Генетические варианты, ассоциированные с развитием стрессовых расстройств по данным GWAS

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Изучение генетических основ посттравматического стрессового расстройства (ПТСР) может быть полезно для прогнозирования риска его развития у человека, пережившего сильный травматический стресс, и способствовать более раннему выявлению проблемы и обращению к специалисту. Целью работы был обзор всех исследований GWAS, касающихся ПТСР. Всего включено 20 исследований, из них 5 метаанализов, 9 проведены на ветеранах войн. Рассмотрены функции генов и их ассоциации, которые включали в себя однуклеотидные полиморфизмы в разных группах генов, участвующих в эмбриогенезе, формировании нейронов, функционировании клетки, а также множество последовательностей ДНК, на которых транскрибируется некодирующая РНК. Изучена повторяемость полученных результатов между исследованиями и на репликативных выборках. Между исследованиями ассоциации повторились в генах CAMKV, CDHR4, DCC, FAM120A, FOXP2 (3 работы), MAD1L1 (3 работы), MAPT, NCAM1, NOS1, SP4, ZMYM4, TCF4. Отдельно рассмотрено новое и масштабное исследование с множеством обнаруженных ассоциаций. Изучены работы относительно полигенного риска, который показал генетическую коморбидность с тревогой и биполярным расстройством более чем в одной работе. Однако разработанные авторами модели объясняют малый процент дисперсии и слабо повторяются на других выборках. Вероятно, решить эту проблему можно, используя большие выборки и более четкие однородные критерии включения. Таким образом, на настоящий момент исследований GWAS ПТСР мало, они неоднозначны и малоинформативны по сравнению с такими же исследованиями для других психических расстройств, однако имеют дальнейший потенциал для оценки рисков развития болезни.

Ключевые слова:

GWAS

ПТСР

стресс

полигенный риск

Авторы:

Зоркина Я.А.

ФГБУ «Национальный медицинский исследовательский центр психиатрии и наркологии В.П. Сербского» Минздрава России;
ГБУЗ «Психиатрическая клиническая больница №1 им. Н.А. Алексеева Департамента здравоохранения Москвы»

ORCID: 0000-0003-0247-2717

Голубева Е.А.

ГБУЗ «Психиатрическая клиническая больница №1 им. Н.А. Алексеева Департамента здравоохранения Москвы»

ORCID: 0009-0003-4024-5184

Гурина О.И.

ФГБУ «Национальный медицинский исследовательский центр психиатрии и наркологии В.П. Сербского» Минздрава России

ORCID: 0000-0001-6942-5531

Резник А.М.

ГБУЗ «Психиатрическая клиническая больница №1 им. Н.А. Алексеева Департамента здравоохранения Москвы»

ORCID: 0000-0002-7076-5901

Морозова А.Ю.

ORCID: 0000-0002-8681-5299

Дата поступления:

12.07.2024

Дата принятия в печать:

23.10.2024

Список литературы:

