Clinical course and vital prognosis for uveal melanoma in young patients

Close metadata

Recommended articles:

Circumscribed choroidal hemangioma and non-pigmented choroidal melanoma: clinical, instrumental and molecular genetic features. Russian Annals of Ophthalmology. 2024;(2):5-13

Epigenetic markers of choroidal melanoma. Russian Annals of Ophthalmology. 2024;(3):5-10

Serum neurofilament light chains in assessing the course of multiple sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(1):89-93

Analytical review of respiratory infections role in patients with chronic obstructive pulmonary disease and asthma. Part 1. Characteristics of respiratory infections and their long-term consequences. Russian Journal of Preventive Medicine. 2024;(1):90-96

Analytical review of respiratory infections role in patients with chronic obstructive pulmonary disease and asthma. Part 2. Prevention of occurrence and severe course of respiratory infections. Russian Journal of Preventive Medicine. 2024;(2):103-110

Ischemic stroke in men 18—50 years of age. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(3-2):5-11

Predicting the course of urgent abdominal diseases based on intensity of catabolic phenomena. Pirogov Russian Journal of Surgery. 2024;(4):44-48

Long-term follow-up of adult patients with serial and status course of epileptic seizures. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(4):63-68

Airway management in obese patients: a review. Russian Journal of Anesthesiology and Reanimatology. 2024;(3):67-73

Characteristics of gastric neuroendocrine tumors and the PDX-1 transcription factor expression. Russian Journal of Archive of Pathology. 2024;(3):12-20

The article presents a retrospective analysis of uveal melanoma course which was conducted during 2005-2012 and enrolled 21 patients (13 boys and 8 girls) aged from 1 to 20, representing 1.36% of the total number of patients who had been given treatment over that period. Non-pigmented and poorly pigmented tumors were most common. Morphologically the vast majority of cases were spindle cell tumors. It is shown that most patients of this age group are admitted to specialized medical centers at late stages of the disease, which indicates local lack of early detection and proper ophthalmological assessment.

Keywords:

uveal melanoma

young age

prognosis

Authors:

Saakian S.V.

Moscow Helmholtz Research Institute of Eye Diseases, Moscow, Russia

Amirian A.G.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava Rossii

Tsygankov A.Iu.

FGBU "Moskovskiĭ NII glaznykh bolezneĭ im. Gel'mgol'tsa" Minzdrava Rossii

List of references:

