Neuroprotective effect of cytoflavin in the treatment of premature newborns with hypoxic-ischemic encephalopathy

Salikhova K.Sh.

Republican Specialized Scientific Practice Medical Center of Pediatrics

ORCID: 0000-0002-0548-2673

Agzamhodjayeva B.U.

Republican Specialized Scientific Practice Medical Center of Pediatrics

ORCID: 0009-0001-4122-9966

Abdurahmanova F.R.

Republican Specialized Scientific Practice Medical Center of Pediatrics

ORCID: 0009-0007-6571-5903

Ishniyazova N.D.

Tashkent Pediatric Medical Institute

ORCID: 0000-0001-9011-1609

Salikhova S.M.

Tashkent Pediatric Medical Institute

ORCID: 0000-0002-0548-2673

Neuroprotective effect of cytoflavin in the treatment of premature newborns with hypoxic-ischemic encephalopathy

Authors:

Salikhova K.Sh., Agzamhodjayeva B.U., Abdurahmanova F.R., Ishniyazova N.D., Salikhova S.M.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(9): 68‑72

DOI: 10.17116/jnevro202412409168

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To cite this article:

Salikhova KSh, Agzamhodjayeva BU, Abdurahmanova FR, Ishniyazova ND, Salikhova SM. Neuroprotective effect of cytoflavin in the treatment of premature newborns with hypoxic-ischemic encephalopathy. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(9):68‑72. (In Russ.)
https://doi.org/10.17116/jnevro202412409168

Подписка 2025 (S.S. Korsakov Journal of Neurology and Psychiatry)

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OBJECTIVE

Evaluation of the effectiveness of Cytoflavin as a neuroprotective therapy for neurological complications in premature newborns with hypoxic-ischemic encephalopathy.

MATERIAL AND METHODS

56 premature newborns with low body weight were examined. Newborn children, depending on the therapy, were divided into 2 groups: Group I — 32 premature newborns with hypoxic-ischemic encephalopathy; received basic therapy and Cytoflavin; Group II — 24 premature newborns with hypoxic-ischemic encephalopathy; received only basic therapy. Moreover, the state of neurospecific enolase (NSE) and blood lactate were studied.

RESULTS

Patients of the first group who received cytoflavin, on days 5—6 after treatment there was a decrease in the severity of cerebral ischemia. Also, decreased levels of NSE and blood lactate.

CONCLUSION

The revealed neuroprotective effect of cytoflavin in the treatment of premature newborns with hypoxic-ischemic encephalopathy, good tolerability of the drug and its compatibility with other drugs used in the standard treatment of perinatal lesions of the nervous system, which makes it possible to recommend Cytoflavin for the treatment of neurometabolic disorders in children in the first months of life in complex therapy perinatal lesions of the nervous system of premature newborns.

Keywords:

premature newborns

hypoxic encephalopathy

Cytoflavin

lactate

neurospecific enolase

Authors:

Salikhova K.Sh.

Republican Specialized Scientific Practice Medical Center of Pediatrics

ORCID: 0000-0002-0548-2673

Agzamhodjayeva B.U.

Republican Specialized Scientific Practice Medical Center of Pediatrics

ORCID: 0009-0001-4122-9966

Abdurahmanova F.R.

Republican Specialized Scientific Practice Medical Center of Pediatrics

ORCID: 0009-0007-6571-5903

Ishniyazova N.D.

Tashkent Pediatric Medical Institute

ORCID: 0000-0001-9011-1609

Salikhova S.M.

Tashkent Pediatric Medical Institute

ORCID: 0000-0002-0548-2673

Received:

04.07.2024

Accepted:

11.07.2024

List of references:

Amirova VR, Valiulina AYa, Zalalova AA, Rybalko OV. The state of health of children in the first year of life born prematurely. Medical Bulletin of Bashkortostan. 2019;14(79):69-77. (In Russ.).
Andreev AV, Kharlamova NV, Shilova NA, Pesenkina AA. Risk factors for the development of intraventricular hemorrhages in very premature newborns with respiratory distress syndrome. Russian Bulletin of Perinatology and Pediatrics. 2021;66(5):49-55. (In Russ.).
Anuriev AM, Gorbachev VI. Hypoxic-ischemic brain damage in premature newborns. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(8 vyp. 2):63-69. (In Russ.). https://doi.org/10.17116/jnevro201911908263
Bazarny VV, Volkhina SA, Mikhailova EYu. Neurotrophic factors in the diagnosis of hypoxic-ischemic damage to the central nervous system in children. Bulletin of the Ural Medical Academic Science. 2015;4(55):54-56. (In Russ.).
Bon EI, Maksimovich NE. The role of mitochondria in cell energy and its characterizing molecular markers. Orenburg Medical Bulletin. 2019;7(25):47-52. (In Russ.).
Zavadenko NN, Davydova LA. Prematurity and low birth weight as risk factors for neuropsychological development disorders in children. Russian Bulletin of Perinatology and Pediatrics. 2018;63(4):43-51. (In Russ.).
Zadvornov AA, Golomidov AV, Grigoriev EV. Biomarkers of perinatal damage to the central nervous system. Neonatology. 2017;1:47-57. (In Russ.).
Koval’chuk VV, Zueva IB, Nesterin KV, et al. The use of citoflavin in neonatology and pediatrics as a factor improving therapeutic efficacy in patients with central nervous system lesions of various etiology. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(5-2):46-50. (In Russ.). https://doi.org/10.17116/jnevro20181185246
Kokhanov AV, Voronkova MYu, Bisalieva RA, et al. Neurospecific proteins with extreme physicochemical characteristics and their significance in assessing complications of neurotrauma [Electronic resource]. Modern Problems of Science and Education. 2015;5:23-29. (In Russ.).
Morozova AYu, Milyutina YuP, Arutyunyan AV, Evsyukova II. The content of neuron-specific enolase and neurotrophic growth factor in the umbilical cord blood of full-term newborns with intrauterine growth retardation. Journal of Obstetrics and Women’s Diseases. 2019;68(6):29-36. (In Russ.).
Ovchinnikova TA, Parkheta KA, Zubkova AYu, et al. The influence of gestational age and body weight on the degree of intraventricular hemorrhage in premature newborns. Bulletin of Modern Research. 2017;7-1(10):22-25. (In Russ.).
Skripchenko NV, Shirokova AS. Neuron-specific enolase and S100 protein are biomarkers of brain damage. State of the issue and clinical application. Neurosurgery and Neurology of Childhood. 2016;4(50):16-25. (In Russ.).
Cizmeci MN. Periventricular Hemorrhagic Infarction in Very Preterm Infants: Characteristic Sonographic Findings and Association with Neurodevelopmental Outcome at Age 2 Years. J Pediatr Elsevier Inc. 2020;217:79-85.
Dinomais M, Marret S, Vuillerot C. Brain plasticity and early rehabilitative care for children after neonatal arterial cerebral infarction. Arch Pediatr. 2017;24(9):9S61-9S68. https://doi.org/10.1016/S0929-693X(17)30333-0
Yilmaz A, Cebi MN, Yilmaz G, et al. Long-term neurodevelopmental effects of exclusively high cord lactate levels in term newborn. J Maternal-Fetal Neonat Med. 2023;36(2):2284115. https://doi.org/10.1080/14767058.2023.2284115
Volpe JJ. Neyrology of the Newborn. 5th ed. Philadelphia: Elsevier. 2008.

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