Nievergelt CM, Maihofer AX, Atkinson EG, et al. Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder. Nat Genet. 2024;56(5):792-808. https://doi.org/10.1038/s41588-024-01707-9
Резник А.М. Обзор исследований внешних факторов и генетических предпосылок боевого посттравматического стрессового расстройства. Вестник Медицинского института непрерывного образования. 2022;(4):46-54. https://doi.org/10.46393/27821714_2022_4_46
Gates MA, Holowka DW, Vasterling JJ, et al. Posttraumatic stress disorder in veterans and military personnel: epidemiology, screening, and case recognition. Psychol Serv. 2012;9(4):361-382. https://doi.org/10.1037/a0027649
Han X, Shen Q, Hou C, et al. Disease clusters subsequent to anxiety and stress-related disorders and their genetic determinants. Nat Commun. 2024;15(1):1209. Published 2024 Feb 8. https://doi.org/10.1038/s41467-024-45445-2
Stein MB, Levey DF, Cheng Z, et al. Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program. Nat Genet. 2021;53(2):174-184. https://doi.org/10.1038/s41588-020-00767-x
Gelernter J, Sun N, Polimanti R, et al. Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in>165,000 US veterans. Nat Neurosci. 2019;22(9):1394-1401. https://doi.org/10.1038/s41593-019-0447-7
Xie P, Kranzler HR, Yang C, et al. Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder. Biol Psychiatry. 2013;74(9):656-663. https://doi.org/10.1016/j.biopsych.2013.04.013
Logue MW, Baldwin C, Guffanti G, et al. A genome-wide association study of post-traumatic stress disorder identifies the retinoid-related orphan receptor alpha (RORA) gene as a significant risk locus. Mol Psychiatry. 2013;18(8):937-942. https://doi.org/10.1038/mp.2012.113
Wilker S, Schneider A, Conrad D, et al. Genetic variation is associated with PTSD risk and aversive memory: Evidence from two trauma-Exposed African samples and one healthy European sample. Transl Psychiatry. 2018;8(1):251. https://doi.org/10.1038/s41398-018-0297-1
Stein MB, Chen CY, Ursano RJ, et al. Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers. JAMA Psychiatry. 2016;73(7):695-704. https://doi.org/10.1001/jamapsychiatry.2016.0350
Maihofer AX, Choi KW, Coleman JRI, et al. Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information. Biol Psychiatry. 2022;91(7):626-636. https://doi.org/10.1016/j.biopsych.2021.09.020
Wendt FR, Pathak GA, Deak JD, et al. Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder. Mol Psychiatry. 2022;27(4):2206-2215. https://doi.org/10.1038/s41380-022-01469-y
Nievergelt CM, Maihofer AX, Klengel T, et al. International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci. Nat Commun. 2019;10(1):4558. https://doi.org/10.1038/s41467-019-12576-w
Meier SM, Trontti K, Purves KL, et al. Genetic Variants Associated With Anxiety and Stress-Related Disorders: A Genome-Wide Association Study and Mouse-Model Study. JAMA Psychiatry. 2019;76(9):924-932. https://doi.org/10.1001/jamapsychiatry.2019.1119
Stein MB, Levey DF, Cheng Z, et al. Genomic Characterization of Posttraumatic Stress Disorder in a Large US Military Veteran Sample. Nature Genetics. 2020:764001.
Almli LM, Stevens JS, Smith AK, et al. A genome-wide identified risk variant for PTSD is a methylation quantitative trait locus and confers decreased cortical activation to fearful faces. Am J Med Genet B Neuropsychiatr Genet. 2015;168B(5):327-336. https://doi.org/10.1002/ajmg.b.32315
Guffanti G, Galea S, Yan L, et al. Genome-wide association study implicates a novel RNA gene, the lincRNA AC068718.1, as a risk factor for post-traumatic stress disorder in women. Psychoneuroendocrinology. 2013;38(12):3029-3038. https://doi.org/10.1016/j.psyneuen.2013.08.014
