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Skripchenko N.V.

Pediatric Research and Clinical Center for Infectious Diseases;
Saint Petersburg State Pediatric Medical University

Alekseeva L.A.

Pediatric Research and Clinical Center for Infectious Diseases

Zheleznikova G.F.

Pediatric Research and Clinical Center for Infectious Diseases

Skripchenko E.Yu.

Pediatric Research and Clinical Center for Infectious Diseases;
Saint Petersburg State Pediatric Medical University

Bessonova T.V.

Pediatric Research and Clinical Center for Infectious Diseases

Zhirkov A.A.

Pediatric Research and Clinical Center for Infectious Diseases

Factors of the hemostasis system as biomarkers of severe course of acute viral infections

Authors:

Skripchenko N.V., Alekseeva L.A., Zheleznikova G.F., Skripchenko E.Yu., Bessonova T.V., Zhirkov A.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(3): 63‑74

DOI: 10.17116/jnevro202412403163

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To cite this article:

Skripchenko NV, Alekseeva LA, Zheleznikova GF, Skripchenko EYu, Bessonova TV, Zhirkov AA. Factors of the hemostasis system as biomarkers of severe course of acute viral infections. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(3):63‑74. (In Russ.)
https://doi.org/10.17116/jnevro202412403163

Подписка 2025 (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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The authors give literature review of hemostasis and immune system factors intraction as main biomarkers of a severe cause of viral infectious diseases. Pro-inflamatory cytokines as the main markers of inflammation, can serve both as biomarkers of the clinical severity of the infectious process and reflect the state of the hemostatic and fibrinolytic systems, since components of these systems are present in various structures of the central nervous system and affect the development of neurons and synaptic plasticity. An inverse correlation has been proven between the concentration of D-dimer and the oxygenation index, and the development of DIC is not associated with the presence of respiratory failure in patients with influenza type A, while the ferritin concentration directly reflects the severity of the disease. One of the markers of endothelial damage may be soluble thrombomodulin, which, however, is rarely used in routine clinical practice. Cytoflavin is a highly effective pathogenetic drug that affects various parts of the hemostasis system, has anti-ischemic, antioxidant, antihypoxic, immunocorrective effect, which is indicated for any generalized infectious disease since its debut.

Keywords:

immune system
hemostasis system
viral infections
Cytoflavin

Authors:

Skripchenko N.V.

Pediatric Research and Clinical Center for Infectious Diseases;
Saint Petersburg State Pediatric Medical University

Alekseeva L.A.

Pediatric Research and Clinical Center for Infectious Diseases

Zheleznikova G.F.

Pediatric Research and Clinical Center for Infectious Diseases

Skripchenko E.Yu.

Pediatric Research and Clinical Center for Infectious Diseases;
Saint Petersburg State Pediatric Medical University

Bessonova T.V.

Pediatric Research and Clinical Center for Infectious Diseases

Zhirkov A.A.

Pediatric Research and Clinical Center for Infectious Diseases

Received:

26.01.2024

Accepted:

01.02.2024

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