Structural features of the brain in individuals with youth depression at a clinical risk for psychosis

Dudina A.N.

Mental Health Research Center

ORCID: 0000-0002-3997-1782

Tomyshev A.S.

Mental Health Research Center

ORCID: 0000-0001-6688-4329

Omelchenko M.A.

Mental Health Research Centre

SPIN RSCI: 1643-9032
Scopus AuthorID: 35773602800
ResearcherID: K-6508-2016
ORCID: 0000-0001-8343-168X

Kaleda V.G.

Mental Health Research Centre

SPIN RSCI: 9035-3290
Scopus AuthorID: 56765570100
ResearcherID: K-5466-2013
ORCID: 0000-0002-1209-1443

Lebedeva I.S.

Mental Health Research Center

ORCID: 0000-0002-0649-6663

Structural features of the brain in individuals with youth depression at a clinical risk for psychosis

Authors:

Dudina A.N., Tomyshev A.S., Omelchenko M.A., Kaleda V.G., Lebedeva I.S.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(6): 94‑99

DOI: 10.17116/jnevro202312306194

Downloaded: 25

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To cite this article:

Dudina AN, Tomyshev AS, Omelchenko MA, Kaleda VG, Lebedeva IS. Structural features of the brain in individuals with youth depression at a clinical risk for psychosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(6):94‑99. (In Russ.)
https://doi.org/10.17116/jnevro202312306194

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)

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OBJECTIVE

To establish the structural features of the brain (cortical and subcortical) in depressive patients at clinical risk for psychosis.

MATERIAL AND METHODS

Nineteen right-handed male patients with youth depression, who were assessed for high risk of psychotic manifestation, and 20 healthy controls underwent MRI and clinical examination. T1-weighted images were processed in FreeSurfer 7.1.1. For each subject average values for the cortex thickness and area, volumes of subcortical structures, and separately volumes of the amygdala nuclei were obtained. Intergroup comparisons and correlations with clinical scales (SOPS, HDRS) were calculated.

RESULTS

Patients showed decreased gray matter thickness in the left (p=0.002) and right (p=0.003) postcentral gyri and increased thickness in the right posterior cingulate cortex (p=0.003) and rostral anterior cingulate cortex (p=0.001).

CONCLUSION

These findings may reflect cortical changes at early stages of the psychotic process, including the gray matter loss in some areas and the opposite phenomena in others (it cannot be ruled out that the latter may be the result of altered ontogenesis and/or certain compensatory changes).

Keywords:

clinical risk for psychosis

schizophrenia

youth depression

MRI

cortical thickness

cingulate cortex

Authors:

Dudina A.N.

Mental Health Research Center

ORCID: 0000-0002-3997-1782

Tomyshev A.S.

Mental Health Research Center

ORCID: 0000-0001-6688-4329

Omelchenko M.A.

Mental Health Research Centre

SPIN RSCI: 1643-9032
Scopus AuthorID: 35773602800
ResearcherID: K-6508-2016
ORCID: 0000-0001-8343-168X

Kaleda V.G.

Mental Health Research Centre

SPIN RSCI: 9035-3290
Scopus AuthorID: 56765570100
ResearcherID: K-5466-2013
ORCID: 0000-0002-1209-1443

Lebedeva I.S.

Mental Health Research Center

ORCID: 0000-0002-0649-6663

Received:

14.11.2022

Accepted:

14.02.2023

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