Nievergelt CM, Maihofer AX, Mustapic M, et al. Genomic predictors of combat stress vulnerability and resilience in U.S. Marines: A genome-wide association study across multiple ancestries implicates PRTFDC1 as a potential PTSD gene. Psychoneuroendocrinology. 2015;51:459-471. https://doi.org/10.1016/j.psyneuen.2014.10.017
Alloza I, Otaegui D, de Lapuente AL, et al. ANKRD55 and DHCR7 are novel multiple sclerosis risk loci. Genes Immun. 2012;13(3):253-257. https://doi.org/10.1038/gene.2011.81
Kojetin DJ, Burris TP. REV-ERB and ROR nuclear receptors as drug targets. Nat Rev Drug Discov. 2014;13(3):197-216. https://doi.org/10.1038/nrd4100
Jolly S, Journiac N, Naudet F, et al. Cell-autonomous and non-cell-autonomous neuroprotective functions of RORα in neurons and astrocytes during hypoxia. J Neurosci. 2011;31(40):14314-14323. https://doi.org/10.1523/JNEUROSCI.1443-11.2011
Banerjee SB, Morrison FG, Ressler KJ. Genetic approaches for the study of PTSD: Advances and challenges. Neurosci Lett. 2017;649:139-146. https://doi.org/10.1016/j.neulet.2017.02.058
Welin M, Egeblad L, Johansson A, et al. Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1. FEBS J. 2010;277(23):4920-4930. https://doi.org/10.1111/j.1742-4658.2010.07897.x
Wolf EJ, Rasmusson AM, Mitchell KS, et al. A genome-wide association study of clinical symptoms of dissociation in a trauma-exposed sample. Depression and anxiety. 2014;31(4):352-360. https://doi.org/10.1002/da.22260
Ashley-Koch AE, Garrett ME, Gibson J, et al. Genome-wide association study of posttraumatic stress disorder in a cohort of Iraq-Afghanistan era veterans. J Affect Disord. 2015;184:225-234. https://doi.org/10.1016/j.jad.2015.03.049
Chen H, Shi Z, Guo J, et al. The human mitochondrial 12S rRNA m4C methyltransferase METTL15 is required for mitochondrial function. J Biol Chem. 2020;295(25):8505-8513. https://doi.org/10.1074/jbc.RA119.012127
Van Haute L, Hendrick AG, D’Souza AR, et al. METTL15 introduces N4-methylcytidine into human mitochondrial 12S rRNA and is required for mitoribosome biogenesis. Nucleic Acids Res. 2019;47(19):10267-10281. https://doi.org/10.1093/nar/gkz735
Sultana R, Yu CE, Yu J, et al. Identification of a novel gene on chromosome 7q11.2 interrupted by a translocation breakpoint in a pair of autistic twins. Genomics. 2002;80(2):129-134. https://doi.org/10.1006/geno.2002.6810
Beunders G, Voorhoeve E, Golzio C, et al. Exonic deletions in AUTS2 cause a syndromic form of intellectual disability and suggest a critical role for the C terminus. Am J Hum Genet. 2013;92(2):210-220. https://doi.org/10.1016/j.ajhg.2012.12.011
Hori K, Nagai T, Shan W, et al. Cytoskeletal regulation by AUTS2 in neuronal migration and neuritogenesis. Cell Rep. 2014;9(6):2166-2179. https://doi.org/10.1016/j.celrep.2014.11.045
Hori K, Shimaoka K, Hoshino M. AUTS2 Gene: Keys to Understanding the Pathogenesis of Neurodevelopmental Disorders. Cells. 2021;11(1):11. Published 2021 Dec 21. https://doi.org/10.3390/cells11010011
Ji W, Luo Y, Ahmad E, Liu ST. Direct interactions of mitotic arrest deficient 1 (MAD1) domains with each other and MAD2 conformers are required for mitotic checkpoint signaling. J Biol Chem. 2018;293(2):484-496. https://doi.org/10.1074/jbc.RA117.000555
Wan J, Block S, Scribano CM, et al. Mad1 destabilizes p53 by preventing PML from sequestering MDM2. Nat Commun. 2019;10(1):1540. Published 2019 Apr 4. https://doi.org/10.1038/s41467-019-09471-9
Zuko A, Oguro-Ando A, van Dijk R, et al. Developmental role of the cell adhesion molecule Contactin-6 in the cerebral cortex and hippocampus. Cell Adh Migr. 2016;10(4):378-392. https://doi.org/10.1080/19336918.2016.1155018
Lavery K, Swain P, Falb D, Alaoui-Ismaili MH. BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. J Biol Chem. 2008;283(30):20948-20958. https://doi.org/10.1074/jbc.M800850200
