Functional rehabilitation of patients after endovitreal surgery of rhegmatogenous retinal detachment with complete retinal attachment

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Rhegmatogenous retinal detachment (RRD) is one of the most severe eye diseases typically occurring in people of working age. The annual rates of primary vision disability in patients with RRD is 2—9%.

PURPOSE

To increase the functional effectiveness of endovitreal surgery in patients with RRD by including Cytoflavin in the system of postoperative rehabilitation.

MATERIAL AND METHODS

The study involved 68 patients with RRD aged 37 to 65 years. Patients underwent vitrectomy using the 25 Gauge technology with endolaser coagulation of rupture zones and silicone oil tamponade in the vitreous cavity. Three months after the surgery, silicone oil was removed from the vitreous cavity. Patients were divided into 2 groups: the main — 34 people who received Cytoflavin in addition to standard therapy, and the control — 34 people receiving only standard postoperative treatment. The time course of the treatment’s functional effectiveness was analyzed using best corrected visual acuity (BCVA) and macular photosensitivity. Laser Doppler flowmetry (LDF) was used to register the microcirculation and microcirculation efficiency indices. Morphological signs of macular ischemia were registered by optical coherence tomography angiography (OCT-A).

RESULTS

Patients of the main group showed higher level of restoration of macular function compared with the control group. The increase in functional activity of the macular area correlated with postoperative dynamics of restoration of central retinal thickness. Analysis of LDF and OCT-A indices showed that improvement of visual functions in patients treated with Cytoflavin is directly related to restoration of chorioretinal blood flow.

CONCLUSION

The use of Cytoflavin in patients after endovitreal surgery of RRD led to improvement of BCVA by an average of 2.6 times and photosensitivity of the macula by 2 times. The visual functions of patients improved after using Cytoflavin due to its positive effect on chorioretinal microcirculation and the density of macular capillary plexuses.

Keywords:

rhegmatogenous retinal detachment

chorioretinal blood flow

laser Doppler flowmetry

optical coherence tomography angiography

Cytoflavin

Authors:

Egorov A.V.

Sechenov First Moscow State Medical University

ORCID: 0000-0002-8082-1495

Egorov V.V.

Khabarovsk branch of S.N. Fyodorov National Medical Research Center «MNTK «Eye Microsurgery»;
Postgraduate Institute for Public Health Specialists

Smoliakova G.P.

Khabarovsk branch of S.N. Fyodorov National Medical Research Center «MNTK «Eye Microsurgery»;
Postgraduate Institute for Public Health Specialists

Khudyakov A.Yu.

Khabarovsk branch of S.N. Fyodorov National Medical Research Center «MNTK «Eye Microsurgery»

Received:

29.04.2020

Accepted:

16.05.2020

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