Quantitative analysis of cerebrospinal fluid flow in multiple sclerosis patients

Nikitin D.V.; Dolgushin M.B.; Boyko A.N.; Boyko O.V.; Kapkanets D.V.; Dvoryanchikov A.V.; Tairova R.T.

doi:https://doi.org/10.17116/jnevro202512507245

Nikitin D.V.

Federal Center of Brain Research and Neurotechnologies

ORCID: 0009-0001-2761-7743

Dolgushin M.B.

Federal Center of Brain and Neurotechnologies of the Federal Medical Biological Agency

ORCID: 0000-0003-3930-5998

Boyko A.N.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency

SPIN RSCI: 9921-9109
Scopus AuthorID: 7102247663
ORCID: 0000-0002-2975-4151

Boyko O.V.

Federal Center for Brain and Neurotechnologies;
N.I. Pirogov Russian National Research Medical University (Pirogov University)

SPIN RSCI: 7244-5490
Scopus AuthorID: 55699162200
ORCID: 0000-0001-7153-5617

Kapkanets D.V.

N.I. Pirogov Russian National Research Medical University (Pirogov University)

ORCID: 0009-0000-0266-0596

Dvoryanchikov A.V.

Federal Center of Brain Research and Neurotechnologies

ORCID: 0009-0009-0678-7821

Tairova R.T.

Federal Center of Brain Research and Neurotechnologies

ORCID: 0000-0002-4174-7114

Quantitative analysis of cerebrospinal fluid flow in multiple sclerosis patients

Authors:

Nikitin D.V., Dolgushin M.B., Boyko A.N., Boyko O.V., Kapkanets D.V., Dvoryanchikov A.V., Tairova R.T.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(7‑2): 45‑50

DOI: 10.17116/jnevro202512507245

Read: 1421 times

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To cite this article:

Nikitin DV, Dolgushin MB, Boyko AN, Boyko OV, Kapkanets DV, Dvoryanchikov AV, Tairova RT. Quantitative analysis of cerebrospinal fluid flow in multiple sclerosis patients. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(7‑2):45‑50. (In Russ.)
https://doi.org/10.17116/jnevro202512507245

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

Использование инфографики авторами научных работ

OBJECTIVE

To study changes in the quantitative indicators of intracranial cerebrospinal fluid (CSF) flow in patients with multiple sclerosis (MS) at different stages of the disease using phase contrast magnetic resonance imaging (PC MRI).

MATERIAL AND METHODS

The study included 80 patients diagnosed with MS (40 in the acute stage, 40 in remission) and 10 healthy volunteers. CSF flow parameters were assessed using a phase contrast MRI protocol. Peak velocities, stroke volume, and positive and negative flow volume through the ventricular aqueduct were analyzed.

RESULTS

In the acute stage, a significant decrease in the studied parameters of cerebrospinal fluid circulation was observed in comparison with patients in remission and the control group (peak positive flow rate was 35% lower on average, peak negative flow rate was 36% lower, positive volume was 49% lower, negative volume was 37% lower). During the remission, the indicators partially recovered but remained below the respective values of healthy volunteers.

CONCLUSIONS

The results indicate a significant disorder of CSF flow in patients with MS in the acute stage, which may be a potential marker of inflammation activity. Phase contrast MRI can be used to monitor the cerebrospinal fluid circulation in MS patients and assess the effectiveness of the treatment.

Keywords:

multiple sclerosis

cerebrospinal fluid

cerebrospinal fluid circulation

phase contrast MRI

Authors:

Nikitin D.V.

Federal Center of Brain Research and Neurotechnologies

ORCID: 0009-0001-2761-7743

Dolgushin M.B.

Federal Center of Brain and Neurotechnologies of the Federal Medical Biological Agency

ORCID: 0000-0003-3930-5998

Boyko A.N.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency

SPIN RSCI: 9921-9109
Scopus AuthorID: 7102247663
ORCID: 0000-0002-2975-4151

Boyko O.V.

Federal Center for Brain and Neurotechnologies;
N.I. Pirogov Russian National Research Medical University (Pirogov University)

SPIN RSCI: 7244-5490
Scopus AuthorID: 55699162200
ORCID: 0000-0001-7153-5617

Kapkanets D.V.

N.I. Pirogov Russian National Research Medical University (Pirogov University)

ORCID: 0009-0000-0266-0596

Dvoryanchikov A.V.

Federal Center of Brain Research and Neurotechnologies

ORCID: 0009-0009-0678-7821

Tairova R.T.

Federal Center of Brain Research and Neurotechnologies

ORCID: 0000-0002-4174-7114

Received:

26.05.2025

Accepted:

25.06.2025

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References:

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