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Kazantseva A.V.

Ufa Federal Research Centre of the Russian Academy of Sciences — Institute OF Biochemistry and Genetics

Yakovleva D.V.

Ufa Federal Research Centre of the Russian Academy of Sciences — Institute OF Biochemistry and Genetics;
Ufa University of Science and Technology

Davydova Yu.D.

Ufa Federal Research Centre of the Russian Academy of Sciences — Institute OF Biochemistry and Genetics

Khusnutdinova E.K.

Ufa Federal Research Centre of the Russian Academy of Sciences — Institute OF Biochemistry and Genetics

Replicative study of the involvement of long non-coding RNA genes in the manifestation of antisocial behavior

Authors:

Kazantseva A.V., Yakovleva D.V., Davydova Yu.D., Khusnutdinova E.K.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(11): 145‑150

DOI: 10.17116/jnevro2025125111145

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Table of contents

REPLICATIVE STUDY OF THE INVOLVEMENT OF LONG NON-CODING RNA GENES IN THE MANIFESTATION OF ANTISOCIAL BEHAVIOR
REPLICATIVE STUDY OF THE INVOLVEMENT OF LONG NON-CODING RNA GENES IN THE MANIFESTATION OF ANTISOCIAL BEHAVIOR

To cite this article:

Kazantseva AV, Yakovleva DV, Davydova YuD, Khusnutdinova EK. Replicative study of the involvement of long non-coding RNA genes in the manifestation of antisocial behavior. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(11):145‑150. (In Russ.)
https://doi.org/10.17116/jnevro2025125111145

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To perform replicative analysis of gene loci associated with the risk of antisocial behavior (AB) in European cohorts and the manifestation of extreme forms of AB (murder), considering ethnicity in the Russian sample.

MATERIAL AND METHODS

Two groups of individuals were examined: those with AB (n=227) and the control group (n=254), using logistic regression, in which genetic profile data as well as social and demographic parameters were used as independent variables.

RESULTS

Associations of the rs4714329*G/G variants in the LINK00951 gene (OR=2.92, p=0.006), rs7232069*G variants in the LINK00907 gene (OR=2.0, p=0.006), and rs12977121*A/A variants in the CSNK1G2 gene (OR=1.76, p=0.044) were confirmed with an increased risk of AB among Russians. A significant effect of tobacco smoking on the association of the CSNK1G2 gene locus was found: a higher risk of manifestation of AB extreme forms was observed in persons with nicotine dependence, carriers of the rs12977121*A/A genotype (OR=3.63, p=0.001).

CONCLUSION

The data obtained indicate the potential involvement of long non-coding RNA and casein kinase genes in the development of aggressiveness.

Keywords:

aggression
murder
GWAS
epigenetics
non-coding RNA
biomarkers

Authors:

Kazantseva A.V.

Ufa Federal Research Centre of the Russian Academy of Sciences — Institute OF Biochemistry and Genetics

Yakovleva D.V.

Ufa Federal Research Centre of the Russian Academy of Sciences — Institute OF Biochemistry and Genetics;
Ufa University of Science and Technology

Davydova Yu.D.

Ufa Federal Research Centre of the Russian Academy of Sciences — Institute OF Biochemistry and Genetics

Khusnutdinova E.K.

Ufa Federal Research Centre of the Russian Academy of Sciences — Institute OF Biochemistry and Genetics

Received:

21.07.2025

Accepted:

12.08.2025

Close metadata

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