Grishina E.E., Fedotova O.F., Zhitenev V.P. Analiz oftal'moonkologicheskoi patologii u vzroslogo naseleniya Moskvy po dannym MOKB. V kn.: Opukholi i opukholepodobnye zabolevaniya organa zreniya. M 1998; 23-24.
Shirina T.V. Khorioidal'nye melanomy u molodykh. Osobennosti diagnostiki. Sbornik trudov yubileinoi nauchno-prakticheskoi konferentsii "Dostizheniya i perspektivy oftal'moonkologii". M 2001; 82-83.
Apt L. Uveal melanomas in children and adolescents. Int Ophthalmol Clin 1962; 2: 403-410.
Balch C.M., Soong S.J., Gershenwald J.E. Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system. J Clin Oncol 2001; 19: 3622-3634.
Barr C.C., McLean I.W., Zimmerman L.E. Uveal melanoma in children and adolescents. Arch Ophthalmol 1981; 99: 2133-2136.
Barr C.C., McLean I.W., Zimmerman L.E. Uveal melanoma in children and adolescents. Arch Ophthalmol 1991; 98: 1662-1666.
Bergman L., Seregard S., Nilsson B. Incidence of uveal melanoma in Sweden from 1960 to 1998. Invest Ophthalmol Vis Sci 2002; 43: 2579-2583.
Boniuk M., Zimmerman L.E. Occurrence and behavior of choroidal melanomas in eyes subjected to operations for retinal detachment. Trans Am Acad Ophthalmol Otolaryngol 1962; 66: 642-658.
Brodway D. Congenital malignant melanoma of the eye. Cancer 1991; 67: 2642-2652.
Chao C., Martin R.C. II, Ross M.I. Correlation between prognostic factors and increasing age in melanoma. Ann Surg Oncol 2004; 11: 259-264.
Char D.H. History of ocular oncology. Ophthalmology 1996; 103: 8 (Suppl): 96-101.
Conway W.C., Faries M.B., Nicholl M.B. Age-related lymphatic dysfunction in melanoma patients. Ann Surg Oncol 2009; 16: 1548-1552.
Fledelius H., Land A.M. Malignant melanoma of the choroid in an 11-month-old infant. Acta Ophthalmol Copenh 1975; 53: 160-166.
Egan K.M., Seddon J.M., Glynn R.J., Graugudas E.S., Albert D.M. Epidemiologic aspects of uveal melanoma. Surv Ophthalmol 1988; 32: 4: 239-251.
Gailloud C., Zografos L., Bercher L., Uffer S., Egger E. Uveal melanomas in patients less than 20 years of age. Klin Monatsbl Augenheilkd 1992; 200: 428-430.
Gambrelle J., Dayan G., Baggetto L.G., Devouassoux-Shisheboran M. Uvealmelanoma in an 18-year-oldAfricanblackman. Acta Ophthalmol Scand 2005; 83: 1: 134-136.
Gonder J.R., Shields J.A., Albert D.M., Augsburger J.J., Lavin P.T. Uveal malignant melanoma associated with ocular and oculodermal melanocytosis.. Ophthalmology 1982; 89: 953-960.
Greer C.H. Congenital melanoma of the anterior uvea. Arch Ophthalmol 1966; 76: 77-78.
Greene M.H., Sanders R.J., Chu F.C. The familial occurrence of cutaneous melanoma, intraocular melanoma, and the dysplastic nevus syndrome. Am J Ophthalmol 1983; 96: 238-245.
Gunduz K. Choroidal melanoma in 14-year-old patient with ocular melanocytosis. Arch Ophthalmol 1998; 116: 8: 1112-1114.
Gunduz K., Shields C.L., Shields J.A., Eagle R.C. Iris Mammillations as the only sign of ocular melanocytosis in a child with choroidal melanoma. Arch Ophthalmol 2000; 118: 5: 716-717.
Hill J.C., Stannard C., Bowen R.M. Ciliary body malignant melanoma in a black child. J Pediatr Ophthalmol Strabismus 1991; 28: 38-40.
Iscovich J., Ascerman C., Andreev H., Pe'er J., Steinits R. An epidemiological study of posterior uveal melanoma in Israel, 1961-1989. Int J Cancer 1995; 61: 3: 291-295.
Jensen O.A. Malignant melanomas of the human uvea. Recent follow-up of cases in Denmark, 1943-1952. Acta Ophthalmol (Copenh) 1970; 48: 1113-1128.
Kincaid M.C. Uveal melanoma. Cancer Control J 1998; 5: 4: 675-703.
Leonard B.C., Shields J.A., McDonald P.R. Malignant melanomas of the uveal tract in children and young adults. Can J Ophthalmol 1975; 10: 441-449.
Lutz J.M., Cree I.M., Foss A.J. Risk factors for intraocular melanoma and occupational exposure. Br J Ophthalmol 1999; 83: 10: 1190-1193.
Palazzi M.A., Ober M.D., Abreu H.F. Congenital uveal malignant melanoma: a case report. Can J Ophthalmol 2005; 40: 611-615.
Paul E.V., Parnell B.L., Fraker M. Prognosis of malignant melanomas of the choroid and ciliary body. Int Ophthalmol Clin 1962; 2: 387-402.
Pogrezebielski A., Orolwska-Heltzman J., Romanowska-Dixon B. Uveal melanoma in young patients. Grafe's Arch Clin Ophthalmol 2006; 244: 1646-1649.
Posnick J.C., Chen P., Zuker R., Greenberg M.L., Becker L.E., Phillips J. Extensive malignant melanoma of the uvea in childhood: resection and immediate reconstruction with microsurgical and craniofacial techniques. Ann Plast Surg 1993; 31: 265-270.
Reeh M.J., Petersen P., Kobrin J.G., Chenoweth R.G. Malignant melanoma of choroid developing in the eye of a three-year-old boy. Ann Ophthalmol 1979; 11: 1: 57-70.
Romanowska B., Zygulska-Mach H., Ksiezyk M. Survival rate of young patients with malignant choroidal melanoma after conservative treatment. Klin Oczna 1998; 100: 211-216.
Rosenbaum P.S., Boniuk M., Font R.L. Diffuse uveal melanoma in a 5-year-old child. Am J Ophthalmol 1988; 106: 601-606.
Sahel J.O., Steeves R., Albert D. Intraocular melanoma. In: DeVita V, Hellmann S., Rosenberg S.A. Cancer: principles and practice of oncology. Philadelphia: Lippincott-Raven 1997; 1995-2012.
Shields C.L., Shields J.A., Milite J. Uveal melanoma in teenagers and children. A report of 40 cases. Ophthalmology 1991; 98: 1662-1666.
Singh A.D., Shields C.L., Shields J.A., Eagle R.C., De Potter P. Uveal melanoma and familial atypical mole and melanoma (FAM-M) syndrome. Ophthalmic Genet 1995; 16: 53-61.
Singh A.D., De Potter P., Fijal B.A., Shields C.L., Shields J.A., Elston R.C. Lifetime prevalence of uveal melanoma in white patients with oculo (dermal) melanocytosis. Ophthalmology 1998; 105: 195-198.
Singh A.D., Shields C.L., Shields J.A. Uveal melanoma in young patients. Arch Ophthalmol 2000; 118: 7: 918-923.
Singh A.D., Topham A. Incidence of uveal melanoma in the United States: 1973-1997. Ophthalmology 2003; 110: 5: 956-961.
Strouse J.J., Fears T.R., Tucker M.A., Wayne A.S. Pediatric melanoma: risk factor and survival analysis of the surveillance, epidemiology and end results database. J Clin Oncol 2005; 23: 4735-4741.
Taylor M.R., Guerry D.V., Bondi E.E. Lack of association between intraocular melanoma and cutaneous dysplastic nevi. Am J Ophthalmol 1984; 98: 478-482.
Vavvas D., Kim I., Lane A.M., Chaglassian A., Mukai S., Gragoudas E. Posterior uveal melanoma in young patients treated with protonbeam therapy. Retina 2010; 30: 8: 1267-1271.
Verdaguer J.J. Prepuberal and puberal melanomas in ophthalmology. Am J Ophthalmol 1965; 60: 1002-1011.
Vidal J.L., Bacin F., Albuisson E., Rozan R. "Melanoma 92" - epidemiological study of uveal melanoma in France. J Fr Ophthalmol 1995; 18: 8-9: 520-528.

Close metadata