073/pnas.2301330120
  10. Brancaccio M, Patton AP, Chesham JE, et al. Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling. Neuron. 2017;93(6):1420-1435.e5.  https://doi.org/10.1016/j.neuron.2017.02.030
  11. Zeman M, Okuliarova M, Rumanova VS. Disturbances of Hormonal Circadian Rhythms by Light Pollution. Int J Mol Sci. 2023;24(8):7255. https://doi.org/10.3390/ijms24087255
  12. Xie L, Kang H, Xu Qt, et al. Sleep drives metabolite clearance from the adult brain. Science. 2013;342(6156):373-377.  https://doi.org/10.1126/science.1241224
  13. Iliff JJ, Wang M, Kang H, et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci Transl Med. 2012;4(147):147ra111. https://doi.org/10.1126/scitranslmed.3003748
  14. Brockett AT, Kane GA, Monari PK, et al. Evidence supporting a role for astrocytes in the regulation of cognitive flexibility and neuronal oscillations through the Ca2+ binding protein S100β. PLoS One. 2018;13(4):e0195726. https://doi.org/10.1371/journal.pone.0195726
  15. Bojarskaite L, Bjørnstad DM, Pettersen KH, et al. Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep. Nat Commun. 2020;11(1):3240. https://doi.org/10.1038/s41467-020-17062-2
  16. Ingiosi AM, Hayworth CR, Harvey DO, et al. A Role for Astroglial Calcium in Mammalian Sleep and Sleep Regulation. Curr Biol. 2020;30(22):4373-4383.e7.  https://doi.org/10.1016/j.cub.2020.08.052
  17. Bellot-Saez A, Cohen G, van Schaik A, et al. Astrocytic modulation of cortical oscillations. Sci Rep. 2018;8(1):11565. https://doi.org/10.1038/s41598-018-30003-w
  18. Fultz NE, Bonmassar G, Setsompop K, et al. Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep. Science. 2019;366(6465):628-631.  https://doi.org/10.1126/science.aax5440
  19. Barisano G, Sheikh-Bahaei N, Law M, et al. Body mass index, time of day and genetics affect perivascular spaces in the white matter. J Cereb Blood Flow Metab. 2021;41(7):1563-1578. https://doi.org/10.1177/0271678X20972856
  20. Gędek A, Koziorowski D, Szlufik S. Assessment of factors influencing glymphatic activity and implications for clinical medicine. Front Neurol. 2023;14:1232304. https://doi.org/10.3389/fneur.2023.1232304
  21. Semyachkina-Glushkovskaya OV, Karavaev AS, Prokhorov MD, et al. EEG biomarkers of activation of the lymphatic drainage system of the brain during sleep and opening of the blood-brain barrier. Comput Struct Biotechnol J. 2022;21:758-768.  https://doi.org/10.1016/j.csbj.2022.12.019
  22. Bará S, Falchi F. Artificial light at night: a global disruptor of the night-time environment. Philos Trans R Soc Lond B Biol Sci. 2023;378(1892):20220352. https://doi.org/10.1098/rstb.2022.0352
  23. Wahl S, Engelhardt M, Schaupp P, et al. The inner clock-Blue light sets the human rhythm. J Biophotonics. 2019;12(12):e201900102. https://doi.org/10.1002/jbio.201900102
  24. Karska J, Kowalski S, Gładka A, et al. Artificial light and neurodegeneration: does light pollution impact the development of Alzheimer’s disease? Geroscience. 2024;46(1):87-97.  https://doi.org/10.1007/s11357-023-00932-0
  25. Lee YF, Gerashchenko D, Timofeev I, et al. Slow Wave Sleep Is a Promising Intervention Target for Alzheimer’s Disease. Front Neurosci. 2020;14:705.  https://doi.org/10.3389/fnins.2020.00705
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.