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Smagina I.V.

Otdelenie nevrologii kraevoĭ klinicheskoĭ bolnitsy, Barnaul;
kafedra nervnykh bolezneĭ s kursom nevrologii i refleksoterapii fakulteta povysheniia kvalifikatsii i PPS, Barnaul;
kafedra biokhimii i klinicheskoĭ laboratornoĭ diagnostiki Altaĭskogo gosudarstvennogo meditsinskogo universiteta, Barnaul;
Novosibirskiĭ gosudarstvennyĭ universitet, Novosibirsk

Elchaninova S.A.

Zolovkina A.G.

Ignatova Iu.N.

Kudriavtseva E.A.

Genetic risk factors for multiple sclerosis in the population of Altay

Authors:

Smagina I.V., Elchaninova S.A., Zolovkina A.G., Ignatova Iu.N., Kudriavtseva E.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(5): 42‑45

Read: 1025 times

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Table of contents

GENETIC RISK FACTORS FOR MULTIPLE SCLEROSIS IN THE POPULATION OF ALTAY
GENETIC RISK FACTORS FOR MULTIPLE SCLEROSIS IN THE POPULATION OF ALTAY

To cite this article:

Smagina IV, Elchaninova SA, Zolovkina AG, Ignatova IuN, Kudriavtseva EA. Genetic risk factors for multiple sclerosis in the population of Altay. S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(5):42‑45. (In Russ.)

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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Использование инфографики авторами научных работ
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Abstract:

The "case-control" research in Russian Altai territory population has proved that DR15 and DR3 as well as the combination of female sex and alleles A of TNFα of rs1800629 locus are associated with high risk of multiple sclerosis. The relationship between disease and CD40 polymorphism (rs6074022) was not found.

Keywords:

multiple sclerosis
DRB1 gene
tumor necrosis factor gene alpha (TNFα)
CD40 gene

Authors:

Smagina I.V.

Otdelenie nevrologii kraevoĭ klinicheskoĭ bolnitsy, Barnaul;
kafedra nervnykh bolezneĭ s kursom nevrologii i refleksoterapii fakulteta povysheniia kvalifikatsii i PPS, Barnaul;
kafedra biokhimii i klinicheskoĭ laboratornoĭ diagnostiki Altaĭskogo gosudarstvennogo meditsinskogo universiteta, Barnaul;
Novosibirskiĭ gosudarstvennyĭ universitet, Novosibirsk

Elchaninova S.A.

Zolovkina A.G.

Ignatova Iu.N.

Kudriavtseva E.A.

Close metadata

References:

  1. Boiko A.N., Favorova O.O. Rasseyannyi skleroz: molekulyarnye i kletochnye mekhanizmy. Molekulyarnaya biologiya 1995; 29: 4: 727
  2. Smagina I.V., Lichenko Yu.N., Fedyanin A.S., El'chaninova S.A. Epidemiologiya rasseyannogo skleroza v Altaiskom krae. Nevrol zhurn 2010; 1: 24-27.
  3. Favorova O.O., Kulakova O.G., Boiko A.N. Rasseyannyi skleroz kak poligennoe zabolevanie: sovremennoe sostoyanie problemy. Genetika 2010; 46: 3: 302-313.
  4. Shmidt T.E., Yakhno N.N. Rasseyannyi skleroz: rukovodstvo dlya vrachei. 2-e izd. M: MEDpress-inform 2010; 272.
  5. Benveniste E.N., Nguyen V.T., Wesemann D.R. Molecular regulation of CD40 gene expression in macrophages and microglia. Brain Behav. Immun 2004; 18: 7-12.
  6. Bomprezzi R., Kovanen P.E., Martin R. New approaches to investigating heterogeneity in complex traits. J Med Genet 2003; 40: 553-559.
  7. Drulovic J., Popadic D., Mesaros S. et al. Decreased frequency of the tumor necrosis factor alpha -308 allele in Serbian patients with multiple sclerosis. Eur Neurol 2003; 50: 1: 25-29.
  8. Duran I. et al. Immunological profile of patiemts with primary progressive multiple sclerosis: expression of adhesion molecules. Brain 1999; 122: 2297-2307.
  9. Favorova O.O., Favorov A.V., Boiko A.N. et al. Three allele combinations associated with Multiple Sclerosis. BMC Med l Genetics 2006; 63: 1-9.
  10. Forte G.I., Ragonese P., Salemi G. et al. Search for Genetic Factors Associated with Susceptibility to Multiple Sclerosis. Annals New York Academy of Sciences 2006; 1067: 264-269.
  11. Kurtzke J.F. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurol 1983; 33: 12: 1444-1452.
  12. Lucotte G., Bathelier C., Mercier G. TNF-α polymorphisms in multiple sclerosis: no association with -238 and - 308 promoter alleles, but the microsatellite allele a II is associated with the disease in French patients. Multple Sclerosis 2000; 6: 2: 78-80.
  13. Orozco G., Eyre S., Hinks A. et al. Association of CD40 with rheumatoid arthritis confirmed in a large UK case-control study. Ann Rheum Dis 2010; 69: 813-816.
  14. Polman C.H., Reingold S.C., Edan C. et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the McDonald. Ann Neurol 2005; 56: 840-864.
  15. Ristić S. et al. Tumor Necrosis Factor-α -308 gene polymorphism in Croatian and Slovenian multiple sclerosis patients. Eur Neurol 2007; 57: 203-207.
  16. Selmaj K., Raine C., Cannella B. et al. Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions. J Clin Invest 1997; 37: 949-954.
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