The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Mamedov I.S.

GBU Scientific and Practical Center for Specialized assistance to children named after V.F. Voino-Yasenetsky DZM

Perevezentsev O.A.

GBU Scientific and Practical Center for Specialized assistance to children named after V.F. Voino-Yasenetsky DZM;
Rostov State Medical University of the Ministry of Health of the Russian Federation

Kulakova E.G.

GBU Scientific and Practical Center for Specialized assistance to children named after V.F. Voino-Yasenetsky DZM

Zolkina I.V.

Archimedes Clinic of New Medical Technologies LLC

Tkacheva M.I.

Archimedes Clinic of New Medical Technologies LLC

Paramonov S.A.

Archimedes Clinic of New Medical Technologies LLC

Simenel E.S.

Archimedes Clinic of New Medical Technologies LLC

Tatarinov P.A.

GBU Scientific and Practical Center for Specialized assistance to children named after V.F. Voino-Yasenetsky DZM;
Pirogov Russian National Research Medical University Ministry of HealthRF

Krapivkin A.I.

GBU Scientific and Practical Center for Specialized assistance to children named after V.F. Voino-Yasenetsky DZM

A personalized approach to the diagnosis of epilepsy in obese children

Authors:

Mamedov I.S., Perevezentsev O.A., Kulakova E.G., Zolkina I.V., Tkacheva M.I., Paramonov S.A., Simenel E.S., Tatarinov P.A., Krapivkin A.I.

More about the authors

Journal: Laboratory Service. 2025;14(1): 5‑12

DOI: 10.17116/labs2025140115

Read: 765 times

Buy for 300₽
Contact the author
Table of contents

A PERSONALIZED APPROACH TO THE DIAGNOSIS OF EPILEPSY IN OBESE CHILDREN
A PERSONALIZED APPROACH TO THE DIAGNOSIS OF EPILEPSY IN OBESE CHILDREN

To cite this article:

Mamedov IS, Perevezentsev OA, Kulakova EG, et al. . A personalized approach to the diagnosis of epilepsy in obese children. Laboratory Service. 2025;14(1):5‑12. (In Russ.)
https://doi.org/10.17116/labs2025140115

 
Подписка 2025 Лабораторная служба (Laboratory Service)
МСФ на ЯМ
Использование инфографики авторами научных работ
Recommended articles:
Personality profile caused by epilepsy acco­rding to the «Big Five» model. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(10):16-21
Features of como­rbidity pathology in young people. Russian Journal of Preventive Medi­cine. 2024;(11):63-69
Modern view on the etiology of gallstone disease in children. Russian Journal of Evidence-Based Gastroenterology. 2024;(4):59-68
Brain microstructural abno­rmalities asse­ssed by diffusion kurtosis MRI in patients with focal temporal lobe epilepsy. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):171-177
Options for the surgical technique of lapa­roscopic sleeve gastrectomy for prevention and treatment of gastroesophageal reflux in patients with obesity. Endo­scopic Surgery. 2024;(6):57-68
Application of modern methods for acti­vation of brain functions in obese patients (literature review). Problems of Balneology, Physiotherapy and Exercise Therapy. 2024;(6):54-61
Ototoxicity caused by anti-epileptic drugs. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):14-19
Abse­nce status epilepticus in adults. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):47-56
Como­rbid anxiety diso­rders in patients with neurological pathology: current state of the problem and the role of etifoxine in treatment stra­tegy. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):126-136
Comparative analysis of the state of the microvasculature of the oral mucosa in persons with meta­bolic syndrome in the aspect of orthopedic dental reha­bilitation. Stomatology. 2024;(6-2):15-22
Abstract:

INTRODUCTION

Epilepsy is one of the important problems of modern neurology. Various epileptic syndromes can be combined with other diseases, in particular, with obesity. Currently, various aspects of the etiopathogenesis of epileptic seizures against the background of obesity are actively studied.