Tanaka K, Kaji H, Yamaguchi T, et al. Involvement of the osteoinductive factors, Tmem119 and BMP-2, and the ER stress response PERK-eIF2α-ATF4 pathway in the commitment of myoblastic into osteoblastic cells. Calcif Tissue Int. 2014;94(4):454-464. https://doi.org/10.1007/s00223-013-9828-1
Seeherman HJ, Berasi SP, Brown CT, et al. A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix. Sci Transl Med. 2019;11(489):eaar4953. https://doi.org/10.1126/scitranslmed.aar4953
Shah K, Rossie S. Tale of the Good and the Bad Cdk5: Remodeling of the Actin Cytoskeleton in the Brain. Mol Neurobiol. 2018;55(4):3426-3438. https://doi.org/10.1007/s12035-017-0525-3
Liang Z, Zhan Y, Shen Y, et al. The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines. Nat Commun. 2016;7:13282. https://doi.org/10.1038/ncomms13282
Morohashi Y, Hatano N, Ohya S, et al. Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4. J Biol Chem. 2002;277(17):14965-14975. https://doi.org/10.1074/jbc.M200897200
An WF, Bowlby MR, Betty M, et al. Modulation of A-type potassium channels by a family of calcium sensors. Nature. 2000;403(6769):553-556. https://doi.org/10.1038/35000592
Brereton P, Suzuki T, Sasano H, et al. Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung. Mol Cell Endocrinol. 2001;171(1-2):111-117. https://doi.org/10.1016/s0303-7207(00)00417-2
Hong Y, Jang SW, Ye K. The N-terminal fragment from caspase-cleaved serine/arginine protein-specific kinase2 (SRPK2) translocates into the nucleus and promotes apoptosis. J Biol Chem. 2011;286(1):777-786. https://doi.org/10.1074/jbc.M110.193441
Jang SW, Liu X, Fu H, et al. Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons. J Biol Chem. 2009;284(36):24512-24525. https://doi.org/10.1074/jbc.M109.026237
Radzisheuskaya A, Shliaha PV, Grinev VV, et al. Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis. Mol Cell. 2021;81(8):1749-1765.e8. https://doi.org/10.1016/j.molcel.2021.02.012
Li H, Zhu Y, Morozov YM, et al. Disruption of TCF4 regulatory networks leads to abnormal cortical development and mental disabilities. Mol Psychiatry. 2019;24(8):1235-1246. https://doi.org/10.1038/s41380-019-0353-0
Chen J, Lin M, Hrabovsky A, et al. ZNF804A Transcriptional Networks in Differentiating Neurons Derived from Induced Pluripotent Stem Cells of Human Origin. PLoS One. 2015;10(4):e0124597. https://doi.org/10.1371/journal.pone.0124597
Riley B, Thiselton D, Maher BS, et al. Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample. Mol Psychiatry. 2010;15(1):29-37. https://doi.org/10.1038/mp.2009.109
Steinberg S, Mors O, Børglum AD, et al. Expanding the range of ZNF804A variants conferring risk of psychosis. Mol Psychiatry. 2011;16(1):59-66. https://doi.org/10.1038/mp.2009.149
Kane MS, Diamonstein CJ, Hauser N, et al. Endosomal trafficking defects in patient cells with KIAA1109 biallelic variants. Genes Dis. 2019;6(1):56-67. https://doi.org/10.1016/j.gendis.2018.12.004
de Boer HR, Guerrero Llobet S, van Vugt MA. Controlling the response to DNA damage by the APC/C-Cdh1. Cell Mol Life Sci. 2016;73(5):949-960. https://doi.org/10.1007/s00018-015-2096-7
Ing-Esteves S, Kostadinov D, Marocha J, et al. Combinatorial Effects of Alpha- and Gamma-Protocadherins on Neuronal Survival and Dendritic Self-Avoidance. J Neurosci. 2018;38(11):2713-2729. https://doi.org/10.1523/JNEUROSCI.3035-17.2018
Sheehan K, Lee J, Chong J, et al. Transcription factor Sp4 is required for hyperalgesic state persistence. PLoS One. 2019;14(2):e0211349. Published 2019 Feb 27. https://doi.org/10.1371/journal.pone.0211349
Yadav P, Ahmed T, Park S, et al. EZH2 and matrix co-regulate phenotype and KCNB2 expression in bladder smooth muscle cells. Am J Clin Exp Urol. 2023;11(4):293-303.
Wang P, Anderson DE, Ye Y. PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosis. Cell Biosci. 2023;13(1):179. https://doi.org/10.1186/s13578-023-01128-x
