Stress, asthenia and cognitive disorders

Vasenina E.E.; Gankina O.A.; Levin O.S.

doi:https://doi.org/10.17116/jnevro202212205123

Close metadata

Recommended articles:

Asthenia in the acute period of ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(3-2):5-10

Comparative study of cognitive impairment in subgroups of bipolar affective disorder types I and II, occurring with and without psychotic symptoms. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(3):7-11

Cognitive impairment in asthenic disorders. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(3):27-32

Relationship between stroke-associated pneumonia and long-term outcomes of ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(3):57-61

Combined treatment of patients with acute muscular tonic syndrome with dorsopathy. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(3):70-77

Modern approaches to diagnosis and treatment of postinfectious asthenic syndrome in children. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4):42-52

Characteristics, treatment features and in-hospital mortality of patients with myocardial infarction over 75 years old in Russia according to the REGION-IM registry. Russian Cardiology Bulletin. 2025;(1):22-38

Pharmacological treatment and prevention of ischemia-reperfusion syndrome in percutaneous coronary intervention. Russian Journal of Cardiology and Cardiovascular Surgery. 2025;(2):191-200

Influence of griseofulvin on intestinal microbiota in the treatment of microsporia in rural children. Russian Journal of Clinical Dermatology and Venereology. 2025;(2):185-190

Study of the levocarnitine efficacy for the treatment of moderate cognitive impairment in patients with hypertension. Russian Journal of Preventive Medicine. 2025;(4):45-50

Abstract:

Asthenia is a clinical syndrome that nearly any somatic and neurological pathologies can manifest with. Being is essence a defense mechanism that signals the depletion of energy resources, asthenia can become a pathological, extremely disabling condition, and even transform into a nosology of its own — the chronic fatigue syndrome, an immune-mediated disease. Besides, asthenia is often combined with affective and cognitive disorders, which facilitates difficulties in the establishing of the primary diagnosis. In this article we examine the complicated weave of asthenia, chronic fatigue syndrome, cognitive, and affective disorders.

Keywords:

asthenia

chronic fatigue syndrome

cognitive impairment

affective disorders

treatment

Authors:

Vasenina E.E.

Russian Medical Academy of Continuous Professional Education

Gankina O.A.

Russian Medical Academy of Continuous Professional Education

Levin O.S.

Russian Medical Academy of Continuous Professional Education

SPIN RSCI: 5342-1373
Scopus AuthorID: 57147160800
ORCID: 0000-0003-3872-5923

Received:

01.04.2022

Accepted:

05.04.2022

Close metadata

References:

