The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Khachatryan R.G.

Almazov National Medical Research Center

Alekseeva T.M.

Almazov National Medical Research Center

Khachatryan V.A.

Almazov National Medical Research Center

Sebelev K.I.

Almazov National Medical Research Center

Alekseeva N.P.

Almazov National Medical Research Center

Clinical features of temporal lobe epilepsy with involvement of the insular lobe

Authors:

Khachatryan R.G., Alekseeva T.M., Khachatryan V.A., Sebelev K.I., Alekseeva N.P.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(6): 7‑12

DOI: 10.17116/jnevro20211210617

Views: 2820

Downloaded: 114

Download PDF (RU)
Contact the author
Table of contents

To cite this article:

Khachatryan RG, Alekseeva TM, Khachatryan VA, Sebelev KI, Alekseeva NP. Clinical features of temporal lobe epilepsy with involvement of the insular lobe. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(6):7‑12. (In Russ.)
https://doi.org/10.17116/jnevro20211210617

 
МСФ на ЯМ
Close metadata
Recommended articles:
Expe­rimental study of the influence of phenozanic acid and its combination with valproic acid on the deve­lopment of the epileptic system. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(3):104-113
Long-term follow-up of adult patients with serial and status course of epileptic seizures. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(4):63-68
Epilepsy with PCDH19 muta­tion: poly­pharmacy as a consequence of the complexity and dive­rsity of pathogenesis mechanisms. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(7):51-55
Study of the practice of prescribing phenosanic acid in epilepsy acco­mpanied by asthenic diso­rders. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(7):89-97
Personality profile caused by epilepsy acco­rding to the «Big Five» model. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(10):16-21
Brain microstructural abno­rmalities asse­ssed by diffusion kurtosis MRI in patients with focal temporal lobe epilepsy. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):171-177
Ototoxicity caused by anti-epileptic drugs. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):14-19
Abse­nce status epilepticus in adults. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):47-56
Como­rbid anxiety diso­rders in patients with neurological pathology: current state of the problem and the role of etifoxine in treatment stra­tegy. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):126-136
Auto­nomic cardiovascular diso­rders in patients with epileptic and psychogenic non-epileptic seizures: a pilot study. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(2):13-20

OBJECTIVE

To determine the clinical features of the course of the disease when the insular lobe is involved in the epileptic process.

MATERIAL AND METHODS

A comparative analysis of the results of diagnosis and treatment of 55 patients with temporal lobe epilepsy and 46 patients with temporal plus epilepsy was carried out. The results of neuroimaging, clinical and EEG studies were compared.

RESULTS

Autonomic paroxysms of nausea and hypersalivation, skin changes, simple motor seizures, emotional seizure and sensory paroxysms are the most reliable signs of the involvement of the insular lobe in the epileptic process in temporal plus epilepsy. For ‘pure’ temporal lobe epilepsy, cognitive paroxysms of the déjà vu and aura are common. When the insular lobe is involved in the epileptic process, the seizures have a reliably high frequency, polymorphism and are more complex by structure.

CONCLUSION

Paroxysmal syndrome in temporal plus epilepsy with involvement of the insular lobe undergoes significant changes in the form of increased seizures and the appearance of specific seizures and characteristic polymorphism.

Keywords:

insula
epilepsy
insular epilepsy
surgical treatment of epilepsy

Authors:

Khachatryan R.G.

Almazov National Medical Research Center

Alekseeva T.M.

Almazov National Medical Research Center

Khachatryan V.A.

Almazov National Medical Research Center

Sebelev K.I.

Almazov National Medical Research Center

Alekseeva N.P.

Almazov National Medical Research Center

Received:

05.05.2020

Accepted:

29.06.2020

List of references:

  1. Insard J, Guenot M, Mauguire F. Clinical manifestations of insular lobe seizures: a stereo-electroencephalographic study. Epilepsia. 2004;45:1079-1090. https://doi.org/10.1111/j.0013-9580.2004.68903.x
  2. Penfield W, Faulk ME. The insula: further observations on its function. Brain. 1955;78:445-470.  https://doi.org/10.1093/brain/78.4.445
  3. Ostrowsky K, Isnard J, Ryvelin Ph, et al. Functional mapping of the insular cortex: clinical implication in temporal lobe epilepsy. Epilepsia. 2000; 41(6):681-686.  https://doi.org/10.1111/j.1528-1157.2000.tb00228.x
  4. Ryvlin P, Kahane P. The hidden causes of surgery-resistant temporal lobe epilepsy: extratemporal or temporal plus? Curr Opin Neurol. 2005;18:125-127.  https://doi.org/10.1097/01.wco.0000162852.22026.6f
  5. Fisher RS, Cross JH, French JA, et al. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017;58(4):522-530.  https://doi.org/10.1111/epi.13670
  6. Alexeyeva N, Smirnov I, Ananyevskaya (Gracheva) P, Martynov B. The finitely geometric symptom analysis in the glioma survival study. Proc. of the 2nd International Conference on BioMedical Engineering and Informatics (BMEI). 2009;1-4.  https://doi.org/10.1109/BMEI.2009.5305560
  7. Proserpio P, Cossu M, Francione S. Insular-opercular seizures manifesting with sleep-related paroxysmal motor behaviors: a stereo-EEG study. Epilepsia. 2011;52:1781-1791. https://doi.org/10.1111/j.1528-1167.2011.03254.x
  8. Aghakhani Y, Rosati A, Dubeau F, et al. Patients with temporoparietal ictal symptoms and inferomesial EEG do not benefit from anterior temporal resection. Epilepsia. 2004;45:230-236.  https://doi.org/10.1111/j.0013-9580.2004.43003.x
  9. Jobst BC, Gonzalez-Martinez J, Isnard J, et al. The insula and its epilepsies. Epilepsy Currents. 2019;19(1):11-21.  https://doi.org/10.1177/1535759718822847
  10. Stephani C, Fernandez-Baca Vaca G, Maciunas R, et al. Functional neuroanatomy of the insular lobe. Brain Struc Funct. 2011;216:137-149.  https://doi.org/10.1007/s00429-010-0296-3
  11. Barba C, Barbati G, Minotti L, et al. Ictal clinical and scalp-EEG findings differentiating temporal lobe epilepsies from temporal ‘plus’ epilepsies. Brain. 2007;130:1957-1967. https://doi.org/10.1093/brain/awm108
  12. Isnard J, Ryvlin P, Mauguière F. Insular epilepsy. In: Luders HO, ed. Textbook of Epilepsy Surgery. 1st edn. London: CRC Press; 2008;39:320-334.  https://doi.org/10.3109/9780203091708
  13. Montavont A, Mauguiere F, Mazzola L, et al. On the origin of painful somatosensory seizures. Neurology. 2015;84(6):594-601.  https://doi.org/10.1212/WNL.0000000000001235
  14. Afif A, Minotti L, Kahane P, Hoffman D. Anatomofunctional organization of insular cortex: a study using intracerebral electrical stimulation in epileptic parents. Epilepsia. 2010;51:2305-2310. https://doi.org/10.1111/j.1528-1167.2010.02755.x
  15. Catenoix H, Isnard J, Guenot M, et al. The role of the anterior insular cortex in ictal vomiting: A stereotactic encephalography study. Epilepsy Behav. 2008;13(3):560-563.  https://doi.org/10.1016/j.yebeh.2008.06.019
  16. Tufenkjian K, Lüders HO. Seizure Semiology: Its Value and Limitations in Localizing the Epileptogenic Zone. J Clin Neurol. 2012;8:243-250.  https://doi.org/10.3988/jcn.2012.8.4.243
  17. Mazzola L, Mauguiere F, Isnard J. Electrical stimulations of the human insula: their contribution to the ictal semiology of insular seizures. J Clin Neurophysiol. 2017;34(4):307-314.  https://doi.org/10.1097/WNP.0000000000000382
  18. Penfield W, Jasper H. Epilepsy and functional anatomy of the human brain. Boston: Little, Brown; 1954.
  19. Landtblom A-M, Lindehammar H, Karlsson H, Craig AD. Insular cortex activation in a patient with “sensed presence”/ecstatic seizures. Epilepsy Behav. 2011;20:714-718.  https://doi.org/10.1016/j.yebeh.2011.01.031
  20. Blair RD. Temporal lobe epilepsy semiology. Epilepsy Res Treat. 2012; 2012:751510. https://doi.org/10.1155/2012/751510

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.