Bommaraju S, Dhokne MD, Arun EV, et al. An insight into crosstalk among multiple signalling pathways contributing to the pathophysiology of PTSD and depressive disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2024;131:110943. https://doi.org/10.1016/j.pnpbp.2024.110943
Bian YY, Yang LL, Zhang B, et al. Identification of key genes involved in post-traumatic stress disorder: Evidence from bioinformatics analysis. World J Psychiatry. 2020;10(12):286-298. https://doi.org/10.5498/wjp.v10.i12.286
Pereira Luppi M, Azcorra M, Caronia-Brown G, et al. Sox6 expression distinguishes dorsally and ventrally biased dopamine neurons in the substantia nigra with distinctive properties and embryonic origins. Cell Rep. 2021;37(6):109975. https://doi.org/10.1016/j.celrep.2021.109975
Nasyrova RF, Moskaleva PV, Vaiman EE, et al. Genetic Factors of Nitric Oxide’s System in Psychoneurologic Disorders. Int J Mol Sci. 2020;21(5):1604. https://doi.org/10.3390/ijms21051604
Nam J, Mah W, Kim E. The SALM/Lrfn family of leucine-rich repeat-containing cell adhesion molecules. Semin Cell Dev Biol. 2011;22(5):492-498. https://doi.org/10.1016/j.semcdb.2011.06.005
Cappello V, Marchetti L, Parlanti P, et al. Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease. Sci Rep. 2016;6(1):1. https://doi.org/10.1038/s41598-016-0001-8
Zhu Y, Yao S, Augustine MM, et al. Neuron-specific SALM5 limits inflammation in the CNS via its interaction with HVEM. Sci Adv. 2016;2(4):e1500637. https://doi.org/10.1126/sciadv.1500637
Babcock KJ, Abdolmohammadi B, Kiernan PT, et al. Interface astrogliosis in contact sport head impacts and military blast exposure. Acta Neuropathol Commun. 2022;10(1):52. https://doi.org/10.1186/s40478-022-01358-z
Laurent CE, Smithgall TE. The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner. Exp Cell Res. 2004;299(1):188-198. https://doi.org/10.1016/j.yexcr.2004.05.010
Huang YL, Pai FS, Tsou YT, et al. Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity. J Biol Chem. 2015;290(35):21252-21263. https://doi.org/10.1074/jbc.M115.649814
Zhang CC, Xing A, Tan MS, et al. The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy. Mol Neurobiol. 2016;53(7):4893-4904. https://doi.org/10.1007/s12035-015-9415-8
Vosberg DE, Leyton M, Flores C. The Netrin-1/DCC guidance system: dopamine pathway maturation and psychiatric disorders emerging in adolescence. Mol Psychiatry. 2020;25(2):297-307. https://doi.org/10.1038/s41380-019-0561-7
Haag N, Schwintzer L, Ahuja R, et al. The actin nucleator Cobl is crucial for Purkinje cell development and works in close conjunction with the F-actin binding protein Abp1. J Neurosci. 2012;32(49):17842-17856. https://doi.org/10.1523/JNEUROSCI.0843-12.2012
Zhang J, Roberts JM, Chang F, et al. Jarid2 promotes temporal progression of retinal progenitors via repression of Foxp1. Cell Rep. 2023;42(4):112416. https://doi.org/10.1016/j.celrep.2023.112416
Van Aubel RA, Smeets PH, van den Heuvel JJ, Russel FG. Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites. Am J Physiol Renal Physiol. 2005;288(2):F327-F333. https://doi.org/10.1152/ajprenal.00133.2004
Swart PC, van den Heuvel LL, Lewis CM, et al. A Genome-Wide Association Study and Polygenic Risk Score Analysis of Posttraumatic Stress Disorder and Metabolic Syndrome in a South African Population. Front Neurosci. 2021;15:677800. Published 2021 Jun 10. https://doi.org/10.3389/fnins.2021.677800
Shen H, Gelaye B, Huang H, et al. Polygenic prediction and GWAS of depression, PTSD, and suicidal ideation/self-harm in a Peruvian cohort. Neuropsychopharmacology. 2020;45(10):1595-1602. https://doi.org/10.1038/s41386-020-0603-5
Saenz de Viteri S, Zhang J, Johnson EC, et al. Genomic risk for post-traumatic stress disorder in families densely affected with alcohol use disorders. Mol Psychiatry. 2023;28(8):3391-3396. https://doi.org/10.1038/s41380-023-02117-9
