The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Rukavishnikov G.V.

Bekhterev National Medical Research Center for Psychiatry and Neurology

Neznanov N.G.

Bekhterev National Medical Research Center for Psychiatry and Neurology;
Pavlov First Saint-Petersburg State Medical University

Mazo G.E.

Bekhterev National Medical Research Center for Psychiatry and Neurology

Microbiota and autoimmune processes as potential therapeutic targets in comorbid depression and inflammatory bowel disease

Authors:

Rukavishnikov G.V., Neznanov N.G., Mazo G.E.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(12): 134‑138

DOI: 10.17116/jnevro2021121121134

Read: 3573 times

Download PDF (RU)
Contact the author
Table of contents

MICROBIOTA AND AUTOIMMUNE PROCESSES AS POTENTIAL THERAPEUTIC TARGETS IN COMORBID DEPRESSION AND INFLAMMATORY BOWEL DISEASE
MICROBIOTA AND AUTOIMMUNE PROCESSES AS POTENTIAL THERAPEUTIC TARGETS IN COMORBID DEPRESSION AND INFLAMMATORY BOWEL DISEASE

To cite this article:

Rukavishnikov GV, Neznanov NG, Mazo GE. Microbiota and autoimmune processes as potential therapeutic targets in comorbid depression and inflammatory bowel disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(12):134‑138. (In Russ.)
https://doi.org/10.17116/jnevro2021121121134

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
The state of mental health of migrant workers and citi­zens of the Russian Fede­ration: A comparative analysis as illu­strated by the Moscow region. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4):95-101
Factors of depression acco­rding to acti­graphy in the fall season. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5-2):27-32
Identification of depression biomarkers: Prospects for use in clinical practice. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5):51-55
Depression Anxiety Stress Scale (russian language version). S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5):103-107
Inve­stigation of the rela­tionship of indi­vidual characteristics of the brain bioelectrical acti­vity with levels of mental stress, aggression, anxiety, and depression. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5):108-117
Epidemiology of M. geni­talium infe­ction. What is known?. Russian Journal of Clinical Dermatology and Vene­reology. 2025;(2):143-152
Influence of griseofulvin on inte­stinal microbiota in the treatment of microsporia in rural children. Russian Journal of Clinical Dermatology and Vene­reology. 2025;(2):185-190
Pathogenesis of fibrosis deve­lopment in ovarian endo­metriosis. Russian Journal of Archive of Pathology. 2025;(2):73-78
Obesity in the context of the «old friends» hypo­thesis. Russian Journal of Preventive Medi­cine. 2025;(4):136-141
Portopulmonary hype­rtension. Journal of Respiratory Medi­cine. 2025;(2):39-44
Abstract:

The aim of this review is to evaluate current information on the shared pathologic mechanisms of inflammatory bowel disease (IBD) and depression, with an emphasis on inflammatory mechanisms and the role of the gut microbiota. According to the recent data, abovementioned elements play an important role in the risks of depression and anxiety in IBD. The impact on inflammatory processes and microbiota can be used to develop new therapeutic approaches both in cases of comorbid and isolated mental pathology. Despite this, the number of high-quality clinical studies in this area is currently extremely small. Further research into colitis-associated inflammation and dysbiosis may be the key to further understanding and creating optimal treatment of comorbid diseases.

Keywords:

depression
Chron’s disease
ulcerative colitis
biological comorbidity
microbiota
autoimmune disease
pathology

Authors:

Rukavishnikov G.V.

Bekhterev National Medical Research Center for Psychiatry and Neurology

Neznanov N.G.

Bekhterev National Medical Research Center for Psychiatry and Neurology;
Pavlov First Saint-Petersburg State Medical University

Mazo G.E.

Bekhterev National Medical Research Center for Psychiatry and Neurology

Received:

06.07.2021

Accepted:

06.09.2021

Close metadata

References:

  1. Moulton CD, Pavlidis P, Norton C, et al. Depressive symptoms in inflammatory bowel disease: an extraintestinal manifestation of inflammation? Clin Exp Immunol. 2019;197(3):308-318.  https://doi.org/10.1111/cei.13276
  2. Mittermaier C, Dejaco C, Waldhoer T, et al. Impact of Depressive Mood on Relapse in Patients with Inflammatory Bowel Disease: A Prospective 18-Month Follow-up Study. Psychosomatic Medicine. 2004;66(1):79-84.  https://doi.org/10.1097/01.psy.0000106907.24881.f2
  3. WHO, Depression, 30 January 2020. Accessed 28 June 2021. https://www.who.int/news-room/fact-sheets/detail/depression
  4. Walker EA, Gelfand MD, Gelfand AN, et al. The Relationship of Current Psychiatric Disorder to Functional Disability and Distress in Patients with Inflammatory Bowel Disease. General Hospital Psychiatry. 1996;18(4):220-229.  https://doi.org/10.1016/0163-8343(96)00036-9
  5. Neznanov NG, Mazo GE, Kibitov AO, eds. Depression and somatic disorders risks. M.: Medical Book; 2018. (In Russ.).
  6. Rukavishnikov GV, Kibitov AO, Mazo GE, Neznanov NG. Genetic comorbidity of depression and somatic disorders. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2019;119(1):89-96. (In Russ.). https://doi.org/10.17116/jnevro201911901189
  7. Neznanov NG, Leonova LV, Rukavishnikov GV, et al. Enteric microbiota as a research object in mental disorders. Uspehi Fiziologicheskih Nauk. 2021;52(1):64-76. (In Russ.). https://doi.org/10.31857/S0301179821010069
  8. Iglesias M, Barreiro de Acosta M, Vázquez I, et al. Psychological Impact of Crohn’s Disease on Patients in Remission: Anxiety and Depression Risks. Revista Espanola de Enfermedades Digestiva. 2009;101(4):249-257.  https://pubmed.ncbi.nlm.nih.gov/19492900/
  9. Martin-Subero M, Anderson G, Kanchanatawan B, et al. Comorbidity between depression and inflammatory bowel disease explained by immune-inflammatory, oxidative, and nitrosative stress; tryptophan catabolite; and gut-brain pathways. CNS Spectr. 2016;21(2):184-198.  https://doi.org/10.1017/S1092852915000449
  10. Neuendorf R, Harding A, Stello N, et al. Depression and Anxiety in Patients with Inflammatory Bowel Disease: A Systematic Review. Journal of Psychosomatic Research. 2016;87:70-80.  https://doi.org/10.1016/j.jpsychores.2016.06.001
  11. Kurina LM, Goldacre MJ, Yeates D, Gill LE. Depression and Anxiety in People with Inflammatory Bowel Disease. Journal of Epidemiology and Community Health. 2001;55(10):716-720.  https://doi.org/10.1136/jech.55.10.716
  12. Bonaz BL, Bernstein CN. Brain-gut interactions in inflammatory bowel disease. Gastroenterology. 2013;144(1):36-49.  https://doi.org/10.1053/j.gastro.2012.10.003
  13. Ulrich-Lai YM, Herman JP. Neural regulation of endocrine and autonomic stress responses. Nat Rev Neurosci. 2009;10:397-409.  https://doi.org/10.1038/nrn2647
  14. Kelly JR, Kennedy PJ, Cryan JF, et al. Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders. Front Cell Neurosci. 2015;9:392.  https://doi.org/10.3389/fncel.2015.00392
  15. Atarashi K, Tanoue T, Oshima K, et al. Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature. 2013;500:232-236.  https://doi.org/10.1038/nature12331
  16. Chu H, Khosravi A, Kusumawardhani IP, et al. Gene — microbiota interactions contribute to the pathogenesis of inflammatory bowel disease. Science. 2016;352:1116-1120. https://doi.org/10.1126/science.aad9948
  17. Goehler LE, Gaykema RP, Opitz N, et al. Activation in vagal afferents and central autonomic pathways: early responses to intestinal infection with Campylobacter jejuni. Brain Behav Immun. 2005;19:334-344.  https://doi.org/10.1016/j.bbi.2004.09.002
  18. Sudo N, Chida Y, Aiba Y, et al. Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice. J Physiol. 2004;558:263-275.  https://doi.org/10.1113/jphysiol.2004.063388
  19. Ait-Belgnaoui A, Durand H, Cartier C, et al. Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats. Psychoneuroendocrinology. 2012;37:1885-1895. https://doi.org/10.1016/j.psyneuen.2012.03.024
  20. Bercik P, Denou E, Collins J, et al. The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice. Gastroenterology. 2011;141:599-609.  https://doi.org/10.1053/j.gastro.2011.04.052
  21. Frolkis AD, Vallerand IA, Shaheen AA, et al. Depression increases the risk of inflammatory bowel disease, which may be mitigated by the use of antidepressants in the treatment of depression. Gut, Gutjnl. 2018;317182. https://doi.org/10.1136/gutjnl-2018-317182
  22. Macer BJ, Prady SL, Mikocka-Walus A. Antidepressants in Inflammatory Bowel Disease: A Systematic Review. Inflamm Bowel Dis. 2017;23(4):534-550.  https://doi.org/10.1097/MIB.0000000000001059
  23. Mikocka-Walus A, Hughes PA, Bampton P, et al. Fluoxetine for maintenance of remission and to improve quality of life in patients with Crohn’s disease: a pilot randomized placebo-controlled trial. J Crohns Colitis. 2017;11:509-514.  https://doi.org/10.1093/ecco-jcc/jjw165
  24. Raison CL, Rutherford RE, Woolwine BJ, et al. A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers. JAMA Psychiatry. 2013;70:31-41.  https://doi.org/10.1001/2013.jamapsychiatry.4
  25. Horst S, Chao A, Rosen M et al. Treatment with immunosuppressive therapy may improve depressive symptoms in patients with inflammatory bowel disease. Dig Dis Sci. 2015;60:465-470.  https://doi.org/10.1007/s10620-014-3375-0
  26. Stevens BW, Borren NZ, Velonias G, et al. Therapy is associated with an improvement in sleep quality and mood in inflammatory bowel diseases. Dig Dis Sci. 2017;62:197-206.  https://doi.org/10.1007/s10620-016-4356-2
  27. Gracie DJ, Hamlin PJ, Ford AC. The influence of the brain-gut axis in inflammatory bowel disease and possible implications for treatment. Lancet Gastroenterol Hepatol. 2019;4(8):632-642.  https://doi.org/10.1016/S2468-1253(19)30089-5
  28. Guida F, Turco F, Iannotta M, et al. Antibiotic-induced microbiota perturbation causes gut endocannabinoidome changes, hippocampal neuroglial reorganization and depression in mice. Brain, Behavior, and Immunity. 2018;67:230-245.  https://doi.org/10.1016/j.bbi.2017.09.001
  29. Ait-Belgnaoui A, Durand H, Cartier C, et al. Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats. Psychoneuroendocrinology. 2012;37(11):1885-1895. https://doi.org/10.1016/j.psyneuen.2012.03.024
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.