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Esin R.G.

Kazan State Medical Academy — Branch of the Russian Medical Academy of Continuing Professional Education;
Kazan (Volga Region) Federal University

Esin O.R.

Kazan (Volga region) Federal University;
Clinic of Otorhinolaryngology

Khakimova A.R.

Kazan State Medical Academy

Stress-induced disorders

Authors:

Esin R.G., Esin O.R., Khakimova A.R.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(5): 131‑137

DOI: 10.17116/jnevro2020120051131

Read: 16232 times

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Table of contents

STRESS-INDUCED DISORDERS
STRESS-INDUCED DISORDERS

To cite this article:

Esin RG, Esin OR, Khakimova AR. Stress-induced disorders. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(5):131‑137. (In Russ.)
https://doi.org/10.17116/jnevro2020120051131

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The review analyses the diseases and conditions caused by acute and chronic stress. The authors describe the pathogenesis of stress-induced disorders from the perspective of imbalance between stress-realizing and stress-limiting systems (sympathetic and parasympathetic nervous systems). The effects of acute and chronic stress on the cardiovascular, respiratory, and immune systems, the contribution of stress to the pathogenesis of skin diseases, the gastrointestinal tract, post-stroke disorders, headaches, and dizziness are considered. The authors highlight the role of gamma-aminobutyric acid (GABA) as the main mediator of stress-limiting systems in protecting the nervous system and target organs from the damaging effects of acute and chronic stress. The authors recommend aminophenylbutyric acid hydrochloride, an analogue of GABA, as a drug with protective effect on organs and systems that are exposed to the negative effects of acute and chronic stress. Aminophenylbutyric acid hydrochloride (anvifen) is successfully used in both adults and children, has good tolerance, has no significant drug interactions and side-effects.

Keywords:

stress
stressors
aminophenylbutyric acid hydrochloride
anvifen

Authors:

Esin R.G.

Kazan State Medical Academy — Branch of the Russian Medical Academy of Continuing Professional Education;
Kazan (Volga Region) Federal University

Esin O.R.

Kazan (Volga region) Federal University;
Clinic of Otorhinolaryngology

Khakimova A.R.

Kazan State Medical Academy

Received:

24.03.2020

Accepted:

24.03.2020

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References:

  1. Pshennikova MG. Stress: regulatory systems and resistance to stress damage. In: Kryzhanovskij GN. ed. Dizreguljacionnaja patologija: Rukovodstvo dlja vrachej i biologov. M.: Medicina, 2002;307-328. (In Russ.).
  2. Khananashvili MM. Biologically positive and negative psychogenic (informational) stress. In: Kryzhanovskij GN. ed. Dizreguljacionnaja patologija: Rukovodstvo dlja vrachej i biologov. M.: Medicina: 2002;294-306. (In Russ.).
  3. Chrousos GP. Stress and disorders of the stress system. Nat Rev Endocrinol. 2009;5(7):374-381.  https://doi.org/10.1038/nrendo.2009.106
  4. Koolhaas JM, Bartolomucci A, Buwalda B, de Boer SF, Flugge G, Korte SM, Meerlo P, Murison R, Olivier B, Palanza P, Richter-Levin G, Sgoifo A, Steimer T, Stiedl O, van Dijk G, Wöhr M, Fuchs E. Stress revisited: a critical evaluation of the stress concept. Neurosci Biobehav Rev. 2011;35(5):1291-1301. https://doi.org/10.1016/j.neubiorev.2011.02.003
  5. Kloet ER, Joëls M, Holsboer F. Stress and the brain: from adaptation to disease. Nat Rev Neurosci. 2005;6(6):463-475.  https://doi.org/10.1038/nrn1683
  6. Guan L, Collet JP, Mazowita G, Claydon VE. Autonomic Nervous System and Stress to Predict Secondary Ischemic Events after Transient Ischemic Attack or Minor Stroke: Possible Implications of Heart Rate Variability. Front. Neurol. 2018;9: 45-49.  https://doi.org/10.3389/fneur.2018.00090
  7. Burton CAC, Murray J, Holmes J, Astin F, Greenwood D, Knapp P. Frequency of Anxiety after Stroke: A Systematic Review and Meta-Analysis of Observational Studies. International Journal of Stroke. 2013;8(7):545-559.  https://doi.org/10.1111/j.1747-4949.2012.00906.x
  8. Chun H-YY, Whiteley WN, Dennis MS, Mead GE, Carson AJ. Anxiety After Stroke. Stroke. 2018;49(3):556-564.  https://doi.org/10.1161/strokeaha.117.020078
  9. Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation as an independent risk factor for stroke: the Framingham study. Stroke. 1991;22:983-988.  https://doi.org/10.1161/01.str.22.8.983
  10. Shen MJ, Choi E-K, Tan AY, Lin S-F, Fishbein MC, Chen LS, Chen PS. Neural mechanisms of atrial arrhythmias. Nat Rev Cardiol. 2012;9(1):30-39.  https://doi.org/10.1038/nrcardio.2011.139
  11. Fuster V, Rydén LE, Cannom DS, Crijns HJ, Curtis AB, Ellenbogen KA, Halperin JL, Kay GN, Le Huezey J-Y, Lowe JE, Olsson SB, Prystowsky EN, Tamargo JL, Wann LS. 2011 ACCF/AHA/HRS focused updates incorporated into the ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation. Circulation. 2011;123(10):e269-e367. https://doi.org/10.1161/CIR.0b013e318214876d
  12. Marigold JRG, Arias M, Vassallo M, Allen SC, Kwan JS. Autonomic dysfunction in older people. Rev Clin Gerontol. 2010;21(1):28-44.  https://doi.org/10.1017/s0959259810000286
  13. Stein PK, Barzilay JI, Chaves PHM, Domitrovich PP, Gottdiener JS. Heart rate variability and its changes over 5 years in older adults. Age Ageing. 2009;38(2):212-218.  https://doi.org/10.1093/ageing/afn292
  14. Rasmussen MK, Mestre H, Nedergaard M. The glymphatic pathway in neurological disorders. Lancet Neurol. 2018;17(11):1016-1024. https://doi.org/10.1016/s1474-4422(18)30318-1
  15. Kernan WN, Ovbiagele B, Black HR, Bravata DM, Chimowitz MI, Ezekowitz MD, Fang MC, Fisher M, Furie KL, Heck DV, Johnston C, Kasner SE, Kittner SJ, Mitchell PH, Rich MW, Richardson DJ, Schwamm LH, Wilson JA, on behalf of the American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and Council on Peripheral Vascular Disease. Guidelines for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack. A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2014;45(7):2160-2236. https://doi.org/10.1161/STR.0000000000000024
  16. Wiysonge CS, Bradley HA, Volmink J, Mayosi BM, Opie LH. Beta-blockers for hypertension. Cochrane Database Syst Rev. 2012;8:1-77.  https://doi.org/10.1002/14651858.cd002003.pub4