Zhang KY, Card GL, Suzuki Y, et al. A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases. Mol Cell. 2004;15(2):279-286. https://doi.org/10.1016/j.molcel.2004.07.005
Świerczek A, Jankowska A, Chłoń-Rzepa G, et al. Advances in the Discovery of PDE10A Inhibitors for CNS-Related Disorders. Part 2: Focus on Schizophrenia. Curr Drug Targets. 2019;20(16):1652-1669. https://doi.org/10.2174/1389450120666190801114210
Cibis H, Biyanee A, Dörner W, et al. Characterization of the zinc finger proteins ZMYM2 and ZMYM4 as novel B-MYB binding proteins. Sci Rep. 2020;10(1):8390. Published 2020 May 21. https://doi.org/10.1038/s41598-020-65443-w
Zhang X, Zhou H, Zhang Y, et al. ZNF452 facilitates tumor proliferation and invasion via activating AKT-GSK3β signaling pathway and predicts poor prognosis of non-small cell lung cancer patients. Oncotarget. 2017;8(24):38863-38875. https://doi.org/10.18632/oncotarget.16408
Dahlhoff M, Siegmund A, Golub Y, et al. AKT/GSK-3beta/beta-catenin signalling within hippocampus and amygdala reflects genetically determined differences in posttraumatic stress disorder like symptoms. Neuroscience. 2010;169(3):1216-1226. https://doi.org/10.1016/j.neuroscience.2010.05.066
Ivanova S, Gregorc U, Vidergar N, et al. MAGUKs, scaffolding proteins at cell junctions, are substrates of different proteases during apoptosis. Cell Death Dis. 2011;2(1):e116. https://doi.org/10.1038/cddis.2010.92
Richter G, Gui T, Bourgeois B, et al. β-catenin regulates FOXP2 transcriptional activity via multiple binding sites. FEBS J. 2021;288(10):3261-3284. https://doi.org/10.1111/febs.15656
Tanaka M, Sasaki K, Kamata R, et al. A novel RNA-binding protein, Ossa/C9orf10, regulates activity of Src kinases to protect cells from oxidative stress-induced apoptosis. Mol Cell Biol. 2009;29(2):402-413. https://doi.org/10.1128/MCB.01035-08
Duncan LE, Ratanatharathorn A, Aiello AE, et al. Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability. Mol Psychiatry. 2018;23(3):666-673. https://doi.org/10.1038/mp.2017.77
Adachi N, Hess DT, McLaughlin P, Stamler JS. S-Palmitoylation of a Novel Site in the β2-Adrenergic Receptor Associated with a Novel Intracellular Itinerary. J Biol Chem. 2016;291(38):20232-20246. https://doi.org/10.1074/jbc.M116.725762
Shimura H, Hattori N, Kubo Si, et al. Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat Genet. 2000;25(3):302-305. https://doi.org/10.1038/77060
Barazzuol L, Giamogante F, Brini M, Calì T. PINK1/Parkin Mediated Mitophagy, Ca2+ Signalling, and ER-Mitochondria Contacts in Parkinson’s Disease. Int J Mol Sci. 2020;21(5):1772. https://doi.org/10.3390/ijms21051772
Groot KR, Sevilla LM, Nishi K, et al. Kazrin, a novel periplakin-interacting protein associated with desmosomes and the keratinocyte plasma membrane. J Cell Biol. 2004;166(5):653-659. https://doi.org/10.1083/jcb.200312123
Sekeres MJ, Winocur G, Moscovitch M. The hippocampus and related neocortical structures in memory transformation. Neurosci Lett. 2018;680:39-53. https://doi.org/10.1016/j.neulet.2018.05.006
Roesler R, Parent MB, LaLumiere RT, McIntyre CK. Amygdala-hippocampal interactions in synaptic plasticity and memory formation. Neurobiol Learn Mem. 2021;184:107490. https://doi.org/10.1016/j.nlm.2021.107490
Goto A. Synaptic plasticity during systems memory consolidation. Neurosci Res. 2022;183:1-6. https://doi.org/10.1016/j.neures.2022.05.008
He M, Wei JX, Mao M, et al. Synaptic Plasticity in PTSD and associated Comorbidities: The Function and Mechanism for Diagnostics and Therapy. Curr Pharm Des. 2018;24(34):4051-4059. https://doi.org/10.2174/1381612824666181120094749