THE AIM OF THE WORK

Is to develop an approach to personalized biochemical diagnostics of epilepsy in children based on potential changes in the profile of organic acids in urine.

MATERIALS AND METHODS

The study included 22 patients aged 1 to 16 years (mean age 11.7 years): 16 patients with various epileptic syndromes against the background of obesity and 6 patients in the comparison group. HPLC-MS. Results carried out the study of the profile of 60 organic acids in urine. In the group of patients with epilepsy against the background of obesity, excess of the upper reference limit of a number of markers of the Krebs cycle (fumaric and 2-ketoglutaric acids), bacterial dysbiosis and lactic acid were detected. Also in the patient sample, in contrast to the comparison group, an increase in the level of mitochondrial dysfunction markers was found.

RESULTS

In the group of patients with epilepsy against the background of obesity, the upper reference limit of a number of markers of the Krebs cycle (fumaric and 2-ketoglutaric acids), bacterial dysbiosis and lactic acid were exceeded. Also in the sample of patients, in contrast to the comparison group, an increase in the level of markers of mitochondrial dysfunction was found.

CONCLUSION

Thus, we identified changes in a number of metabolic markers associated with epilepsy in children against the background of obesity.

Keywords:

epilepsy
obesity
organic acids
HPLC/MS

Authors:

Mamedov I.S.

GBU Scientific and Practical Center for Specialized assistance to children named after V.F. Voino-Yasenetsky DZM

Perevezentsev O.A.

GBU Scientific and Practical Center for Specialized assistance to children named after V.F. Voino-Yasenetsky DZM;
Rostov State Medical University of the Ministry of Health of the Russian Federation

Kulakova E.G.

GBU Scientific and Practical Center for Specialized assistance to children named after V.F. Voino-Yasenetsky DZM

Zolkina I.V.

Archimedes Clinic of New Medical Technologies LLC

Tkacheva M.I.

Archimedes Clinic of New Medical Technologies LLC

Paramonov S.A.

Archimedes Clinic of New Medical Technologies LLC

Simenel E.S.

Archimedes Clinic of New Medical Technologies LLC

Tatarinov P.A.

GBU Scientific and Practical Center for Specialized assistance to children named after V.F. Voino-Yasenetsky DZM;
Pirogov Russian National Research Medical University Ministry of HealthRF

Krapivkin A.I.

GBU Scientific and Practical Center for Specialized assistance to children named after V.F. Voino-Yasenetsky DZM

Received:

16.12.2024

Accepted:

03.02.2025

Close metadata

References:

  1. Li YX, Guo W, Chen RX, Lv XR, Li Y. The relationships between obesity and epilepsy: A systematic review with meta-analysis. PLoS One. 2024 Aug 9;19(8):e0306175. https://doi.org/10.1371/journal.pone.0306175
  2. Beghi E. The Epidemiology of Epilepsy. Neuroepidemiology. 2020;54(2):185-191.  https://doi.org/10.1159/000503831
  3. Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, Engel J Jr, Forsgren L, French JA, Glynn M, Hesdorffer DC, Lee BI, Mathern GW, Moshé SL, Perucca E, Scheffer IE, Tomson T, Watanabe M, Wiebe S. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014 Apr;55(4):475-482.  https://doi.org/10.1111/epi.12550.E
  4. Pong AW, Xu KJ, Klein P. Recent advances in pharmacotherapy for epilepsy. Curr Opin Neurol. 2023 Apr 1;36(2):77-85.  https://doi.org/10.1097/WCO.0000000000001144
  5. Novak A, Vizjak K, Rakusa M. Cognitive Impairment in People with Epilepsy. J Clin Med. 2022 Jan 5;11(1):267.  https://doi.org/10.3390/jcm11010267
  6. Villanueva V, Artal J, Cabeza-Alvarez CI, Campos D, Castillo A, Flórez G, Franco-Martin M, García-Portilla MP, Giráldez BG, Gotor F, Gutiérrez-Rojas L, Albanell AM, Paniagua G, Pintor L, Poza JJ, Rubio-Granero T, Toledo M, Tortosa-Conesa D, Rodríguez-Uranga J, Bobes J. Proposed Recommendations for the Management of Depression in Adults with Epilepsy: An Expert Consensus. Neurol Ther. 2023 Apr;12(2):479-503.  https://doi.org/10.1007/s40120-023-00437-0.Epub2023Jan24
  7. Sidhu HS, Srinivasa R, Sadhotra A. Evaluate the effects of antiepileptic drugs on reproductive endocrine system in newly diagnosed female epileptic patients receiving either Valproate or Lamotrigine monotherapy: A prospective study. Epilepsy Res. 2018 Jan;139:20-27.  https://doi.org/10.1016/j.eplepsyres.2017.10.016
  8. Gotlib D, Ramaswamy R, Kurlander JE, DeRiggi A, Riba M. Valproic Acid in Women and Girls of Childbearing Age. Curr Psychiatry Rep. 2017 Sep;19(9):58.  https://doi.org/10.1007/s11920-017-0809-3
  9. Lai W, Shen N, Zhu H, He S, Yang X, Lai Q, Li R, Ji S, Chen L. Identifying risk factors for polycystic ovary syndrome in women with epilepsy: A comprehensive analysis of 248 patients. J Neuroendocrinol. 2023 Mar;35(3):e13250. https://doi.org/10.1111/jne.13250
  10. Zhou K, Yang H, Chen R, Wang W, Qu Z. Causal relationship among obesity and body fat distribution and epilepsy subtypes. Front Neurol. 2022 Oct 26;13:984824. https://doi.org/10.3389/fneur.2022.984824
  11. Buro AW, Salinas-Miranda A, Marshall J, Gray HL, Kirby RS. Obesity and neurodevelopmental and mental health conditions among adolescents aged 10-17 years: The National Survey of Children’s Health 2017-2018. J Paediatr Child Health. 2022 Oct;58(10):1753-1759. https://doi.org/10.1111/jpc.16081
  12. Lee DH, Kim SY, Park JE, Jeon HJ, Park JH, Kawachi I. Nationwide trends in prevalence of underweight, overweight, and obesity among people with disabilities in South Korea from 2008 to 2017. Int J Obes (Lond). 2022 Mar;46(3):613-622.  https://doi.org/10.1038/s41366-021-01030-x
  13. Lee Y, Ahn Y, Cucullo L. Impact of Physical Activity and Medication Adherence on the Seizure Frequency and Quality of Life of Epileptic Patients: A Population Study in West Texas. Biomed Res Int. 2022 Jan 18;2022:4193664. https://doi.org/10.1155/2022/4193664
  14. Chen M, Wu X, Zhang B, Shen S, He L, Zhou D. Associations of overweight and obesity with drug-resistant epilepsy. Seizure. 2021 Nov;92:94-99.  https://doi.org/10.1016/j.seizure.2021.07.019
