The role of metalloproteinases in the development of primary open-angle glaucoma

Close metadata

Recommended articles:

The effect of phacoemulsification of age-related cataract on intraocular pressure and iridocorneal angle parameters in primary open-angle glaucoma. Russian Annals of Ophthalmology. 2023;(6):60-68

Comparison of the effectiveness and safety of glaucoma drugs in the therapy of primary open-angle glaucoma. Russian Annals of Ophthalmology. 2023;(6):101-108

Factors affecting the hypotensive effect of selective laser trabeculoplasty in primary open-angle glaucoma. Russian Annals of Ophthalmology. 2024;(2):54-62

Pathogenetic basis of optic nerve atrophy in methanol poisoning. Russian Annals of Ophthalmology. 2024;(2):91-96

Possibilities of physiotherapy in glaucomatous optic neuropathy after glaucoma surgery. Russian Annals of Ophthalmology. 2024;(3):88-94

The role of mitochondrial dysfunction in the stabilization of the glaucomatous process. Russian Annals of Ophthalmology. 2024;(4):49-58

Particular and general limitations in gene coding and synonymous recoding of genes. Molecular Genetics, Microbiology and Virology. 2024;(1):43-49

Platelet apoptosis markers under anticoagulation for COVID-19 infection. Russian Journal of Cardiology and Cardiovascular Surgery. 2024;(2):194-203

Features of course of pain syndrome in patients with schwannomatosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(5):48-52

Predicting the risk of decreased ovarian reserve after surgical treatment of patients with deep infiltrative endometriosis using artificial intelligence. Russian Bulletin of Obstetrician-Gynecologist. 2024;(3):92-102

The article reviews literature on the role of matrix metalloproteinases (MMP) in the development of eye pathologies, specifically primary open-angle glaucoma (POAG). Regulation of the extracellular matrix is carried out by proteolytic enzymes — metalloproteinases in particular — as well as specific inhibitors of their activity (tissue metalloproteinases inhibitors). The review also reveals its involvement in the pathogenesis of various types of glaucoma, decrease in stability of the intraocular liquid outflow, proves the role of MMR in the ganglionic apoptosis, remodeling of the optic disk and change of lamina cribrosa in primary open-angle glaucoma. There is research devoted to studying the interrelations of MMP genes with POAG development. Associations of single nucleotide polymorphic loci of MMP-1, MMP-2, MMP-9 genes with POAG are shown.

Keywords:

matrix metalloproteinases

primary open angle glaucoma

apoptosis

extracellular matrix

genes

Authors:

Svinareva D.I.

Belgorod State National Research University

Churnosov M.I.

Belgorod State National Research University

ORCID: 0000-0003-1254-6134

Received:

14.04.2019

Accepted:

08.07.2019

List of references:

Bonnans C, Chou J, Werb Z. Remodelling the extracellular matrix in development and disease. Nat Rev Mol Cell Biol. 2014;15(12):786-801. https://doi.org/10.1038/nrm3904
Rogova LN, Shesternina NV, Zamechnik TV, et al. Matrix metalloproteinases, their role in physiological and pathological processes (review). Vestnik Novyh Medicinskih Tehnologij. 2011;18(2):86-89 (In Russ.).
Sawicki G. Interaction of keratinocytes and fibroblasts modulates the expression of matrix metalloproteinases-2 and -9 and their inhibitors. Mol Cell Biochem. 2005;269(1-2):209-216. https://doi.org/10.1007/s11010-005-3178-x
Moskalenko MI. The involvement of genes of matrix metalloproteinases in the development of arterial hypertension and its complication (review). Nauchnyi rezul’tat. Meditsina i farmatsiya. 2018;4(1):53-69. (In Russ.). https://doi.org/10.18413/2313-8955-2018-4-1-53-69
Gao XJ, Hou SP, Li PH. The association between matrix metalloprotease-9 gene polymorphisms and primary angle-closure glaucomain a Chinese Han population. Int J Ophthalmol. 2014;7(3):397-402.
Micheal S, Qamar R, Akhtar F, Khan MI, Khan WA, Ahmed AM. THFR gene C677T and A1298C polymorphisms and homocysteine levels in primary open angle and primary closed angle glaucoma. Mol Vis. 2009;15:2268-2278.
Määttä M, Tervahartiala T, Vesti E, Airaksinen J, Sorsa T. Levels and activation of matrix metalloproteinases in aqueous humor are elevated in uveitis-related secondary glaucoma. Glaucoma. 2006;15(3):229-237.
Hosseini M, Rose AY, Song K, Bohan C, Alexander JP, Kelley MJ, Acott TS. IL-1 and TNF induction of matrix metalloproteinase-3 by c-Jun N-terminal kinase in trabecular meshwork. Invest Ophthalmol Vis Sci. 2006;47(4): 1469-1476. https://doi.org/10.1167/iovs.05-0451
Rönkkö S, Rekonen P, Kaarniranta K, Puustjärvi T, Teräsvirta M, Uusitalo H. Matrix metalloproteinases and their inhibitors in the chamber angle of normal eyes and patients with primary open-angle glaucoma and exfoliation glaucoma. Graefes Arch Clin Exp Ophthalmol. 2007;245(5):697-704.
Zhuravleva AN, Neroev VV, Andreeva LD. Study of sclera fibronectin in primary open angle glaucoma (immunohistochemistry). Vestnik Oftal’mologii. 2009;3:12-15. (In Russ.).
Arapiev MU, Lovpache DN, Slepova OS, Balackaja NV. Study of regulating factors of the extracellular matrix and biomechanical properties of corneascleral membranes at physiological aging and primary open-angle glaucoma. Nacional’nyj zhurnal Glaukoma. 2015;14(4):13-20. (In Russ.).
Kurysheva NI. Glaukomnaja opticheskaja nejropatija [Glaucoma optic neuropathy]. M.: MEDpress-inform; 2006. (In Russ.).
Golubnitschaja O, Yeghiazaryan K, Liu R, Mönkemann H, Leppert D, Schild H, Haefliger IO, Flammer J. Increased expression of matrix metalloproteinases in mononuclear blood cells of normal-tension glaucoma patients. J Glaucoma. 2004;13(1):66-72. https://doi.org/10.1097/00061198-200402000-00013
Rukina DA, Dogadova LP, Markelova EV, Abdullin EA, Osyhovskij AL, Hohlova AS. Immunological aspects of the pathogenesis of primary open-angle glaucoma. Klinicheskaja oftalmologija. Glaucoma. 2011;4:162-165. (In Russ.).
Singh D, Srivastava SK, Chaudhuri TK, Upadhyay G. Multifaceted role of matrix metalloproteinases (MMPs). Front Mol Biosci. 2015;2. https://doi.org/10.3389/fmolb.2015.00019
De Groef L, Van Hove I, Dekeyster E, Stalmans I, Moons L. MMPs in the neuroretina and optic nerve: modulators of glaucoma pathogenesis and repair? Invest Ophthalmol Vis Sci. 2014;55(3):1953-1964. https://doi.org/10.1167/iovs.13-13630
Nga AD, Yap SL, Samsudin A, Abdul-Rahman PS, Hashim OH, Mimiwati Z. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in the aqueous humour of patients with primary angle closure glaucoma — a quantitative study. BMC Ophthalmol. 2014;14(1):33. https://doi.org/10.1186/1471-2415-14-33
Zolotarev AV, Karlova EV, Lebedev OI, Stoljarov GM. Pharmacological activation of uveoscleral outflow of intraocular fluid in glaucoma: pathogenetic aspects. Vestnik Oftal’mologii. 2013;4:83-87. (In Russ.).
Manabe S, Gu Z, Lipton SA. Activation of matrix metalloproteinase-9 via neuronal nitric oxide synthase contributes to NMDA-induced retinal ganglion cell death. Invest Ophthalmol Vis Sci. 2005;46(12):4747-4753. https://doi.org/10.1167/iovs.05-0128
