The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Nemkova S.A.

Pirogov Russian National Research Medical University

Neurological aspects of the consequences of COVID-19 in children

Authors:

Nemkova S.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(4): 23‑30

DOI: 10.17116/jnevro202212204123

Read: 5357 times

Contact the author
Table of contents

NEUROLOGICAL ASPECTS OF THE CONSEQUENCES OF COVID-19 IN CHILDREN
NEUROLOGICAL ASPECTS OF THE CONSEQUENCES OF COVID-19 IN CHILDREN

To cite this article:

Nemkova SA. Neurological aspects of the consequences of COVID-19 in children. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(4):23‑30. (In Russ.)
https://doi.org/10.17116/jnevro202212204123

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Abstract:

RESUME

To date, it is well established that neurological and neuropsychic disorders persist for a long time in a significant part of adult patients who have undergone COVID-19, despite the fact that there is much less information about the manifestations of postcovid syndrome (PCS) in children and adolescents. The review provides data on the features of the course of PCS in young patients, discusses the possibilities of treating such patients. The results of studies on the use of the drug Cortexin for the correction of cognitive and emotional disorders are analyzed.

Keywords:

COVID-19
postcovid syndrome
treatment
Cortexin

Authors:

Nemkova S.A.

Pirogov Russian National Research Medical University

Received:

14.03.2022

Accepted:

27.03.2022

Close metadata

References:

  1. Wang C, Horby PW, Hayden FG, Gao GF. A novel coronavirus outbreak of global health concern. Lancet. 2020;395(10223):470-473.  https://doi.org/10.1016/S0140-6736
  2. Zimmermann P, Pittet LF, Curtis N. How common is long COVID in children and adolescents? The Pediatric Infectious Disease Journal. 2021;40(12):482. 
  3. Features of clinical manifestations and treatment of the disease caused by a new coronavirus infection (COVID-19) in children. Guidelines, version 2. Ministerstvo Zdravoohraneniya RF, 2020. (In Russ).
  4. Blankenburg J, Wekenborg MK, Reichert J, et al. Mental health of Adolescents in the pandemic: long-COVID19 or long-pandemic syndrome? MedRxiv. 2021.2021.05.11.21257037. https://doi.org/10.1101/2021.05.11.21257037
  5. Gugliandolo A, Chiricosta L, Calcaterra V, Biasin M, Cappelletti G, Carelli S, et al. SARS-CoV-2 infected pediatric cerebral cortical neurons: transcriptomic analysis and potential role of toll-like receptors in pathogenesis. Int J Mol Sci. 2021;22:8059.
  6. Labò N, Ohnuki H, Tosato G. Vasculopathy and coagulopathy associated with SARS-CoV-2 infection. Cells. 2020;9:1583.
  7. Kempuraj D, Selvakumar GP,Ahmed ME, Raikwar SP,Thangavel R, Khan A, et al. COVID-19, mast cells, cytokine storm, psychological stress, and neuroinflammation. Neuroscientist. 2020;26:402-414. 
  8. Coperchini F, Chiovato L, Ricci G, Croce L, Magri F, Rotondi M. The cytokine storm in COVID-19: further advances in our understanding the role of specific chemokines involved. Cytokine Growth Factor Rev. 2021;58:82-91. 
  9. Cooper KW, Brann DH, Farruggia MC, Bhutani S, Pelligrino R, Tsukahara T, et al. COVID-19 and the chemical senses: supporting players take center tage. Neuron. 2020;107:219-233. 
  10. Meinhardt J, Radke J, Heppner FL. Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19. Nature Neuroscience. 2021;24:168-175. 
  11. COVID-19 rapid guideline: managing the long-term effects of COVID-19. NICE guideline December 2020. https://www.nice.org.uk/guidance/ng188.
  12. Marshall M. How COVID-19 can damage the brain. Nature. 2020;585:342-343. 
  13. Bryce C, Grimes Z, Pujadas E, Ahuja S, et al. Pathophysiology of SARS-CoV-2: targeting of endothelial cells renders a complex disease with thrombotic microangiopathy and aberrant immune response. The Mount Sinai COVID-19 autopsy experience. Mod Pathol. 2021;34(8):1456-1467. https://doi.org/10.1038/s41379-021-00793-y
  14. Camargo-Martínez W, Lozada-Martínez I, Escobar-Collazos A, Navarro-Coronado A, et al. Post-COVID 19 neurological syndrome: implications for sequelae’s treatment. J Clin Neurosci. 2021;88:219-225. 
  15. https://www. rnmot.ru›public/uploads/2022/rnmot/ Features of the course of Long-KOVID infection. Therapeutic and rehabilitation measures. Methodological recommendations. M. 2021. (In Russ).
  16. Carfi A, Bernabei R, Landi F, et al. Persistent symptoms in patients after acute COVID‐19. JAMA. 2020;324(6):603‐605. 
  17. Taquet M, Geddes JR, Husain M, et al. 6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records. The Lancet Psychiatry. 2021;8(5):416-427.  https://doi.org/10.1016/S2215-0366(21)00084-5
  18. Putilina MV, Mutovina ZYu, Kurushina OV, et al. Determination of the prevalence of postcovid syndrome and assessment of the effectiveness of the drug Cortexin in the treatment of neurological disorders in patients with postcovid syndrome. Results of the multicenter clinical and epidemiological observational program CORTEX. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2022;122(1):84-90. (In Russ.). https://doi.org/10.17116/jnevro202212201184
  19. Iqbala FM, Lama K, Sounderajaha V, Clarkeb JM, et al. Characteristics and predictors of acute and chronic post-COVID syndrome: A systematic review and meta-analysis. E Clinical Medicine. 2021;(36):100899. https://doi.org/10.1016/j.eclinm.2021.100899
  20. Ahmed JO, Ahmed SA, Hassan MN, Fahmi H. Post COVID-19 neurological complications; a meta-analysis. Annals of Medicine and Surgery. 2022;3:103440. https://doi.org/10.1016/j.amsu.2022.103440
  21. Ludvigsson JF. Case report and systematic review suggest that children may experience similar long‐term effects to adults after clinical COVID‐19. Acta Paediatr. 2021;110(3):914‐921.  https://doi.org/10.1111/apa.15673
  22. Buonsenso D, Munblit D, De Rose C, Sinatti D, Ricchiuto A, Carfi A, Valentini P. Preliminary evidence on long COVID in children. Acta Paediatr. 2021;110(7):2208-2211. https://doi.org/10.1101/2021.01.23.21250375
  23. LaRovere KL, Riggs BJ, Poussaint TY, et al. Neurologic Involvement in children and adolescents hospitalized in the United States for COVID-19 or multisystem inflammatory syndrome. JAMA Neurol. 2021;78(5):536-547.  https://doi.org/10.1001/jamaneurol.2021.0504
  24. Miller F, Nguyen V, Navaratnam AMD, et al. Prevalence of persistent symptoms in children during the COVID-19 pandemic: evidence from a household cohort study in England and Wales. BMJ. 2021;June,2.  https://doi.org/10.1101/2021.05.28.21257602
  25. Radtke T, Ulyte A, Puhan MA, Kriemler S. Long-term symptoms after SARS-CoV-2 infection in children and adolescents. JAMA. 2021;34(8):23-29.  https://doi.org/10.1001/jama.2021.11880
  26. Stephenson T, Shafran R, De Stavola B, et al. Long COVID — the physical and mental health of children and non-hospitalised young people 3 months after SARS-CoV-2 infection; a national matched cohort study (The CLoCk) Study. Researchsquare. BMJ. 2021;11(8):e052838. https://doi.org/10.21203/rs.3.rs-798316/v1
  27. Brackel LH, Lap CR, Buddingh EP, et al. Pediatric long‐COVID: An overlooked phenomenon? Pediatric Pulmonology. 2021;56(8):2495-2502.
  28. Molteni E, Sudre CH, Canas LS, et al. Illness duration and symptom profile in symptomatic UK school-aged children tested for SARS-CoV-2. Lancet Child Adolesc Health. 2021;3:45-49.  https://doi.org/10.1016/S2352-4642(21)00198-X
