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Burd S.G.

Federal Center of Brain and Neurotechnologies;
Pirogov Russian National Research Medical University

Bogolepova A.N.

Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency;
Pirogov Russian National Research Medical University

Lebedeva A.V.

Federal Center of Brain Research and Neurotechnologies;
Pirogov Russian National Research Medical University

Rubleva Yu.V.

Federal Center of Brain Research and Neurotechnologies

Kovalenko E.A.

Federal Center of Brain Research and Neurotechnologies;
Pirogov Russian National Research Medical University

Makhnovich E.V.

Federal Center for Brain and Neurotechnologies;
Pirogov Russian National Research Medical University

Osinovskaya N.A.

Federal Center of Brain Research and Neurotechnologies

Gileva E.A.

Federal Center for Brain and Neurotechnologies

Pantina N.V.

Federal Center of Brain Research and Neurotechnologies

Kovaleva I.I.

Federal Center of Brain Research and Neurotechnologies

Efimenko A.P.

Federal Center of Brain Research and Neurotechnologies

Bokitko T.A.

Federal Center of Brain and Neurotechnologies

Alekseeva G.A.

Federal Center of Brain Research and Neurotechnologies

Epileptic seizures in patients with Alzheimer’s disease

Authors:

Burd S.G., Bogolepova A.N., Lebedeva A.V., Rubleva Yu.V., Kovalenko E.A., Makhnovich E.V., Osinovskaya N.A., Gileva E.A., Pantina N.V., Kovaleva I.I., Efimenko A.P., Bokitko T.A., Alekseeva G.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(11): 36‑43

DOI: 10.17116/jnevro202512511136

Read: 1116 times

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Table of contents

EPILEPTIC SEIZURES IN PATIENTS WITH ALZHEIMER’S DISEASE
EPILEPTIC SEIZURES IN PATIENTS WITH ALZHEIMER’S DISEASE

To cite this article:

Burd SG, Bogolepova AN, Lebedeva AV, et al. Epileptic seizures in patients with Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(11):36‑43. (In Russ.)
https://doi.org/10.17116/jnevro202512511136

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Использование инфографики авторами научных работ
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Abstract:

Neurodegenerative diseases are one of the leading causes of epileptic seizures with onset in later life. Particular attention is paid to Alzheimer’s disease (AD), as a disease that accounts for up to 70% of cases of all types of dementia, and, according to the literature, shares genetic and pathophysiological mechanisms with epilepsy. This paper reviews the literature on the prevalence of epilepsy in AD patients. The reasons for the widely varying data (ranging from 0.5 to 64%) depending on the selected population, the reliability of the established diagnosis, the form and genetic characteristics of the disease, as well as the examination methods used, are considered. The main risk factors for the development of AD and epilepsy, semiotics and features of seizures in patients with AD, as well as approaches to the treatment of such patients, are also covered.

Keywords:

epilepsy
neurodegenerative disease
Alzheimer’s disease
epileptic seizures
antiepileptic drugs
beta-amyloid
tau protein

Authors:

Burd S.G.

Federal Center of Brain and Neurotechnologies;
Pirogov Russian National Research Medical University

Bogolepova A.N.

Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency;
Pirogov Russian National Research Medical University

Lebedeva A.V.

Federal Center of Brain Research and Neurotechnologies;
Pirogov Russian National Research Medical University

Rubleva Yu.V.

Federal Center of Brain Research and Neurotechnologies

Kovalenko E.A.

Federal Center of Brain Research and Neurotechnologies;
Pirogov Russian National Research Medical University

Makhnovich E.V.

Federal Center for Brain and Neurotechnologies;
Pirogov Russian National Research Medical University

Osinovskaya N.A.

Federal Center of Brain Research and Neurotechnologies

Gileva E.A.

Federal Center for Brain and Neurotechnologies

Pantina N.V.

Federal Center of Brain Research and Neurotechnologies

Kovaleva I.I.

Federal Center of Brain Research and Neurotechnologies

Efimenko A.P.

Federal Center of Brain Research and Neurotechnologies

Bokitko T.A.

Federal Center of Brain and Neurotechnologies

Alekseeva G.A.

Federal Center of Brain Research and Neurotechnologies

Received:

06.05.2025

Accepted:

14.05.2025

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