  17. Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes. J Clin Invest. 2005;115(5):1111-1119. https://doi.org/10.1172/jci25102
  18. Schlaich M, Straznicky N, Lambert E, Lambert G. Metabolic syndrome: a sympathetic disease? Lancet Diabetes Endocrinol. 2015;3(2):148-158.  https://doi.org/10.1016/s2213-8587(14)70033-6
  19. Tarvainen MP, Laitinen TP, Lipponen JA, Cornforth DJ, Jelinek HF. Cardiac autonomic dysfunction in type 2 diabetes — effect of hyperglycemia and disease duration. Front Endocrinol. 2014;5(AUG):1-9.  https://doi.org/10.3389/fendo.2014.00130
  20. Christensen J, Toft E, Christensen M, Schmidt E. Heart rate variability and plasma lipids in men with and without ischaemic heart disease. Atherosclerosis. 1999;145:181-186.  https://doi.org/10.1016/s0021-9150(99)00052-0
  21. Kataoka Y, Niwa M, Yamashita K, Taniyama K. GABA receptor function in the parasympathetic ganglia. Jpn J Physiol. 1994;44(Suppl 2):S125-129. PubMed PMID: 7752515 
  22. Black PH. The inflammatory response is an integral part of the stress response: implications for atherosclerosis, insulin resistance, type II diabetes and metabolic syndrome X. Brain Behav Immun. 2003;17(5):350-364.  https://doi.org/10.1016/s0889-1591(03)00048-5
  23. Von Känel R. Acute mental stress and hemostasis: When physiology becomes vascular harm. Thrombosis Research. 2015;135:S52-S55.  https://doi.org/10.1016/s0049-3848(15)50444-1
  24. Austin A, Wissmann T, von Kanel R. Stress and Hemostasis: An Update. Seminars in Thrombosis and Hemostasis. 2013;39(08):902-912.  https://doi.org/10.1055/s-0033-1357487
  25. Mayer EA. The neurobiology of stress and gastrointestinal disease. Gut. 2000;47:861-869.  https://doi.org/10.1136/gut.47.6.861
  26. Mizyed I, Fass SS, Fass R. Review article: gastro-oesophageal reflux disease and psychological comorbidity. Aliment Pharmacol Ther. 2009;29(4):351-358.  https://doi.org/10.1111/j.1365-2036.2008.03883.x
  27. Singh S, Graff LA, Bernstein CN. Do NSAIDs, Antibiotics, Infections, or Stress Trigger Flares in IBD? Am J Gastroenterol. 2009;104(5):129.  https://doi.org/10.1038/ajg.2009.15
  28. Bailey MT, Dowd SE, Galley JD, Hufnagle AR, Allen RG, Lyte M. Exposure to a social stressor alters the structure of the intestinal microbiota: Implications for stressor-induced immunomodulation. Brai Behavior Immun. 2011;25(3):397-407.  https://doi.org/10.1016/j.bbi.2010.10.023
  29. Khan S, Chang L. Diagnosis and management of IBS. Nat Rev Gastroenterol Hepatol. 2010;7(10):565-581.  https://doi.org/10.1038/nrgastro.2010.137
  30. Dhabhar FS. Enhancing versus Suppressive Effects of Stress on Immune Function: Implications for Immunoprotection versus Immunopathology. All Asth Clin Immun. 2008;4(1):2.  https://doi.org/10.1186/1710-1492-4-1-2
  31. Parker J, Klein SL, Mc Clintock MK, Morison WL, Ye X, Conti CJ, Peterson N, Nousari CH, Tausk FA. Chronic stress accelerates ultraviolet-induced cutaneous carcinogenesis. J Am Acad Dermatol. 2004;51(6):919-922.  https://doi.org/10.1016/j.jaad.2004.08.042
  32. Verhoeven EW, Kraaimaat FW, Jong EM, Schalkwijk J, van de Kerkhof PC, Evers AWM. Effect of daily stressors on psoriasis: a prospective study. J. Invest. Dermatol. 2009;129(8):2075-2077. https://doi.org/10.1038/jid.2008.460
  33. Chiu A, Chon SY, Kimball AB. The response of skin disease to stress: Changes in the Severity of Acne Vulgaris as Affected by Examination Stress. Arch Dermatol. 2003;139(7):897-900.  https://doi.org/10.1001/archderm.139.7.897
  34. Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, Morrow JD, Cawthon RM. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci U.S.A. 2004;101(49):17312-17315. https://doi.org/10.1073/pnas.0407162101