Dityatev A, Bukalo O, Schachner M. Modulation of synaptic transmission and plasticity by cell adhesion and repulsion molecules. Neuron Glia Biol. 2008;4(3):197-209. https://doi.org/10.1017/S1740925X09990111
Cullen PK, Ferrara NC, Pullins SE, Helmstetter FJ. Context memory formation requires activity-dependent protein degradation in the hippocampus. Learn Mem. 2017;24(11):589-596. https://doi.org/10.1101/lm.045443.117
Kmita H, Pinna G, Lushchak VI. Potential oxidative stress related targets of mitochondria-focused therapy of PTSD. Front Physiol. 2023;14:1266575. https://doi.org/10.3389/fphys.2023.1266575
Dunlop BW, Wong A. The hypothalamic-pituitary-adrenal axis in PTSD: Pathophysiology and treatment interventions. Prog Neuropsychopharmacol Biol Psychiatry. 2019;89:361-379. https://doi.org/10.1016/j.pnpbp.2018.10.010
Freudenberg F, Alttoa A, Reif A. Neuronal nitric oxide synthase (NOS1) and its adaptor, NOS1AP, as a genetic risk factors for psychiatric disorders. Genes Brain Behav. 2015;14(1):46-63. https://doi.org/10.1111/gbb.12193
Bruenig D, Morris CP, Mehta D, et al. Nitric oxide pathway genes (NOS1AP and NOS1) are involved in PTSD severity, depression, anxiety, stress and resilience. Gene. 2017;625:42-48. https://doi.org/10.1016/j.gene.2017.04.048
Chen HJ, Spiers JG, Sernia C, Lavidis NA. Acute restraint stress induces specific changes in nitric oxide production and inflammatory markers in the rat hippocampus and striatum. Free Radic Biol Med. 2016;90:219-229. https://doi.org/10.1016/j.freeradbiomed.2015.11.023
Ploeger A, Raijmakers ME, van der Maas HL, Galis F. The association between autism and errors in early embryogenesis: what is the causal mechanism? Biol Psychiatry. 2010;67(7):602-607. https://doi.org/10.1016/j.biopsych.2009.10.010
Debnath M, Venkatasubramanian G, Berk M. Fetal programming of schizophrenia: select mechanisms. Neurosci Biobehav Rev. 2015;49:90-104. https://doi.org/10.1016/j.neubiorev.2014.12.003
Hori K, Shimaoka K, Hoshino M. AUTS2 Gene: Keys to Understanding the Pathogenesis of Neurodevelopmental Disorders. Cells. 2021;11(1):11. https://doi.org/10.3390/cells11010011
Haruvi-Lamdan N, Horesh D, Golan O. PTSD and autism spectrum disorder: Co-morbidity, gaps in research, and potential shared mechanisms. Psychol Trauma. 2018;10(3):290-299. https://doi.org/10.1037/tra0000298
Terranova JI, Ogawa SK, Kitamura T. Adult hippocampal neurogenesis for systems consolidation of memory. Behav Brain Res. 2019;372:112035. https://doi.org/10.1016/j.bbr.2019.112035
Fujikawa R, Ramsaran AI, Guskjolen A, et al. Neurogenesis-dependent remodeling of hippocampal circuits reduces PTSD-like behaviors in adult mice. Mol Psychiatry. 2024. https://doi.org/10.1038/s41380-024-02585-7
Cisler JM, Herringa RJ. Posttraumatic Stress Disorder and the Developing Adolescent Brain. Biol Psychiatry. 2021;89(2):144-151. https://doi.org/10.1016/j.biopsych.2020.06.001
Sokolov AV, Manu DM, Nordberg DOT, et al. Methylation in MAD1L1 is associated with the severity of suicide attempt and phenotypes of depression. Clin Epigenetics. 2023;15(1):1. https://doi.org/10.1186/s13148-022-01394-5
Zhou S, Luo H, Tian Y, et al. Investigating the shared genetic architecture of post-traumatic stress disorder and gastrointestinal tract disorders: a genome-wide cross-trait analysis. Psychol Med. 2023;53(16):7627-7635. https://doi.org/10.1017/S0033291723001423
Morozova A, Ushakova V, Pavlova O, et al. BDNF, DRD4, and HTR2A Gene Allele Frequency Distribution and Association with Mental Illnesses in the European Part of Russia. Genes (Basel). 2024;15(2):240. https://doi.org/10.3390/genes15020240
Misganaw B, Guffanti G, Lori A, et al. Polygenic risk associated with post-traumatic stress disorder onset and severity. Transl Psychiatry. 2019;9(1):165. https://doi.org/10.1038/s41398-019-0497-3

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