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Alfimova M.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN

Kondratyev N.V.

Mental Health Research Center, Moscow, Russia

Golimbet V.E.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Results and promises of genetics of cognitive impairment in schizophrenia: molecular-genetic approaches

Authors:

Alfimova M.V., Kondratyev N.V., Golimbet V.E.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(11): 137‑144

DOI: 10.17116/jnevro2016116111137-144

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RESULTS AND PROMISES OF GENETICS OF COGNITIVE IMPAIRMENT IN SCHIZOPHRENIA: MOLECULAR-GENETIC APPROACHES
RESULTS AND PROMISES OF GENETICS OF COGNITIVE IMPAIRMENT IN SCHIZOPHRENIA: MOLECULAR-GENETIC APPROACHES

To cite this article:

Alfimova MV, Kondratyev NV, Golimbet VE. Results and promises of genetics of cognitive impairment in schizophrenia: molecular-genetic approaches. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(11):137‑144. (In Russ.)
https://doi.org/10.17116/jnevro2016116111137-144

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Abstract:

This review highlights the basic paradigms and directions of molecular genetic studies of cognitive deficits in schizophrenia. Along with the traditional approach based on functional candidate genes, it covers genome-wide association studies (GWAS) for cognition in general population and schizophrenic patients, attempts to integrate GWAS results in polygenic profiles that can be used in personalized care of schizophrenic patients, and a search for biological pathways implicated in the development of cognitive impairments with bioinformatics methods. However, despite significant advances in understanding the genetic basis of the disease and a rapidly growing amount of data on genes associated with cognitive functions, most of the variability of cognitive impairments in patients remains unexplained. The data on the functional complexity of the genome accumulated in the fields of molecular biology and genetics underscore the importance of studying epigenetic mechanisms of cognitive deficits in schizophrenia.

Keywords:

schizophrenia
genetic polymorphism
cognitive deficit
GWAS
polygenic profile

Authors:

Alfimova M.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN

Kondratyev N.V.

Mental Health Research Center, Moscow, Russia

Golimbet V.E.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Close metadata

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