The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Safonova T.N.

Krasnov Research Institute of Eye Diseases

Medvedeva E.S.

Regional Clinical Hospital

Medvedeva S.L.

Regional Clinical Hospital

Neuropathic pain in dry eye syndrome. Part 2. Clinical picture, diagnosis and treatment

Authors:

Safonova T.N., Medvedeva E.S., Medvedeva S.L.

More about the authors

Journal: Russian Annals of Ophthalmology. 2023;139(4): 100‑106

Read: 5236 times


To cite this article:

Safonova TN, Medvedeva ES, Medvedeva SL. Neuropathic pain in dry eye syndrome. Part 2. Clinical picture, diagnosis and treatment. Russian Annals of Ophthalmology. 2023;139(4):100‑106. (In Russ.)
https://doi.org/10.17116/oftalma2023139041100

Recommended articles:
Cognitive impairment in patients with multiple scle­rosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):67-73
Early diagnosis and effe­ctive therapy of diabetic poly­neuropathy. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5):62-68
Portopulmonary hype­rtension. Journal of Respiratory Medi­cine. 2025;(2):39-44
Diagnosis and treatment of ovarian cancer in pregnancy. Russian Bulletin of Obstetrician-Gynecologist. 2025;(3):27-33
Sacral dysmorphism in patients with traumatology and orthopedics. Russian Journal of Operative Surgery and Clinical Anatomy. 2025;(2):30-37
Vertebroplasty for pathological vertebral fracture with osteoporosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(6):67-76
Bacterial vagi­nosis: modern views. Russian Journal of Clinical Dermatology and Vene­reology. 2025;(3):261-268

References:

  1. Galor A, Moein HR, Lee C, et al. Neuropathic pain and dry eye. Ocul Surf. 2018;16(1):31-44.  https://doi.org/10.1016/j.jtos.2017.10.001
  2. Rosenthal P, Borsook D. Ocular neuropathic pain. Br J Ophthalmol. 2016; 100(1):128-134.  https://doi.org/10.1136/bjophthalmol-2014-306280
  3. Kalangara JP, Galor A, Levitt RC, Felix ER, Alegret R, Sarantopoulos CD. Burning Eye Syndrome: Do Neuropathic Pain Mechanisms Underlie Chronic Dry Eye? Pain Med. 2016;17(4):746-755.  https://doi.org/10.1093/pm/pnv070
  4. Drew VJ, Tseng CL, Seghatchian J, Burnouf T. Reflections on Dry Eye Syndrome Treatment: Therapeutic Role of Blood Products. Front Med (Lausanne). 2018;5:33. Published 2018 Feb 23.  https://doi.org/10.3389/fmed.2018.00033
  5. Yahno N. Bol’. Prakticheskoe rukovodstvo [Pain. Practical guide]. M.: MEDpress-inform; 2022. (In Russ.).
  6. Levitt AE, Galor A, Chowdhury AR, et al. Evidence that Dry Eye Represents a Chronic Overlapping Pain Condition. Mol Pain. 2017;13:1744806917729306. https://doi.org/10.1177/1744806917729306
  7. Kalangara JP, Galor A, Levitt RC, et al. Characteristics of Ocular Pain Complaints in Patients With Idiopathic Dry Eye Symptoms. Eye Contact Lens. 2017;43(3):192-198.  https://doi.org/10.1097/ICL.0000000000000249
  8. Rosenthal P, Borsook D. The corneal pain system. Part I: the missing piece of the dry eye puzzle. Ocul Surf. 2012;10(1):2-14.  https://doi.org/10.1016/j.jtos.2012.01.002
  9. Rosenthal P, Baran I, Jacobs DS. Corneal pain without stain: is it real? Ocul Surf. 2009;7(1):28-40.  https://doi.org/10.1016/s1542-0124(12)70290-2
  10. Von Hehn CA, Baron R, Woolf CJ. Deconstructing the neuropathic pain phenotype to reveal neural mechanisms. Neuron. 2012;73(4):638-652.  https://doi.org/10.1016/j.neuron.2012.02.008
  11. Sarantopoulos C. Burning mouth syndrome: a misunderstood, underinvestigated, and undertreated clinical challenge. Reg Anesth Pain Med. 2013;38(5): 378-379.  https://doi.org/10.1097/AAP.0b013e3182a3922b
  12. Vehof J, Sillevis Smitt-Kamminga N, Kozareva D, Nibourg SA, Hammond CJ. Clinical Characteristics of Dry Eye Patients With Chronic Pain Syndromes. Am J Ophthalmol. 2016;166:203-204.  https://doi.org/10.1016/j.ajo.2016.03.023
  13. Schuster AK, Wettstein M, Gerhardt A, Eich W, Bieber C, Tesarz J. Eye Pain and Dry Eye in Patients with Fibromyalgia. Pain Med. 2018;19(12): 2528-2535. https://doi.org/10.1093/pm/pny045
  14. Giacomazzi S, Urits I, Hoyt B, et al. Comprehensive Review and Update of Burning Eye Syndrome. J Patient Cent Res Rev. 2021;8(3):255-260. Published 2021 Jul 19.  https://doi.org/10.17294/2330-0698.1813
  15. Wan KH, Chen LJ, Young AL. Depression and anxiety in dry eye disease: a systematic review and meta-analysis. Eye (Lond). 2016;30(12):1558-1567. https://doi.org/10.1038/eye.2016.186
  16. Methodologies to diagnose and monitor dry eye disease: report of the Diagnostic Methodology Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf. 2007;5(2):108-152.  https://doi.org/10.1016/s1542-0124(12)70083-6
  17. Chalmers RL, Begley CG, Caffery B. Validation of the 5-Item Dry Eye Questionnaire (DEQ-5): Discrimination across self-assessed severity and aqueous tear deficient dry eye diagnoses. Cont Lens Anterior Eye. 2010; 33(2):55-60.  https://doi.org/10.1016/j.clae.2009.12.010
  18. Mastropasqua L, Nubile M, Lanzini M, et al. Epithelial dendritic cell distribution in normal and inflamed human cornea: in vivo confocal microscopy study. Am J Ophthalmol. 2006;142(5):736-744.  https://doi.org/10.1016/j.ajo.2006.06.057
  19. Ross AR, Al-Aqaba MA, Almaazmi A, et al. Clinical and in vivo confocal microscopic features of neuropathic corneal pain. Br J Ophthalmol. 2020; 104(6):768-775.  https://doi.org/10.1136/bjophthalmol-2019-314799
  20. Benítez-Del-Castillo JM, Acosta MC, Wassfi MA, et al. Relation between corneal innervation with confocal microscopy and corneal sensitivity with noncontact esthesiometry in patients with dry eye. Invest Ophthalmol Vis Sci. 2007;48(1):173-181.  https://doi.org/10.1167/iovs.06-0127
  21. Tuisku IS, Konttinen YT, Konttinen LM, Tervo TM. Alterations in corneal sensitivity and nerve morphology in patients with primary Sjögren’s syndrome. Exp Eye Res. 2008;86(6):879-885.  https://doi.org/10.1016/j.exer.2008.03.002
  22. Labbé A, Liang Q, Wang Z, et al. Corneal nerve structure and function in patients with non-sjogren dry eye: clinical correlations. Invest Ophthalmol Vis Sci. 2013;54(8):5144-5150. Published 2013 Aug 1.  https://doi.org/10.1167/iovs.13-12370
