The role of metalloproteinases in the development of primary open-angle glaucoma

Svinareva D.I.; Churnosov M.I.

doi:https://doi.org/10.17116/oftalma2020136041146

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Abstract:

The article reviews literature on the role of matrix metalloproteinases (MMP) in the development of eye pathologies, specifically primary open-angle glaucoma (POAG). Regulation of the extracellular matrix is carried out by proteolytic enzymes — metalloproteinases in particular — as well as specific inhibitors of their activity (tissue metalloproteinases inhibitors). The review also reveals its involvement in the pathogenesis of various types of glaucoma, decrease in stability of the intraocular liquid outflow, proves the role of MMR in the ganglionic apoptosis, remodeling of the optic disk and change of lamina cribrosa in primary open-angle glaucoma. There is research devoted to studying the interrelations of MMP genes with POAG development. Associations of single nucleotide polymorphic loci of MMP-1, MMP-2, MMP-9 genes with POAG are shown.

Keywords:

matrix metalloproteinases

primary open angle glaucoma

apoptosis

extracellular matrix

genes

Authors:

Svinareva D.I.

Belgorod State National Research University

Churnosov M.I.

Belgorod State National Research University

ORCID: 0000-0003-1254-6134

Received:

14.04.2019

Accepted:

08.07.2019

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References:

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