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Strumentova E.S.

I.I. Mechnikov North-Western State Medical University

Lobzin V.Yu.

I.I. Mechnikov North-Western State Medical University;
S.M. Kirov Military Medical Academy;
Saint-Petersburg State University

Maltsev D.S.

S.M. Kirov Military Medical Academy

Burnasheva M.A.

S.M. Kirov Military Medical Academy

Sergeeva T.V.

Saint-Petersburg State University;
City Hospital of St. Elizabeth the Great Martyr;
Saint-Petersburg State Paediatric Medical University

Buryak A.B.

Saint-Petersburg State University;
City Hospital of St. Elizabeth the Great Martyr

Curcumin-induced increased retinal fluorescence as a new method in the early diagnosis of Alzheimer’s disease

Authors:

Strumentova E.S., Lobzin V.Yu., Maltsev D.S., Burnasheva M.A., Sergeeva T.V., Buryak A.B.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(4‑2): 19‑25

DOI: 10.17116/jnevro202512504219

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Table of contents

CURCUMIN-INDUCED INCREASED RETINAL FLUORESCENCE AS A NEW METHOD IN THE EARLY DIAGNOSIS OF ALZHEIMER’S DISEASE
CURCUMIN-INDUCED INCREASED RETINAL FLUORESCENCE AS A NEW METHOD IN THE EARLY DIAGNOSIS OF ALZHEIMER’S DISEASE

To cite this article:

Strumentova ES, Lobzin VYu, Maltsev DS, Burnasheva MA, Sergeeva TV, Buryak AB. Curcumin-induced increased retinal fluorescence as a new method in the early diagnosis of Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(4‑2):19‑25. (In Russ.)
https://doi.org/10.17116/jnevro202512504219

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
 
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OBJECTIVE

To search for an effective method for early diagnosis of Alzheimer’s disease (AD) and mild cognitive impairment (MCI) of amnestic type using scanning laser ophthalmoscopy as a safe and widely available examination method.

MATERIAL AND METHODS

The study included 45 patients: 20 with AD, 10 with MCI, and 15 healthy control subjects. The patients were examined to visualize amyloid deposition in the retina using a solid lipid food curcumin ligand and a modified scanning laser ophthalmoscope, with a total of 63 observations since not all subjects were eligible for assessment of the retinas of both eyes. All patients underwent a neurological and ophthalmological examination, neuropsychological testing (MMSE, FCSRT, Clock Drawing test), brain MRI for visual assessment of atrophic changes (using global cortical atrophy scales, GCA and the medial temporal lobe atrophy, MTA), as well as confocal scanning laser ophthalmoscopy at two timepoints before and during curcumin administration. A semi-automated calculation of the area increase multiplicity (S) and the number (N) of particles with peak brightness (PPB) was performed.

RESULTS

In patients with AD, the following findings were obtained after taking curcumin: NPPB 167% [129; 258] (p=0.1) and SPPB 198% [148; 230] (p=0.007); MCI: NPPB 123% [114; 157] (p=0.15) and SPPB 129% [110; 140] (p=0.08).

CONCLUSION

The results indicate an increased deposition of beta-amyloid protein in the retina in patients with AD and expand the possibilities of its early diagnosis.

Keywords:

Alzheimer’s disease
mild cognitive impairment
beta-amyloid protein
eye
retina
curcumin
scanning laser ophthalmoscopy

Authors:

Strumentova E.S.

I.I. Mechnikov North-Western State Medical University

Lobzin V.Yu.

I.I. Mechnikov North-Western State Medical University;
S.M. Kirov Military Medical Academy;
Saint-Petersburg State University

Maltsev D.S.

S.M. Kirov Military Medical Academy

Burnasheva M.A.

S.M. Kirov Military Medical Academy

Sergeeva T.V.

Saint-Petersburg State University;
City Hospital of St. Elizabeth the Great Martyr;
Saint-Petersburg State Paediatric Medical University

Buryak A.B.

Saint-Petersburg State University;
City Hospital of St. Elizabeth the Great Martyr

Received:

28.01.2025

Accepted:

31.01.2025

List of references:

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  2. Tkacheva ON. Clinical recommendations: cognitive disorders in the elderly and senile. O.N. Tkacheva, N.N. Yakhno, N.G. Neznanov, et al. M.: Ministry of Health of the Russian Federation. 2020. (In Russ.).
  3. Frolova EV, Emelin AY, Lobzin VY. Cognitive impairment in old age: a guide for physicians. Moscow: LLC «GEOTAR-Media». 2023. (In Russ.).
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  6. Bogolepova AN, Makhnovich EV, Kovalenko EA, et al. Potential biomarkers of early diagnosis of Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(9):7-14. (In Russ.). https://doi.org/10.17116/jnevro20221220917
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  11. den Haan J, Morrema THJ, Rozemuller AJ, et al. Different curcumin forms selectively bind fibrillar amyloid beta in post mortem Alzheimer’s disease brains: Implications for in-vivo diagnostics. Acta Neuropathol Commun. 2018;6(1):75.  https://doi.org/10.1186/s40478-018-0577-2
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