Neuroprotective effect of cytoflavin in the treatment of premature newborns with hypoxic-ischemic encephalopathy

Salikhova K.Sh.; Agzamhodjayeva B.U.; Abdurahmanova F.R.; Ishniyazova N.D.; Salikhova S.M.

doi:https://doi.org/10.17116/jnevro202412409168

Salikhova K.Sh.

Republican Specialized Scientific Practice Medical Center of Pediatrics

ORCID: 0000-0002-0548-2673

Agzamhodjayeva B.U.

Republican Specialized Scientific Practice Medical Center of Pediatrics

ORCID: 0009-0001-4122-9966

Abdurahmanova F.R.

Republican Specialized Scientific Practice Medical Center of Pediatrics

ORCID: 0009-0007-6571-5903

Ishniyazova N.D.

Tashkent Pediatric Medical Institute

ORCID: 0000-0001-9011-1609

Salikhova S.M.

Tashkent Pediatric Medical Institute

ORCID: 0000-0002-0548-2673

Neuroprotective effect of cytoflavin in the treatment of premature newborns with hypoxic-ischemic encephalopathy

Authors:

Salikhova K.Sh., Agzamhodjayeva B.U., Abdurahmanova F.R., Ishniyazova N.D., Salikhova S.M.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(9): 68‑72

DOI: 10.17116/jnevro202412409168

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To cite this article:

Salikhova KSh, Agzamhodjayeva BU, Abdurahmanova FR, Ishniyazova ND, Salikhova SM. Neuroprotective effect of cytoflavin in the treatment of premature newborns with hypoxic-ischemic encephalopathy. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(9):68‑72. (In Russ.)
https://doi.org/10.17116/jnevro202412409168

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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OBJECTIVE

Evaluation of the effectiveness of Cytoflavin as a neuroprotective therapy for neurological complications in premature newborns with hypoxic-ischemic encephalopathy.

MATERIAL AND METHODS

56 premature newborns with low body weight were examined. Newborn children, depending on the therapy, were divided into 2 groups: Group I — 32 premature newborns with hypoxic-ischemic encephalopathy; received basic therapy and Cytoflavin; Group II — 24 premature newborns with hypoxic-ischemic encephalopathy; received only basic therapy. Moreover, the state of neurospecific enolase (NSE) and blood lactate were studied.

RESULTS

Patients of the first group who received cytoflavin, on days 5—6 after treatment there was a decrease in the severity of cerebral ischemia. Also, decreased levels of NSE and blood lactate.

CONCLUSION

The revealed neuroprotective effect of cytoflavin in the treatment of premature newborns with hypoxic-ischemic encephalopathy, good tolerability of the drug and its compatibility with other drugs used in the standard treatment of perinatal lesions of the nervous system, which makes it possible to recommend Cytoflavin for the treatment of neurometabolic disorders in children in the first months of life in complex therapy perinatal lesions of the nervous system of premature newborns.

Keywords:

premature newborns

hypoxic encephalopathy

Cytoflavin

lactate

neurospecific enolase

Authors:

Salikhova K.Sh.

Republican Specialized Scientific Practice Medical Center of Pediatrics

ORCID: 0000-0002-0548-2673

Agzamhodjayeva B.U.

Republican Specialized Scientific Practice Medical Center of Pediatrics

ORCID: 0009-0001-4122-9966

Abdurahmanova F.R.

Republican Specialized Scientific Practice Medical Center of Pediatrics

ORCID: 0009-0007-6571-5903

Ishniyazova N.D.

Tashkent Pediatric Medical Institute

ORCID: 0000-0001-9011-1609

Salikhova S.M.

Tashkent Pediatric Medical Institute

ORCID: 0000-0002-0548-2673

Received:

04.07.2024

Accepted:

11.07.2024

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References:

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