Herpesviruses and biomarkers in disseminated encephalomyelitis and multiple sclerosis in children

Skripchenko E.Yu.; Zheleznikova G.F.; Alekseeva L.A.; Skripchenko N.V.; Astapova A.V.; Gorelik Е.Yu.; Vilnits A.A.

doi:https://doi.org/10.17116/jnevro2021121031138

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Abstract:

The relevance of the study of demyelinating diseases is due to their increasing frequency in children, clarification of the role of infectious agents in their genesis, as well as the possibility of transformation of disseminated encephalomyelitis into multiple sclerosis. The literature review presents the currently available information on the causes of the development of demyelinating diseases, biomarkers of disseminated encephalomyelitis and multiple sclerosis, the causes of an unfavorable course and possible laboratory parameters indicating the transition from one disease to another, which can be used as prognostic factors. The authors also noted the experience of the authors on the importance of adequate etiopathogenetic therapy in changing the nature of the course of the disease, in particular, when confirming the relationship between the frequency of exacerbations of ADEM and MS with the activation of herpesvirus infections, courses of specific antiviral therapy are effective, as well as pathogenetic therapy aimed at correcting endothelial dysfunction using the drug cytoflavin.

Keywords:

herpes viruses

children

multiple sclerosis

disseminated encephalomyelitis

demyelination

cytoflavin

prognosis

Authors:

Skripchenko E.Yu.

Pediatric Research and Clinical Center for Infectious Diseases;
Saint-Petersburg State Pediatric Medical University

Zheleznikova G.F.

Pediatric Research and Clinical Center for Infectious Diseases

Alekseeva L.A.

Pediatric Research and Clinical Center for Infectious Diseases

Skripchenko N.V.

Children’s Research and Clinical Center for Infectious Diseases;
St. Petersburg State Pediatric Medical University

Astapova A.V.

Pediatric Research and Clinical Center for Infectious Diseases

Gorelik Е.Yu.

Pediatric Research and Clinical Center for Infectious Diseases

Vilnits A.A.

Pediatric Research and Clinical Center for Infectious Diseases;
St. Petersburg State Pediatric Medical University

Received:

27.01.2021

Accepted:

08.02.2021

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References:

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