  29. Buonsenso D, Espuny Pujol F, Munblit D, Mcfarland S, Simpson F. Clinical characteristics, activity levels and mental health problems in children with long COVID: a survey of 510 children. Preprints. 2021;2021030271  https://doi.org/10.20944/preprints202103.0271.v1
  30. Consiglio CR, Cotugno N, Sardh F. The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19. Cell. 2020;183(4):968-981. 
  31. Blomberg B, Mohn KG, Brokstad KA, et al. Long COVID in a prospective cohort of home-isolated patients. Nat Med. 2021 June, 23.  https://doi.org/10.1038/s41591-021-01433-3
  32. Smane L, Stars I, Pucuka Z, et al. Persistent clinical features in paediatric patients after SARS-CoV-2 virological recovery: a retrospective population-based cohort study from a single centre in Latvia. BMJ Paediatr Open. 2020;4:e000905.
  33. Nogueira López J, Grasa C, Calvo C, et al. Long-term symptoms of COVID-19 in children. Acta Paediatr. 2021;110:2282-2283.
  34. Lin JE, Taylor AA, Sewell B, et al. Neurological issues in children with COVID-19. Neuroscience Letters Volume. 2021;743:56-61. 
  35. Kholin AA, Zavadenko NN, Nesterovskiy YuE, Kholina EA, Zavadenko AN, Khondkaryan GSh. Features of neurological manifestations of the COVID-19 in children and adults. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2020;120(9):114-120. (In Russ.). https://doi.org/10.17116/jnevro2020120091114
  36. Carl E. Stafstrom Neurological effects of COVID-19 in infants and children. DMCN. 2022;3;34-39.  https://doi.org/10.1111/dmcn.15185
  37. Nikolopoulou GB, Maltezou HC. COVID-19 in children: where do we stand? Arch Med Res. 2022;53:1-8. 
  38. Sa M, Mirza L, Carter M, Carlton Jones L, Gowda V, Handforth J, et al. Systemic inflammation is associated with neurologic involvement in pediatric inflammatory multisystem syndrome associated with SARS-CoV-2. Neurol Neuroimmunol Neuroinflamm. 2021;8:e999.
  39. Wang JG, Zhong ZJ, Li M, et al. Coronavirus disease 2019-related multisystem inflammatory syndrome in children: a systematic review and meta-analysis. Biochem Res Int. 2021:5596727.
  40. Abrams JY, Godfred-Cato SE, Oster ME, Chow EJ, Koumans EH, Bryant B, et al. Multisystem inflammatory syndrome in children associated with severe acute respiratory syndrome coronavirus 2: a systematic review. J Pediatr. 2020;226:45-54. 
  41. Panda PK, Sharawat IK, Panda P, Natarajan V, Bhakat R, Dawman L. Neurological complications of SARS-CoV-2 infection in children: a systematic review and meta-analysis. J Trop Pediatr. 2021;67:fmaa070.
  42. O’Loughlin L, Toledo NA, Budrie L, Waechter R, Rayner J. A systematic review of severe neurological manifestations in pediatric patients with coexisting SARS-CoV-2 infection. Neurol Int. 2021;13:410-427. 
  43. Malyavin AG. Consequences of COVID-19 coronavirus infection: prevalence and approaches to the treatment of Long-COVID symptoms. Terapiya. 2021;10:23-28. (In Russ).
  44. Nemkova SA, Maslova OI, Karkashadze GA, et al.The use of a polypeptide stimulator in the complex treatment of cognitive disorders in children with diseases of the central nervous system. Pediatricheskaya farmakologiya. 2012;9(5):80-86. (In Russ.).
  45. Nemkova SA, Zavadenko NN, Suvorinova NYu. The use of cortexin in complex neurorehabilitation in children. Rossijskij Vestnik Perinatologii i Pediatrii. 2015;2:37-44. (In Russ.).
  46. Platonova TN. The use of cortexin in the complex treatment of diseases of the nervous system in children. M.: Terra medica; 2000;4:50-53. (In Russ.).
  47. Stepanichev MYu, Gulyaeva NV. Effect of the drug Cortexin on free radical oxidation and inflammatory processes in rats with normal and accelerated aging. Nejrohimiya. 2018;2(35):11-18. (In Russ.).
  48. Rumyantseva SA, Afanasyev VV, Silina EV, et al. Methods of rational pharmacocorrection and prevention of secondary ischemia and vasospasm in patients with cerebral circulatory disorders of various types. Trudnyj Pacient. 2010;6(7):19-25. (In Russ.).
  49. Yakovlev AA, Gulyaeva NV. Molecular partners of Cortexin in the brain. Nejrohimiya. 2017;1:91-96. (In Russ.).
  50. Chutko LS, Kropotov YuD, Surushkina SYu, et el. The use of Cortexin in neurasthenia in adolescents. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2006;(2):50-51. (In Russ.).
  51. Zykov VP, Serebrennikova EB, Panchenko TN, Sycheva YaB. Results of a multicenter study of the effectiveness of cortexin in cognitive dysfunction in children. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2018;118(3):27-31. (In Russ.). https://doi.org/10.17116/jnevro20181183127-31
  52. Shabalov NP, Skoromets AA, Platonova TN. Long-term use of cortexin in pediatric neurological practice. Terra Medica. 2004;1:2-4. (In Russ.).
  53. Yang C, Hawkins KE, Doré S, Candelario-Jalil E. Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke. Am J Physiol Cell Physiol. 2019;316(2):135-153. 
  54. Chiesa-Estomba CM, Lechien JR, Radulesco T, Michel J. Patterns of Gustatory Recovery in Patients Affected by the COVID-19 Outbreak. Virologica Sinica. 2020;35(6):45-49.  https://doi.org/10.1007/s12250-020-00272-9
  55. Philpott CM, Erskine SE, Clark A, Leeper A. A randomised controlled trial of sodium citrate spray for non-conductive olfactory disorders. Clin Otolaryngol. 2017;42(6):1295-1302.
  56. dos Santos LMJ. Can vitamin B12 be an adjuvant to COVID-19 treatment? GSC Biological and Pharmaceutical Sciences. 2020;11(03):001-005.  https://doi.org/10.30574/gscbps.2020.11.3.0155
  57. Bousquet PJ, Akdis CA, Jutel M, Bachert C. Intranasal corticosteroids in allergic rhinitis in COVID-19 infected patients: An ARIA-EAACI statement. Allergy. 2020;75(10):2440-2444. https://doi.org/10.1111/all.14302
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.