  23. Pan Q, Angelina A, Marrone M, Stark WJ, Akpek EK. Autologous serum eye drops for dry eye. Cochrane Database Syst Rev. 2017;2(2):CD009327. Published 2017 Feb 28.  https://doi.org/10.1002/14651858.CD009327.pub3
  24. Ortiz MI, Castañeda-Hernández G, Izquierdo-Vega JA, Sánchez-Gutiérrez M, Ponce-Monter HA, Granados-Soto V. Role of ATP-sensitive K+ channels in the antinociception induced by non-steroidal anti-inflammatory drugs in streptozotocin-diabetic and non-diabetic rats. Pharmacol Biochem Behav. 2012;102(1):163-169.  https://doi.org/10.1016/j.pbb.2012.03.032
  25. Kawano T, Zoga V, Gemes G, et al. Suppressed Ca2+/CaM/CaMKII-dependent K(ATP) channel activity in primary afferent neurons mediates hyperalgesia after axotomy. Proc Natl Acad Sci USA. 2009;106(21):8725-8730. https://doi.org/10.1073/pnas.0901815106
  26. McGreevy K, Bottros MM, Raja SN. Preventing Chronic Pain following Acute Pain: Risk Factors, Preventive Strategies, and their Efficacy. Eur J Pain Suppl. 2011;5(2):365-372.  https://doi.org/10.1016/j.eujps.2011.08.013
  27. Mohammadpour M, Jabbarvand M, Nikdel M, Adelpour M, Karimi N. Effect of preemptive topical diclofenac on postoperative pain relief after photorefractive keratectomy. J Cataract Refract Surg. 2011;37(4):633-637.  https://doi.org/10.1016/j.jcrs.2010.10.040
  28. Szucs PA, Nashed AH, Allegra JR, Eskin B. Safety and efficacy of diclofenac ophthalmic solution in the treatment of corneal abrasions. Ann Emerg Med. 2000;35(2):131-137.  https://doi.org/10.1016/s0196-0644(00)70132-6
  29. Goyal S, Hamrah P. Understanding Neuropathic Corneal Pain--Gaps and Current Therapeutic Approaches. Semin Ophthalmol. 2016;31(1-2):59-70.  https://doi.org/10.3109/08820538.2015.1114853
  30. Dimit R, Gire A, Pflugfelder SC, Bergmanson JP. Patient ocular conditions and clinical outcomes using a PROSE scleral device. Cont Lens Anterior Eye. 2013;36(4):159-163.  https://doi.org/10.1016/j.clae.2013.02.004
  31. Song JS, Woo IH, Eom Y, Kim HM. Five Misconceptions Related to Punctal Plugs in Dry Eye Management. Cornea. 2018;37(suppl 1):58-61.  https://doi.org/10.1097/ICO.0000000000001734
  32. Finnerup NB, Attal N, Haroutounian S, et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol. 2015;14(2):162-173.  https://doi.org/10.1016/S1474-4422(14)70251-0
  33. Solov’eva EYu. Therapy for back pain syndrome. Neurology, Neuropsychiatry, Psychosomatics = Nevrologiya, neyropsikhiatriya, psikhosomatika. 2012; (2):96-99. (In Russ.). https://doi.org/10.14412/2074-2711-2012-393
  34. Kurushina OV, Barulin AE, Agarkova OI. Use of parenteral vitamin B complexes in treatment of polyneuropathy. Medical Council = Meditsinskiy sovet. 2018;(18):62-66. (In Russ.). https://doi.org/10.21518/2079-701X-2018-18-62-66
  35. Gratsianskaya AN. Neuromultivit in the treatment of polyneuropathy. Pharmateca = Farmateka. 2007;15:37-41. (In Russ.).
  36. Papanas N, Ziegler D. Efficacy of α-lipoic acid in diabetic neuropathy. Expert Opin Pharmacother. 2014;15(18):2721-2731. https://doi.org/10.1517/14656566.2014.972935
  37. Onysko M, Legerski P, Potthoff J, Erlandson M. Targeting neuropathic pain: consider these alternatives. J Fam Pract. 2015;64(8):470-475. 
  38. Pereverzev AP, Tkacheva ON, Kotovskaya YuV, Onuchina YuS, Dudinskaya EN, Naumov AV. Non-pharmacological Approaches to Treatment of Patients over 60 Years as a Way to Improve Pharmacotherapy Safety and Prevent Polypharmacy. Safety and Risk of Pharmacotherapy = Bezopasnost’ i risk farmakoterapii. 2018;6(4):174-179. (In Russ.). https://doi.org/10.30895/2312-7821-2018-6-4-174-179
  39. Kim BH, Kim MH, Kang SH, Nam HJ. Optimizing acupuncture treatment for dry eye syndrome: a systematic review. BMC Complement Altern Med. 2018;18(1):145. Published 2018 May 3.  https://doi.org/10.1186/s12906-018-2202-0
  40. Nepp J. Psychosomatische Aspekte beim trockenen Auge [Psychosomatic aspects of dry eye syndrome]. Ophthalmologe. 2016;113(2):111-119.  https://doi.org/10.1007/s00347-015-0187-3
  41. Han SB, Yang HK, Hyon JY, Wee WR. Association of dry eye disease with psychiatric or neurological disorders in elderly patients. Clin Interv Aging. 2017;12:785-792. Published 2017 May 15.  https://doi.org/10.2147/CIA.S137580

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.