Acute disseminated encephalomyelitis

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Acute disseminated encephalomyelitis (AEM) is an immune-mediated inflammatory demyelinating disease of the central nervous system (CNS), usually single-phase. In WREM, multiple lesions of the central nervous system of an inflammatory-demyelinating nature accompanied by extremely polymorphic neurological disorders develop acutely or subacutely. The review considers the issues of epidemiology, trigger factors of the inflammatory process, clinical manifestations, differential and molecular diagnostics of WECM, and outlines the ways for further study of this pathology.

Keywords:

acute disseminated encephalomyelitis

multiple sclerosis

demyelination

levamisole

Authors:

Averchenkov D.M.

Buyanov City Clinical Hospital

Volik A.V.

Lomonosov Moscow State University

Fominykh V.V.

Buyanov City Clinical Hospital;
Institute of Higher Nervous Activity and Neurophysiology

Nazarov V.D.

Pavlov First St. Petersburg State Medical University

Moshnikova A.N.

Scientific Methodological Center of the Ministry of Health of Russia for Molecular Medicine;
Pavlov First St. Petersburg State Medical University

Lapin S.V.

St. Petersburg Center for Multiple Sclerosis and Other Autoimmune Diseases of City Clinical Hospital No. 31

ORCID: 0000-0002-4998-3699

Brylev L.V.

Buyanov City Clinical Hospital;
Institute of Higher Nervous Activity and Neurophysiology;
Solovyov Scientific and Practical Psychoneurological Center

SPIN RSCI: 9749-8920
Scopus AuthorID: 23110301900
ORCID: 0000-0003-2314-6523

Guekht A.B.

Buyanov City Clinical Hospital;
Solovyov Scientific and Practical Psychoneurological Center;
Pirogov Russian National Research Medical University

SPIN RSCI: 7691-3288
Scopus AuthorID: 7003326363
ResearcherID: Y-6725-2018
ORCID: 0000-0002-1170-6127

Received:

12.08.2021

Accepted:

27.09.2021

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