Differential diagnosis of coccidioidomycosis manifested by peripheral pulmonary lesion

Chashchina M.V.; Sadovnikova S.S.; Chesalina Ya.O.; Briginevich V.E.; Bagirov M.A.

doi:https://doi.org/10.17116/hirurgia202408177

Chashchina M.V.

Central TB Research Institute (CTRI)

ORCID: 0000-0002-0257-5145

Sadovnikova S.S.

Central TB Research Institute (CTRI);
Russian Medical Academy of Continuous Professional Education

ORCID: 0000-0002-6589-2834

Chesalina Ya.O.

Central Tuberculosis Research Institute

ORCID: 0000-0003-1049-5994

Briginevich V.E.

Central TB Research Institute (CTRI)

ORCID: 0009-0008-2799-1293

Bagirov M.A.

Central TB Research Institute (CTRI);
Russian Medical Academy of Continuous Professional Education

ORCID: 0000-0001-9788-1024

Differential diagnosis of coccidioidomycosis manifested by peripheral pulmonary lesion

Authors:

Chashchina M.V., Sadovnikova S.S., Chesalina Ya.O., Briginevich V.E., Bagirov M.A.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2024;(8): 77‑85

DOI: 10.17116/hirurgia202408177

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To cite this article:

Chashchina MV, Sadovnikova SS, Chesalina YaO, Briginevich VE, Bagirov MA. Differential diagnosis of coccidioidomycosis manifested by peripheral pulmonary lesion. Pirogov Russian Journal of Surgery. 2024;(8):77‑85. (In Russ.)
https://doi.org/10.17116/hirurgia202408177

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)

Использование инфографики авторами научных работ

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Abstract:

We present this clinical case as a demonstration of difficulties in differential diagnosis of pulmonary coccidioidomycosis. Differential diagnostics of peripheral pulmonary lesion performed using bronchoscopy with BAL and TBCB and video-assisted thoracic surgery (VATS) biopsy. Diagnostic specimens were tested using microbiological (luminescent microscopy, culture for M. tuberculosis (BACTEC MGIT960 and Lowenstein-Jensen Medium), RT-PCR, cytological and morphological (hematoxylin-eosin, Ziehl—Neelsen, PAS, Grocott methenamine silver (GMS) stainings) examinations. A diagnosis was verified correctly In Russia the country is not endemic for coccidioidomycosis and patient was treated accordingly. Diagnostics of peripheral pulmonary lesions requires of multidisciplinary approaches. Morphological examination, based on detection of only granulomatous inflammation in lung biopsy cannot be used for finally DS and requires microbiological confirmation for TB or other infections, and dynamic monitoring of the patient with concordance their anamnesis vitae and morbi.

Keywords:

coccidioidomycosis

fungal infections

diagnostics

peripheral pulmonary lesion

bronchoscopy

transbronchial cryobiopsy of lung (TBCB)

VATS surgical biopsy

Authors:

Chashchina M.V.

Central TB Research Institute (CTRI)

ORCID: 0000-0002-0257-5145

Sadovnikova S.S.

Central TB Research Institute (CTRI);
Russian Medical Academy of Continuous Professional Education

ORCID: 0000-0002-6589-2834

Chesalina Ya.O.

Central Tuberculosis Research Institute

ORCID: 0000-0003-1049-5994

Briginevich V.E.

Central TB Research Institute (CTRI)

ORCID: 0009-0008-2799-1293

Bagirov M.A.

Central TB Research Institute (CTRI);
Russian Medical Academy of Continuous Professional Education

ORCID: 0000-0001-9788-1024

Received:

28.12.2023

Accepted:

11.01.2024

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