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Sheludchenko V.M.

Krasnov Research Institute of Eye Diseases;
Multidisciplinary Medical Center of Svyatoslav Fedorov Foundation for the Promotion of Advanced Medical Technologies

Yusef Yu.

Krasnov Research Institute of Eye Diseases

Sheludchenko N.V.

Krasnov Research Institute of Eye Diseases

Slavinskaya N.V.

Multidisciplinary Medical Center of Svyatoslav Fedorov Foundation for the Promotion of Advanced Medical Technologies

Diffuse lamellar keratitis: sporadic and cluster forms

Authors:

Sheludchenko V.M., Yusef Yu., Sheludchenko N.V., Slavinskaya N.V.

More about the authors

Journal: Russian Annals of Ophthalmology. 2025;141(4): 34‑40

DOI: 10.17116/oftalma202514104134

Read: 546 times

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Table of contents

DIFFUSE LAMELLAR KERATITIS: SPORADIC AND CLUSTER FORMS
DIFFUSE LAMELLAR KERATITIS: SPORADIC AND CLUSTER FORMS

To cite this article:

Sheludchenko VM, Yusef Yu, Sheludchenko NV, Slavinskaya NV. Diffuse lamellar keratitis: sporadic and cluster forms. Russian Annals of Ophthalmology. 2025;141(4):34‑40. (In Russ.)
https://doi.org/10.17116/oftalma202514104134

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Diffuse lamellar keratitis (DLK) is a known complication of lamellar corneal surgery. The underlying mechanism of the cellular response in DLK is well described. There are two clinical forms — sporadic and cluster — each largely influenced by surgical triggers.

OBJECTIVE

This study analyzes the incidence of different variants of DLK, identifies surgical causes, and outlines distinguishing features and preventive strategies.

MATERIAL AND METHODS

The study included data from 19783 patients aged 18—45 years, among them 97% had myopia, and 3% had hyperopia. Patients in all examined cases underwent Laser-Assisted in Situ Keratomileusis (LASIK).

RESULTS

The incidence of the sporadic form of DLK was 1:110, and the cluster form — 1:20. The main causes of cluster-form DLK were related to toxic surgical agents used in eyelid sanitation, keratomes, and medical gloves. Elimination of these factors stopped the progression of the cluster form. Sporadic DLK was associated with transient triggers disrupting the state of the interface. No DLK cases were recorded in patients undergoing hyperopia correction.

CONCLUSION

The primary surgical trigger for diffuse lamellar keratitis during LASIK is instability of the stromal interface resulting from improper flap repositioning, specific features of planar ablation, and exposure to toxic agents during surgery.

Keywords:

refractive surgery
complications
laser-assisted in situ keratomileusis
diffuse lamellar keratitis

Authors:

Sheludchenko V.M.

Krasnov Research Institute of Eye Diseases;
Multidisciplinary Medical Center of Svyatoslav Fedorov Foundation for the Promotion of Advanced Medical Technologies

Yusef Yu.

Krasnov Research Institute of Eye Diseases

Sheludchenko N.V.

Krasnov Research Institute of Eye Diseases

Slavinskaya N.V.

Multidisciplinary Medical Center of Svyatoslav Fedorov Foundation for the Promotion of Advanced Medical Technologies

Received:

14.01.2025

Accepted:

13.03.2025

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References:

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