Cong Y, Guo X, Liu X, Cao D, Jia X, Xiao X, Li S, Fang S, Zhang Q. Association of the single nucleotide polymorphisms in the extracellular matrix metalloprotease-9 gene with PACG in southern China. Mol Vis. 2009;15: 1412-1417.
Ashworth Briggs EL, Toh T, Eri R, Hewitt AW, Cook AL. TIMP1, TIMP2, and TIMP4 are increased in aqueous humor from primary open angle glaucoma patients. Mol Vis. 2015;13(21):1162.
Guo Y, Zhang H, Chen X, Yang X, Cheng W, Zhao K. Association of TP53 polymorphisms with primary open-angle glaucoma: a meta-analysis. Invest Ophthalmol Vis Sci. 2012;53(7):3756-3763. https://doi.org/10.1167/iovs.12-9818
Astahov YuS, Vasilev VB, Rahmanov VV. Mutations and polymorphisms of a miocilin and optineurin genes: value for early diagnostics of primary open angle glaucoma. Klinicheskaja oftalmologija. 2005;6(2):48-51. (In Russ.).
Banerjee D, Bhattacharjee A, Ray K, Ponda AR. Comprehensive analysis of myocilin variants in east Indist POAG patients. Molecul Vis. 2012;18:1548-1557.
Bailey JN, Loomis SJ, Kang JH, et al. Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma. Nat Genet. 2016;48(2):189-194. https://doi.org/10.1038/ng.3482
Choquet H, Paylakhi S, Kneeland SC et al. A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci. Nat Commun. 2018;9(1):2278. https://doi.org/10.1038/s41467-018-04555-4
Gharahkhani P, Burdon KP, Cooke Bailey JN, et al. Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma. Sci Rep. 2018;8(1):3124. https://doi.org/10.1038/s41598-018-20435-9
Shiga Y, Akiyama M, Nishiguchi KM, Sato K, et al. Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma. Hum Mol Genet. 2018;27(8):1486-1496. https://doi.org/10.1093/hmg/ddy053
Aung T, Yong VH, Lim MC, Venkataraman D, Toh JY, Chew PT, Vithana EN. Lack of association between the rs2664538 polymorphism in the MMP-9 gene and primary angle closure glaucoma in Singaporean subjects. J Glaucoma. 2008;4:257-258. https://doi.org/10.1097/IJG.0b013e31815c3aa5
Markiewicz L, Majsterek I, Przybylowska K, Dziki L, Waszczyk M, Gacek M, Kaminska A, Szaflik J, Szaflik JP. Gene polymorphisms of the MMP1, MMP9, MMP12, IL-1β and TIMP1 and the risk of primary open-angle glaucoma. Acta Ophthalmol. 2013;91(7):516-523.
Markiewicz L, Pytel D, Mucha B, Szymanek K, Szaflik J, Szaflik JP, Majsterek I. Altered Expression Levels of MMP1, MMP9, MMP12, TIMP1, and IL-1β as a Risk Factor for the Elevated IOP and Optic Nerve Head Damage in the Primary Open-Angle Glaucoma Patients. Biomed Res Int. 2015; 2015:Article ID 812503, 8 p. https://doi.org/10.1155/2015/812503
Chen X, Chen Y, Wiggs JL, Pasquale LR, Sun X, Fan BJ. Association of Matrix Metalloproteinase-9 (MMP9) Variants with Primary Angle Closure and Primary Angle Closure Glaucoma. PLoS One. 2016;11(6):e0157093. https://doi.org/10.1371/journal.pone.0157093
Awadalla MS, Burdon KP, Kuot A, Hewitt AW, Craig JE. Matrix metalloproteinase-9 genetic variation and primary angle closure glaucoma in a Caucasian population. Mol Vis. 2011;17:1420-1424.
Ussa F, Fernandez I, Brion M, Carracedo A, Blazquez F, Garcia MT, Sanchez-Jara A, De Juan-Marcos L, Jimenez-Carmona S, Juberias JR,Martinez-de-la-Casa JM, Pastor JC. Association between SNPs of Metalloproteinases and Prostaglandin F2α Receptor Genes and Latanoprost Response in Open-Angle Glaucoma. Ophthalmology. 2015;122(5):1040-1048.e4.
Zhang Y, Zhao JL. Role of immune system in glaucomatous optic nerve degeneration. Zhonghua Yan Ke Za Zhi. 2007;43(9):858-861.
Rahmanov VV, Nikitina NYa, Zaharova FM, et al. Mutations and polymorphisms of a miocilin and optineurin genes as genetic risk factors of primary open angle glaucoma development. Genetika = Genetics. 2005;41(11):1567-1574. (In Russ.).
Kirilenko YuA, Bereznikov AI. Influence of a condition of the protein synthesizing device of an organism on a current of primary open angle glaucoma. Glaucoma. 2006;3:16-19. (In Russ.).
Motuschuk AE, Komarova TYu, Grudinina NA, et al. Genetic CYP1B1 and WDR36 options at patients with primary congenital and primary open angle glaucoma from St. Petersburg. Genetika = Genetics. 2009;45(12):1659-1667. (In Russ.).
Tikunova EV, Churnosov MI. Genetic studies of primary open-angle glaucoma. Vestnik Oftal’mologii. 2014;5:96-99. (In Russ.).

Close metadata