The influence of age and gender on the characteristics of cognitive impairment in patients with cardiovascular risks

Vorobeva O.V.; Pilipovich A.A.; Nikulina K.V.

doi:https://doi.org/10.17116/jnevro202212206185

Vorobeva O.V.

Chuvash state university named after I.N. Ulyanov

SPIN RSCI: 5084-1379
ORCID: 0000-0003-3259-3691

Pilipovich A.A.

Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0001-7416-9050

Nikulina K.V.

Sechenov First Moscow State Medical University (Sechenov University)

The influence of age and gender on the characteristics of cognitive impairment in patients with cardiovascular risks

Authors:

Vorobeva O.V., Pilipovich A.A., Nikulina K.V.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(6): 85‑92

DOI: 10.17116/jnevro202212206185

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To cite this article:

Vorobeva OV, Pilipovich AA, Nikulina KV. The influence of age and gender on the characteristics of cognitive impairment in patients with cardiovascular risks. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(6):85‑92. (In Russ.)
https://doi.org/10.17116/jnevro202212206185

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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OBJECTIVE

Assessment of the features of cognitive impairment in patients with vascular risk factors, depending on age and gender.

MATERIAL AND METHODS

The observational cross-sectional study included data from 1.651 patients aged 45 to 84 years with vascular risk factors from various regions of the Russian Federation. The presence and nature of cognitive impairment (CI) were detected using the MOCA test, taking into account the total MOCA score and MOCA indexes evaluating violations of individual cognitive functions (memory, attention, speech, executive and visual-constructive functions, orientation).

RESULTS

CI was detected in 89.2% of the surveyed (the total score of the MOCA <26). In middle-aged patients, 45—49 years old, executive functions and attention suffered more. The negative dynamics of CI significantly worsened in the age range of 70—75 years, statistically significantly increased every subsequent five years and was manifested by deterioration both in the mnestic sphere and in other cognitive domains. Statistically significant differences in the indicators of the total MOCA score in women and men were revealed at the age of 80—84 years (16.1 vs. 13.8 points, respectively, p=0.0279). By the age of 80—84, women had higher indicators of attention (p=0.025) and orientation (p=0.028) than men of the same age.

CONCLUSION

The data obtained make it possible to identify patients, regardless of gender, under the age of 70 as an important target group for the treatment and more aggressive prevention of CI.

Keywords:

age

gender differences

MoSA indexes

mild cognitive impairment

vascular risk factors

Authors:

Vorobeva O.V.

Chuvash state university named after I.N. Ulyanov

SPIN RSCI: 5084-1379
ORCID: 0000-0003-3259-3691

Pilipovich A.A.

Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0001-7416-9050

Nikulina K.V.

Sechenov First Moscow State Medical University (Sechenov University)

Received:

15.02.2022

Accepted:

21.02.2022

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