  15. Nazish S. Obesity and metabolic syndrome in patients with epilepsy, their relation with epilepsy control. Ann Afr Med. 2023 Apr-Jun;22(2):136-144.  https://doi.org/10.4103/aam.aam_139_22
  16. Pfeifer MT, Kostev K, Doege C. Sex-related associations between body mass index and the incidence of epilepsy. Epilepsy Behav. 2022 Nov;136:108926. https://doi.org/10.1016/j.yebeh.2022.108926
  17. Janousek J, Barber A, Goldman L, Klein P. Obesity in adults with epilepsy. Epilepsy Behav. 2013 Sep;28(3):391-394.  https://doi.org/10.1016/j.yebeh.2013.05.012
  18. Adane T, Melese M, Tesfaye E, Ambelu A, Getnet M, Sinamaw D, Esubalew D, Yismaw Y. Electrocardiogram Abnormalities and Associated Factors Among People with and without Epilepsy Attending the Outpatient Department at Referral Hospitals in Amhara Regional State, Northern Ethiopia, 2022: Institutional-Based Comparative Cross-Sectional Study. Neuropsychiatr Dis Treat. 2023 May 30;19:1285-1302. https://doi.org/10.2147/NDT.S408812
  19. Inaloo S, Saki F, Paktinat M, Katibeh P, Nemati H, Ranjbar Omrani G. Evaluation of The Metabolic Syndrome Criteria And Body Composition in Ambulatory Children with Epilepsy UsingSodium Valproate and Carbamazepine In Southern Iran: A Case-Control Study. Iran J Child Neurol. 2020 Summer;14(3):47-56. 
  20. Li YX, Guo W, Chen RX, Lv XR, Li Y. The relationships between obesity and epilepsy: A systematic review with meta-analysis. PLoS One. 2024 Aug 9;19(8):e0306175. https://doi.org/10.1371/journal.pone.0306175
  21. Mukhin K.Yu., Petrov A.S., Mironov M.B. Epileptic syndromes. Diagnosis and therapeutic guideline for doctors. M.: Sistemnye resheniya. 2008;223 (In Russ.).
  22. Wolf NI, García-Cazorla A, Hoffmann GF. Epilepsy and inborn errors of metabolism in children. J Inherit Metab Dis. 2009 Oct;32(5):609.  https://doi.org/10.1007/s10545-009-1171-3
  23. Reddy C, Saini AG. Metabolic Epilepsy. Indian J Pediatr. 2021 Oct;88(10):1025-1032. https://doi.org/10.1007/s12098-020-03510-w
  24. Putilina MV. Mitochondrial dysfunction. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(9):48-53. (In Russ.). https://doi.org/10.17116/jnevro202212209148
  25. Khurana DS, Valencia I, Goldenthal MJ, Legido A. Mitochondrial dysfunction in epilepsy. Semin Pediatr Neurol. 2013 Sep;20(3):176-187.  https://doi.org/10.1016/j.spen.2013.10.001
  26. Xia W, Veeragandham P, Cao Y, Xu Y, Rhyne TE, Qian J, Hung CW, Zhao P, Jones Y, Gao H, Liddle C, Yu RT, Downes M, Evans RM, Rydén M, Wabitsch M, Wang Z, Hakozaki H, Schöneberg J, Reilly SM, Huang J, Saltiel AR. Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation. Nat Metab. 2024 Feb;6(2):273-289.  https://doi.org/10.1038/s42255-024-00978-0.Epub2024Jan29
  27. de Mello AH, Costa AB, Engel JDG, Rezin GT. Mitochondrial dysfunction in obesity. Life Sci. 2018 Jan 1;192:26-32.  https://doi.org/10.1016/j.lfs.2017.11.019
  28. Feng J, Li L, Ou Z, Li Q, Gong B, Zhao Z, Qi W, Zhou T, Zhong J, Cai W, Yang X, Zhao A, Gao G, Yang Z. IL-25 stimulates M2 macrophage polarization and thereby promotes mitochondrial respiratory capacity and lipolysis in adipose tissues against obesity. Cell Mol Immunol. 2018 May;15(5):493-505.  https://doi.org/10.1038/cmi.2016.71
  29. Witkowska-Sędek E, Kucharska A, Rumińska M, Pyrżak B. Thyroid dysfunction in obese and overweight children. Endokrynol Pol. 2017;68(1):54-60.  https://doi.org/10.5603/EP.2017.0007
