Psoriasis in pregnant women

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Psoriasis is a chronic skin disease. There is no clear opinion on psoriasis course in pregnant women in literature. Many women have stabilization and improvement of state, but not all. Remission and improvement of psoriasis course are possible due to pregnant women endocrine profile. Chorionic gonadotropin, progesterone, estradiol and placental lactogen modify the mother’s immune response from Th1 inflammatory cytokines pattern to Th2 pattern. The influence of Th17 is also decreasing. Meanwhile, psoriasis exacerbation can occur at any period of pregnancy. Its main causes are the progression of metabolic syndrome and insulin resistance, psycho-emotional stress, gastrointestinal tract activity disorder, toxicoses and gestoses. Treatment options for pregnant women are limited due to unethical issues of conducting clinical trials. It’s safe to use topical glucocorticoids, narrow-band UVB equal 311 nm, moisturizing and peeling products based on 30—50% of urea, zinc preparations (0.2% zinc pyrithione). Cyclosporine and systemic glucocorticoids are recommended to use as a systemic therapy in case of severe course. There are studies on the safety of applying some types of biological drugs in pregnant women with sufficient evidence base.

Keywords:

psoriasis

pregnancy

peeling products

treatment

immune system

Authors:

Albanova V.I.

Vladimirsky Moscow Regional Research Clinical Institute

ORCID: 0000-0001-8688-7578

Petrova S.Yu.

Mechnikov Research Institute of Vaccines and Sera;
Retinoids JSC

ORCID: 0000-0003-3034-0148

Received:

08.07.2024

Accepted:

22.07.2024

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