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Fursova A.Zh.

Novosibirsk State Regional Hospital;
Novosibirsk State Medical University

Zubkova M.Yu.

Novosibirsk State Regional Hospital;
Novosibirsk State Medical University

Vasilyeva M.A.

Novosibirsk State Regional Clinical Hospital;
Novosibirsk State Medical University

Karlash Yu.A.

Novosibirsk State Regional Hospital;
Novosibirsk State Medical University

Nikulich I.F.

Novosibirsk State Regional Clinical Hospital;
Novosibirsk State Medical University

Derbeneva A.S.

Novosibirsk State Regional Hospital;
Novosibirsk State Medical University

Optical coherence tomography in the diagnosis of multiple sclerosis

Authors:

Fursova A.Zh., Zubkova M.Yu., Vasilyeva M.A., Karlash Yu.A., Nikulich I.F., Derbeneva A.S.

More about the authors

Journal: Russian Annals of Ophthalmology. 2024;140(3): 59‑68

DOI: 10.17116/oftalma202414003159

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To cite this article:

Fursova AZh, Zubkova MYu, Vasilyeva MA, Karlash YuA, Nikulich IF, Derbeneva AS. Optical coherence tomography in the diagnosis of multiple sclerosis. Russian Annals of Ophthalmology. 2024;140(3):59‑68. (In Russ.)
https://doi.org/10.17116/oftalma202414003159

Подписка 2025 (Russian Annals of Ophthalmology)
 
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Multiple sclerosis (MS) is a chronic autoimmune-inflammatory and neurodegenerative disease.

PURPOSE

This study explores the main structural changes in patients with MS and their relationships with the activity and type of disease course.

MATERIAL AND METHODS

This prospective study included 159 patients (318 eyes) with an established diagnosis of MS: group (44 eyes; 13.84%) — relapsing-remitting type MS (RRMS) lasting up to 1 year without a history of optic neuritis (ON); group 2 (30 eyes; 9.43%) — RRMS up to 1 year with ON; group 3 (56 eyes; 17.61%) — RRMS lasting from 1 to 10 years without ON; group 4 (38 eyes; 11.95%) — RRMS from 1 to 10 years with ON; group 5 (49 eyes; 15.41%) — RRMS >10 years without ON; group 6 (37 eyes; 11.63%) — RRMS >10 years with ON; group 7 (34 eyes; 10.69%) — secondary progressive multiple sclerosis (SPMS) without ON; group 8 (30 eyes; 9.43%) — SPMS with ON. Patients underwent standard ophthalmological examinations, including optical coherence tomography.

RESULTS

A decrease in structural parameters was diagnosed, progressing with the duration of the disease and the presence of ON: the minimum values of mGCL+IPL (65.83±9.14 μm) and mSNFL (76.37±14.77 μm) were detected in the group with SPMS with ON. High inverse correlations of EDSS with mGCL+IPL and mRNFL were demonstrated, with maximum in the group with the longest duration of MS without ON (–0.48 and -0.52 (p=0.01), respectively).

CONCLUSION

Changes in the thickness of the structural parameters of the retina, measured by OCT, can be considered as a predictor of the course of MS.

Keywords:

multiple sclerosis
optical coherence tomography
optic neuritis
extended disability rating scale

Authors:

Fursova A.Zh.

Novosibirsk State Regional Hospital;
Novosibirsk State Medical University

Zubkova M.Yu.

Novosibirsk State Regional Hospital;
Novosibirsk State Medical University

Vasilyeva M.A.

Novosibirsk State Regional Clinical Hospital;
Novosibirsk State Medical University

Karlash Yu.A.

Novosibirsk State Regional Hospital;
Novosibirsk State Medical University

Nikulich I.F.

Novosibirsk State Regional Clinical Hospital;
Novosibirsk State Medical University

Derbeneva A.S.

Novosibirsk State Regional Hospital;
Novosibirsk State Medical University

Received:

30.01.2024

Accepted:

18.03.2024

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