  35. Oh SH, Bae BG, Park CO, Noh JY, Park IH, Wu WH, Lee KH. Association of Stress with Symptoms of Atopic Dermatitis. Acta Derm Venereol. 2010;90(6):582-588.  https://doi.org/10.2340/00015555-0933
  36. Manni M, Maestroni GJM. Sympathetic nervous modulation of the skin innate and adaptive immune response to peptidoglycan but not lipopolysaccharide: Involvement of β-adrenoceptors and relevance in inflammatory diseases. Brain Behav Immun. 2008;22(1):80-88.  https://doi.org/10.1016/j.bbi.2007.06.016
  37. Horner CC, Dula C, Bacharier LB, Garbutt JM, Gonzalez C, Deych E, Shannon WD, Strunk RC. Daily global stress is associated with nocturnal asthma awakenings in school-age children. J Allergy Clin Immunol. 2016;138(4):1196-1199.e3.  https://doi.org/10.1016/j.jaci.2016.01.054
  38. Bloomberg GR, Chen E. The relationship of psychologic stress with childhood asthma. Immunol Allergy Clin of North Am. 2005;25(1):83-105.  https://doi.org/10.1016/j.iac.2004.09.001
  39. Ritz T, Simon E, Trueba AF. Stress-Induced Respiratory Pattern Changes in Asthma. Psychosom Med. 2011;73(6):514-521.  https://doi.org/10.1097/psy.0b013e318222050d
  40. Niggemann B. Rostrum: How to diagnose psychogenic and functional breathing disorders in children and adolescents. Pediatr Allergy Immunol. 2010;21(6):895-899.  https://doi.org/10.1111/j.1399-3038.2010.01060.x
  41. Wehry AM, Beesdo-Baum K, Hennelly MM, Connolly SD, Strawn JR. Assessment and treatment of anxiety disorders in children and adolescents. Curr Psychiatry Rep. 2015;17(7):52.  https://doi.org/10.1007/s11920-015-0591-z
  42. Esin OR. The epidemiology of chronic pain in children and adolescents. Zh Nevrol Psikhiatr Im SS Korsakova. 2018;118(5):20-24. (In Russ.). https://doi.org/10.17116/jnevro20181185220
  43. Ngo DH, Vo TS. An Updated Review on Pharmaceutical Properties of Gamma-Aminobutyric Acid. Molecules. 2019;24(15):E2678. https://doi.org/10.3390/molecules24152678
  44. Lapin I. Phenibut (beta-phenyl-GABA): a tranquilizer and nootropic drug. CNS Drug Rev. 2001;7(4):471-481.  https://doi.org/10.1111/j.1527-3458.2001.tb00211.x
  45. Instructions for medical use of the drug Anvifen. (In Russ.). https://grls.rosminzdrav.ru/Grls_View_v2.aspx?routingGuid=ca6ba9df-69d1-4e26-8f0c-8e3b46204822&t=
  46. Lukushkina EF, Karpovich EI, Chaban OD. Amino-phenylbutyric acid (Anvifen): clinical and pharmacological aspects and experience in pediatric neurology. Russkij medicinskij zhurnal. 2014;1:1-4. (In Russ.).
  47. Zykov VP, Komarova IB. The possibility of using aminophenylbutyric acid in the practice of a pediatric neurologist. Russkij medicinskij zhurnal. 2013;24:1166-1168. (In Russ.).
  48. Esin RG, Esin OR, Shamsutdinova RF. Modern approaches to the correction of maladaptive (psycho-vegetative) disorders in children and adolescents with tension headaches. Pediatrija. Zhurnal im. G.N. Speranskogo. 2015;94(1):106-112. (In Russ.).
  49. Esin OR. Treatment of Tension-Type Headaches in Adolescents (14–15 Years Old): the Efficacy of Aminophenylbutyric Acid Hydrochloride. Bio Nano Science. 2018;8(1):418-422.  https://doi.org/10.1007/s12668-018-0507-6
  50. Esin OR, Khairullin IK, Esin RG, Tokareva NV. Tension type headache: GABA-ergic drug anvifen efficacy. Zh Nevrol Psikhiatr Im SS Korsakova. 2016;116(2):58-61. (In Russ.). https://doi.org/10.17116/jnevro20161162158-61
  51. Strupp M, Brandt T. Diagnosis and treatment of vertigo and dizziness. Dtsch Arztebl Int. 2008;105(10):173-180.  https://doi.org/10.3238/arztebl.2008.0173
  52. Esin RG, Khairullin IK, Mukhametova ER, Esin OR. Persistent postural-perceptual dizziness. Zh Nevrol Psikhiatr Im SS Korsakova. 2017;117(4):28-33. (In Russ.). https://doi.org/10.17116/jnevro20171174128-33
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