  30. McNamara NA, Romanowski EMF, Olson DP, Shellhaas RA. Bone Health and Endocrine Comorbidities in Pediatric Epilepsy. Semin Pediatr Neurol. 2017 Nov;24(4):301-309.  https://doi.org/10.1016/j.spen.2017.10.005
  31. Nishiyama M, Takami Y, Ishida Y, Tomioka K, Tanaka T, Nagase H, Nakagawa T, Tokumoto S, Yamaguchi H, Toyoshima D, Maruyama A, Nozu K, Nishimura N, Iijima K. Lipid and thyroid hormone levels in children with epilepsy treated with levetiracetam or carbamazepine: A prospective observational study. Epilepsy Behav. 2019 Jan;90:15-19.  https://doi.org/10.1016/j.yebeh.2018.11.003
  32. Elia M, Klepper J, Leiendecker B, Hartmann H. Ketogenic Diets in the Treatment of Epilepsy. Curr Pharm Des. 2017;23(37): 5691-5701. https://doi.org/10.2174/1381612823666170809101517
  33. Cameron T, Allan K, Kay Cooper. The use of ketogenic diets in children living with drug-resistant epilepsy, glucose transporter 1 deficiency syndrome and pyruvate dehydrogenase deficiency: A scoping review. J Hum Nutr Diet. 2024 Aug;37(4):827-846.  https://doi.org/10.1111/jhn.13324
  34. Mamedov IS, Sukhorukov VS, Zolkina IV, Savina MI, Nikolaeva EA. Evaluation of mass spectrometric indicators for the differential diagnosis of inherited disorders of organic acid metabolism in children. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2019;64(1):61-67. (In Russ.). https://doi.org/10.21508/1027-4065-2019-64-1-61-67
  35. Ziegler SG, Kim J, Ehmsen JT, Vernon HJ. Inborn errors of amino acid metabolism — from underlying pathophysiology to therapeutic advances. Dis Model Mech. 2023 Nov 1;16(11):dmm050233. https://doi.org/10.1242/dmm.050233
  36. Huang C, Chu C, Peng Y, Zhang N, Yang Z, You J, Wei F. Correlations between gastrointestinal and oral microbiota in children with cerebral palsy and epilepsy. Front Pediatr. 2022 Nov 4;10:988601. https://doi.org/10.3389/fped.2022.988601
  37. Gong X, Cai Q, Liu X, An D, Zhou D, Luo R, Peng R, Hong Z. Gut flora and metabolism are altered in epilepsy and partially restored after ketogenic diets. Microb Pathog. 2021 Jun;155:104899. https://doi.org/10.1016/j.micpath.2021.104899
  38. Lee K, Kim N, Shim JO, Kim GH. Gut Bacterial Dysbiosis in Children with Intractable Epilepsy. J Clin Med. 2020 Dec 22;10(1):5.  https://doi.org/10.3390/jcm10010005
  39. Dahlin M, Prast-Nielsen S. The gut microbiome and epilepsy. EBioMedicine. 2019 Jun;44:741-746.  https://doi.org/10.1016/j.ebiom.2019.05.024
  40. Coman D, Kranc KR, Christodoulou J. Fumarate Hydratase Deficiency. 2006 Jul 5 [updated 2020 Apr 23]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, eds. GeneReviews [Internet]. Seattle (WA): University of Washington, Seattle; 1993—2024. PMID: 20301679.
  41. Rasgado LA, Reyes GC, Díaz FV. Modulation of brain glutamate dehydrogenase as a tool for controlling seizures. Acta Pharm. 2015 Dec;65(4):443-452.  https://doi.org/10.1515/acph-2015-0033
  42. Desguerre I, Hully M, Rio M, Nabbout R. Mitochondrial disorders and epilepsy. Rev Neurol (Paris). 2014 May;170(5):375-380.  https://doi.org/10.1016/j.neurol.2014.03.010.Epub2014May5
  43. Parikh S, Gupta A. Autonomic dysfunction in epilepsy and mitochondrial diseases. Semin Pediatr Neurol. 2013 Mar;20(1):31-34.  https://doi.org/10.1016/j.spen.2013.01.003
  44. Lopriore P, Gomes F, Montano V, Siciliano G, Mancuso M. Mitochondrial Epilepsy, a Challenge for Neurologists. Int J Mol Sci. 2022 Oct 30;23(21):13216. https://doi.org/10.3390/ijms232113216
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.