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Myakoshina E.B.

Helmholtz National Medical Research Center of Eye Diseases;
Russian University of Medicine

Saakyan S.V.

Helmholtz National Medical Research Center of Eye Diseases;
Russian University of Medicine (ROSUNIMED)

Balatskaya N.V.

Helmholtz National Medical Research Center of Eye Diseases

Krichevskaya G.I.

Helmholtz National Medical Research Center of Eye Diseases

Svetlova E.V.

Helmholtz National Medical Research Center of Eye Diseases

Svirina I.V.

Helmholtz National Medical Research Center of Eye Diseases

Iris melanoma: correlation of clinical, morphometric, pathomorphological features and infectious status

Authors:

Myakoshina E.B., Saakyan S.V., Balatskaya N.V., Krichevskaya G.I., Svetlova E.V., Svirina I.V.

More about the authors

Journal: Russian Annals of Ophthalmology. 2025;141(1): 13‑20

DOI: 10.17116/oftalma202514101113

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Table of contents

IRIS MELANOMA: CORRELATION OF CLINICAL, MORPHOMETRIC, PATHOMORPHOLOGICAL FEATURES AND INFECTIOUS STATUS
IRIS MELANOMA: CORRELATION OF CLINICAL, MORPHOMETRIC, PATHOMORPHOLOGICAL FEATURES AND INFECTIOUS STATUS

To cite this article:

Myakoshina EB, Saakyan SV, Balatskaya NV, Krichevskaya GI, Svetlova EV, Svirina IV. Iris melanoma: correlation of clinical, morphometric, pathomorphological features and infectious status. Russian Annals of Ophthalmology. 2025;141(1):13‑20. (In Russ.)
https://doi.org/10.17116/oftalma202514101113

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Iris melanoma is a rare malignant tumor of melanocytic origin. Oncogenic viruses, whose invasion of the cell alters proliferation regulation mechanisms, play an important role in tumor development and progression.

PURPOSE

To identify clinical, morphometric, and pathomorphological correlations with infectious status in patients with iris melanoma and to determine predictors of unfavorable prognosis.

MATERIAL AND METHODS

Sixteen patients with iris melanoma were examined. Anterior segment optical coherence tomography (AS-OCT) was performed using the RS-3000 Advance system (Nidek, Japan) with OCT-Angiography software. The specific humoral response to herpesviruses was assessed by detecting IgG and IgM antibodies in blood serum via enzyme-linked immunosorbent assay (ELISA) using an automated immunoassay analyzer LAZURITE (Dynex Technologies Inc., USA). Statistical analysis employed Spearman’s rank correlation coefficient (rs).

RESULTS

Iris melanoma was predominantly observed in female patients (n=11) of advanced age (n=8). Biomicroscopy revealed 10 pigmented, 1 hypopigmented, and 5 non-pigmented tumors. The mean prominence on OCT was 1461.7±740.5 μm, the basal diameter was 3409.6±1822.8 μm, and the volume was 4.7±3.7 mm3. Ciliary body involvement was detected in 10 patients. Iris melanomas were classified as epithelioid-cell (n=1), spindle-cell (n=12), and mixed-cell (n=3) types. Extrabulbar growth was noted in three patients. Serological markers of viral reactivation were identified: herpes simplex virus type 1 (n=11) and type 2 (n=5), and cytomegalovirus (n=3).

Direct correlations (rs=0.5—0.8) were identified between the presence of serological markers of herpesvirus reactivation and unfavorable prognostic features, including advanced age, maximum tumor basal diameter, ciliary body involvement, dense pigmentation, and extrabulbar growth. The mean follow-up period was 18.5±2.97 months, and all patients were alive, with no evidence of recurrence.

CONCLUSION

The findings of this study demonstrated a correlation between herpesvirus reactivation and unfavorable prognostic features of iris melanoma. Further research is needed to deepen the understanding of the role of herpesviruses in the pathogenesis of iris melanoma and to develop personalized approaches to prevention and treatment.

Keywords:

iris melanoma
anterior segment optical coherence tomography
herpesviruses

Authors:

Myakoshina E.B.

Helmholtz National Medical Research Center of Eye Diseases;
Russian University of Medicine

Saakyan S.V.

Helmholtz National Medical Research Center of Eye Diseases;
Russian University of Medicine (ROSUNIMED)

Balatskaya N.V.

Helmholtz National Medical Research Center of Eye Diseases

Krichevskaya G.I.

Helmholtz National Medical Research Center of Eye Diseases

Svetlova E.V.

Helmholtz National Medical Research Center of Eye Diseases

Svirina I.V.

Helmholtz National Medical Research Center of Eye Diseases

Received:

11.01.2024

Accepted:

14.04.2024

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