Bateman L, Bested AC, Bonilla HF, et al. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Essentials of Diagnosis and Management. Mayo Clin Proc. 2021;96(11):2861-2878. https://doi.org/10.1016/j.mayocp.2021.07.004
Gandasegui IM, Laka LA, Gargiulo PÁ, et al. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Neurological Entity? Medicina (Kaunas). 2021;57(10):1030. https://doi.org/10.3390/medicina57101030
Wong TL, Weitzer DJ. Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)-A Systemic Review and Comparison of Clinical Presentation and Symptomatology. Medicina (Kaunas). 2021;57(5):418. https://doi.org/10.3390/medicina57050418
Deumer US, Varesi A, Floris V, et al. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): An Overview. J Clin Med. 2021;10(20):4786. https://doi.org/10.3390/jcm10204786
Komaroff AL. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: When Suffering Is Multiplied. Healthcare (Basel). 2021;9(7):919. https://doi.org/10.3390/healthcare9070919
Venus M, Holtforth MG. Short and Long Haul Pilots Rosters, Stress, Sleep Problems, Fatigue, Mental Health, and Well-Being. Aerosp Med Hum Perform. 2021;92(10):786-797. https://doi.org/10.3357/AMHP.5812.2021
Ormstad H, Simonsen CS, Broch L, et al. Chronic fatigue and depression due to multiple sclerosis: Immune-inflammatory pathways, tryptophan catabolites and the gut-brain axis as possible shared pathways. Mult Scler Relat Disord. 2020;46:102533. https://doi.org/10.1016/j.msard.2020.102533
Vasenina EE, Veryugina NI, Levin OS. Post-infectious asthenia and COVID-19. Terapiya. 2021;9(51):125-136. (In Russ.). https://doi.org/10.18565/therapy.2021.9.125-136
Slavich GM, Irwin MR. From stress to inflammation and major depressive disorder: a social signal transduction theory of depression. Psychol Bull. 2014;140(3):774-815. https://doi.org/10.1037/a0035302
Yong SJ. Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments. Infect Dis (Lond). 2021;53(10):737-754. https://doi.org/10.1080/23744235.2021.1924397
Carod-Artal FJ. Post-COVID-19 syndrome: epidemiology, diagnostic criteria and pathogenic mechanisms involved. Síndrome post-COVID-19: epidemiología, criterios diagnósticos y mecanismos patogénicos implicados. Rev Neurol. 2021;72(11):384-396. https://doi.org/10.33588/rn.7211.2021230
Song WJ, Hui CKM, Hull JH, et al. Confronting COVID-19-associated cough and the post-COVID syndrome: role of viral neurotropism, neuroinflammation, and neuroimmune responses. Lancet Respir Med. 2021;9(5):533-544. https://doi.org/10.1016/S2213-2600(21)00125-9
Ruiz-Pablos M, Paiva B, Montero-Mateo R, et al. Epstein-Barr Virus and the Origin of Myalgic Encephalomyelitis or Chronic Fatigue Syndrome. Front Immunol. 2021;12:656797. https://doi.org/10.3389/fimmu.2021.656797
Proal AD, VanElzakker MB. Long COVID or Post-acute Sequelae of COVID-19 (PASC): An Overview of Biological Factors That May Contribute to Persistent Symptoms. Front Microbiol. 2021;12:698169. https://doi.org/10.3389/fmicb.2021.698169
Tirelli U, Taibi R, Chirumbolo S. Post COVID syndrome: a new challenge for medicine. Eur Rev Med Pharmacol Sci. 2021;25(12):4422-4425. https://doi.org/10.26355/eurrev_202106_26154
Scordo KA, Richmond MM, Munro N. Post-COVID-19 Syndrome: Theoretical Basis, Identification, and Management. AACN Adv Crit Care. 2021;32(2):188-194. https://doi.org/10.4037/aacnacc2021492
Raanes EFW, Stiles TC. Associations Between Psychological and Immunological Variables in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Systematic Review. Front Psychiatry. 2021;12:716320. https://doi.org/10.3389/fpsyt.2021.716320
Menzies V, Kelly DL, Yang GS, et al. A systematic review of the association between fatigue and cognition in chronic noncommunicable diseases. Chronic Illn. 2021;17(2):129-150. https://doi.org/10.1177/1742395319836472
Li X, Julin P, Li TQ. Limbic Perfusion Is Reduced in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Tomography. 2021;7(4):675-687. https://doi.org/10.3390/tomography7040056
Nkiliza A, Parks M, Cseresznye A, et al. Sex-specific plasma lipid profiles of ME/CFS patients and their association with pain, fatigue, and cognitive symptoms. J Transl Med. 2021;19(1):370. https://doi.org/10.1186/s12967-021-03035-6
