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Mamedov I.S.

GBU Scientific and Practical Center for Specialized assistance to children named after V.F. Voino-Yasenetsky DZM

Perevezentsev O.A.

GBU Scientific and Practical Center for Specialized assistance to children named after V.F. Voino-Yasenetsky DZM;
Rostov State Medical University of the Ministry of Health of the Russian Federation

Kulakova E.G.

GBU Scientific and Practical Center for Specialized assistance to children named after V.F. Voino-Yasenetsky DZM

Zolkina I.V.

Archimedes Clinic of New Medical Technologies LLC

Tkacheva M.I.

Archimedes Clinic of New Medical Technologies LLC

Paramonov S.A.

Archimedes Clinic of New Medical Technologies LLC

Simenel E.S.

Archimedes Clinic of New Medical Technologies LLC

Tatarinov P.A.

GBU Scientific and Practical Center for Specialized assistance to children named after V.F. Voino-Yasenetsky DZM;
Pirogov Russian National Research Medical University Ministry of HealthRF

Krapivkin A.I.

GBU Scientific and Practical Center for Specialized assistance to children named after V.F. Voino-Yasenetsky DZM

A personalized approach to the diagnosis of epilepsy in obese children

Authors:

Mamedov I.S., Perevezentsev O.A., Kulakova E.G., Zolkina I.V., Tkacheva M.I., Paramonov S.A., Simenel E.S., Tatarinov P.A., Krapivkin A.I.

More about the authors

Journal: Laboratory Service. 2025;14(1): 5‑12

DOI: 10.17116/labs2025140115

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Table of contents

A PERSONALIZED APPROACH TO THE DIAGNOSIS OF EPILEPSY IN OBESE CHILDREN
A PERSONALIZED APPROACH TO THE DIAGNOSIS OF EPILEPSY IN OBESE CHILDREN

To cite this article:

Mamedov IS, Perevezentsev OA, Kulakova EG, et al. . A personalized approach to the diagnosis of epilepsy in obese children. Laboratory Service. 2025;14(1):5‑12. (In Russ.)
https://doi.org/10.17116/labs2025140115

Подписка 2025-2 (Laboratory Service)
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INTRODUCTION

Epilepsy is one of the important problems of modern neurology. Various epileptic syndromes can be combined with other diseases, in particular, with obesity. Currently, various aspects of the etiopathogenesis of epileptic seizures against the background of obesity are actively studied.

THE AIM OF THE WORK

Is to develop an approach to personalized biochemical diagnostics of epilepsy in children based on potential changes in the profile of organic acids in urine.

MATERIALS AND METHODS

The study included 22 patients aged 1 to 16 years (mean age 11.7 years): 16 patients with various epileptic syndromes against the background of obesity and 6 patients in the comparison group. HPLC-MS. Results carried out the study of the profile of 60 organic acids in urine. In the group of patients with epilepsy against the background of obesity, excess of the upper reference limit of a number of markers of the Krebs cycle (fumaric and 2-ketoglutaric acids), bacterial dysbiosis and lactic acid were detected. Also in the patient sample, in contrast to the comparison group, an increase in the level of mitochondrial dysfunction markers was found.

RESULTS

In the group of patients with epilepsy against the background of obesity, the upper reference limit of a number of markers of the Krebs cycle (fumaric and 2-ketoglutaric acids), bacterial dysbiosis and lactic acid were exceeded. Also in the sample of patients, in contrast to the comparison group, an increase in the level of markers of mitochondrial dysfunction was found.

CONCLUSION

Thus, we identified changes in a number of metabolic markers associated with epilepsy in children against the background of obesity.

Keywords:

epilepsy
obesity
organic acids
HPLC/MS

Authors:

Mamedov I.S.

GBU Scientific and Practical Center for Specialized assistance to children named after V.F. Voino-Yasenetsky DZM

Perevezentsev O.A.

GBU Scientific and Practical Center for Specialized assistance to children named after V.F. Voino-Yasenetsky DZM;
Rostov State Medical University of the Ministry of Health of the Russian Federation

Kulakova E.G.

GBU Scientific and Practical Center for Specialized assistance to children named after V.F. Voino-Yasenetsky DZM

Zolkina I.V.

Archimedes Clinic of New Medical Technologies LLC

Tkacheva M.I.

Archimedes Clinic of New Medical Technologies LLC

Paramonov S.A.

Archimedes Clinic of New Medical Technologies LLC

Simenel E.S.

Archimedes Clinic of New Medical Technologies LLC

Tatarinov P.A.

GBU Scientific and Practical Center for Specialized assistance to children named after V.F. Voino-Yasenetsky DZM;
Pirogov Russian National Research Medical University Ministry of HealthRF

Krapivkin A.I.

GBU Scientific and Practical Center for Specialized assistance to children named after V.F. Voino-Yasenetsky DZM

Received:

16.12.2024

Accepted:

03.02.2025

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