Badenoch JB, Rengasamy ER, Watson C, et al. Persistent neuropsychiatric symptoms after COVID-19: a systematic review and meta-analysis. Brain Commun. 2021;4(1):fcab297. https://doi.org/10.1093/braincomms/fcab297
Zielinski MR, Systrom DM, Rose NR. Fatigue, Sleep, and Autoimmune and Related Disorders. Front Immunol. 2019;10:1827. https://doi.org/10.3389/fimmu.2019.01827
Morris G, Maes M. Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics. BMC Med. 2013;11:205. https://doi.org/10.1186/1741-7015-11-205
Glassford JA. The Neuroinflammatory Etiopathology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Front Physiol. 2017;8:88. https://doi.org/10.3389/fphys.2017.00088
Wirth KJ, Scheibenbogen C, Paul F. An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. J Transl Med. 2021;19(1):471. https://doi.org/10.1186/s12967-021-03143-3
Wostyn P, De Deyn PP. The putative glymphatic signature of chronic fatigue syndrome: A new view on the disease pathogenesis and therapy. Med Hypotheses. 2018;118:142-145. https://doi.org/10.1016/j.mehy.2018.07.007
Abbott NJ, Pizzo ME, Preston JE, et al. The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’ system? Acta Neuropathol. 2018;135(3):387-407. https://doi.org/10.1007/s00401-018-1812-4
Benveniste H, Lee H, Volkow ND. The Glymphatic Pathway: Waste Removal from the CNS via Cerebrospinal Fluid Transport. Neuroscientist. 2017;23(5):454-465. https://doi.org/10.1177/1073858417691030
Nelson T, Zhang LX, Guo H, et al. Brainstem Abnormalities in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Scoping Review and Evaluation of Magnetic Resonance Imaging Findings. Front Neurol. 2021;12:769511. https://doi.org/10.3389/fneur.2021.769511
Thapaliya K, Marshall-Gradisnik S, Staines D, Barnden L. Diffusion tensor imaging reveals neuronal microstructural changes in myalgic encephalomyelitis/chronic fatigue syndrome. Eur J Neurosci. 2021;54(6):6214-6228. https://doi.org/10.1111/ejn.15413
Thapaliya K, Marshall-Gradisnik S, Staines D, Barnden L. Mapping of pathological change in chronic fatigue syndrome using the ratio of T1- and T2-weighted MRI scans. Neuroimage Clin. 2020;28:102366. https://doi.org/10.1016/j.nicl.2020.102366
Shan ZY, Kwiatek R, Burnet R, et al. Progressive brain changes in patients with chronic fatigue syndrome: A longitudinal MRI study. J Magn Reson Imaging. 2016;44(5):1301-1311. https://doi.org/10.1002/jmri.25283
Noor N, Urits I, Degueure A, et al. A Comprehensive Update of the Current Understanding of Chronic Fatigue Syndrome. Anesth Pain Med. 2021;11(3):e113629. https://doi.org/10.5812/aapm.113629
Richman S, Morris MC, Broderick G, et al. Pharmaceutical Interventions in Chronic Fatigue Syndrome: A Literature-based Commentary. Clin Ther. 2019;41(5):798-805. https://doi.org/10.1016/j.clinthera.2019.02.011
Sandler CX, Lloyd AR. Chronic fatigue syndrome: progress and possibilities. Med J Aust. 2020;212(9):428-433. https://doi.org/10.5694/mja2.50553
Che X, Brydges CR, Yu Y, et al. Evidence for Peroxisomal Dysfunction and Dysregulation of the CDP-Choline Pathway in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Preprint. medRxiv. 2022;2021.06.14.21258895. https://doi.org/10.1101/2021.06.14.21258895
Vila-Castelar C, Ly JJ, Kaplan L, et al. Attention Measures of Accuracy, Variability, and Fatigue Detect Early Response to Donepezil in Alzheimer’s Disease: A Randomized, Double-blind, Placebo-Controlled Pilot Trial. Arch Clin Neuropsychol. 2019;34(3):277-289. https://doi.org/10.1093/arclin/acy032
De Jesus Moreno Moreno M. Cognitive improvement in mild to moderate Alzheimer’s dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial. Clin Ther. 2003;25(1):178-193. https://doi.org/10.1016/s0149-2918(03)90023-3
Gavrilova SI, Alesenko AV, Kolyhalov IV, et al. Clinical and biological effects of Cereton in the treatment of amnestic mild cognitive impairment. Psychiatry. 2017;1(73):5-15. (In Russ.).
Starchina YuA. Use of Cereton in neurological care. Neurology, neuropsychiatry, psychosomatics. 2011;2:81-85. (In Russ.).