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Skripchenko N.V.

Pediatric Research and Clinical Center for Infectious Diseases;
Saint Petersburg State Pediatric Medical University

Skripchenko E.Yu.

Pediatric Research and Clinical Center for Infectious Diseases;
Saint Petersburg State Pediatric Medical University

Zhdanov K.V.

Pediatric Research and Clinical Center for Infectious Diseases

Alekseeva L.A.

Pediatric Research and Clinical Center for Infectious Diseases

Verbenko P.S.

Pediatric Research and Clinical Center for Infectious Diseases

Susloparova P.S.

Pediatric Research and Clinical Center for Infectious Diseases;
Saint Petersburg State Pediatric Medical University

Pathogenetic aspects of autoantibody formation to central nervous system structures in patients with encephalitis

Authors:

Skripchenko N.V., Skripchenko E.Yu., Zhdanov K.V., Alekseeva L.A., Verbenko P.S., Susloparova P.S.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(4): 53‑58

DOI: 10.17116/jnevro202512504153

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Table of contents

PATHOGENETIC ASPECTS OF AUTOANTIBODY FORMATION TO CENTRAL NERVOUS SYSTEM STRUCTURES IN PATIENTS WITH ENCEPHALITIS
PATHOGENETIC ASPECTS OF AUTOANTIBODY FORMATION TO CENTRAL NERVOUS SYSTEM STRUCTURES IN PATIENTS WITH ENCEPHALITIS

To cite this article:

Skripchenko NV, Skripchenko EYu, Zhdanov KV, Alekseeva LA, Verbenko PS, Susloparova PS. Pathogenetic aspects of autoantibody formation to central nervous system structures in patients with encephalitis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(4):53‑58. (In Russ.)
https://doi.org/10.17116/jnevro202512504153

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

In this article we review the world literature on the influence of infectious agents on the development of autoimmune encephalitis in children and adults, as well as modern ideas about the transformation of infectious encephalitis into autoimmune one. The information is presented about the main links of pathogenesis reflecting the dysfunction of the immune system, which may explain the formation of autoantibodies and the beginning of autoimmune mechanisms of damage to the structures of the central nervous system. The characteristics of laboratory parameters that can be used as prognostic markers to determine the severity of the course of infectious encephalitis and the probability of their transformation into autoimmune encephalitis are given. Proposals are presented on the tactics of etiotropic therapy in patients with suspected infectious encephalitis using the drug meglumine acridone acetate- cycloferon, which has antiviral, immunomodulatory and anti-inflammatory effects.

Keywords:

autoimmune encephalitis
infectious encephalitis
post-infectious encephalitis
children
autoantibodies
prognosis
meglumine acridone acetate-Cycloferon

Authors:

Skripchenko N.V.

Pediatric Research and Clinical Center for Infectious Diseases;
Saint Petersburg State Pediatric Medical University

Skripchenko E.Yu.

Pediatric Research and Clinical Center for Infectious Diseases;
Saint Petersburg State Pediatric Medical University

Zhdanov K.V.

Pediatric Research and Clinical Center for Infectious Diseases

Alekseeva L.A.

Pediatric Research and Clinical Center for Infectious Diseases

Verbenko P.S.

Pediatric Research and Clinical Center for Infectious Diseases

Susloparova P.S.

Pediatric Research and Clinical Center for Infectious Diseases;
Saint Petersburg State Pediatric Medical University

Received:

13.03.2025

Accepted:

14.03.2025

Close metadata

References:

  1. Masciocchi S, Businaro P, Scaranzin S, et al. General features, pathogenesis, and laboratory diagnostics of autoimmune encephalitis. Crit Rev Clin Lab Sci. 2023;61(1):45-69.  https://doi.org/10.1080/10408363.2023.2247482
  2. Polonsky EL, Skulyabin DI, Lapin SV, et al. Polymorphism of autoimmune encephalitis. Annaly klinicheskoi i eksperimental’noi nevrologii. 2019;13(2):79-91. (In Russ.). https://doi.org/10.25692/ACEN.2019.2.9
  3. Dubey D, Pittock SJ, Kelly CR, et al. Autoimmune encephalitis epidemiology and a comparison to infectious encephalitis. Ann Neurol. 2018;83:166-177.  https://doi.org/10.1002/ana.25131
  4. De Bruijn MAAM, Bruijstens AL, Bastiaansen AEM, et al; CHANCE Study Group. Pediatric autoimmune encephalitis: recognition and diagnosis. Neurolo Neuroimmunol Neuroinflammation. 2020;7(3):e682. https://doi.org/10.1212/NXI.0000000000000682
  5. Boucher A, Herrmann JL, Morand P, et al. Epidemiology of infectious encephalitis causes in 2016. Méd Malad Infect. 2017;47:221-235.  https://doi.org/10.1016/j.medmal.2017.02.003
  6. Kharitonova LA, Israfilova OE. The experience of cycloferon use in complex therapy of recurrent respiratory tract infection in children. Rossiiskii vestnik perinatologii i pediatrii. 2018;63:(3);98-104. (In Russ.). https://doi.org/10.21508/1027-4065-2018-63-3-98-104
  7. Romantsov MG, Goryacheva LG, Kovalenko AL. Cycloferon — the experience of use in pediatric practice. Detskie infektsii. 2008;(4):62-86. (In Russ.).
  8. Hor JY, Asgari N, Nakashima I, et al. Epidemiology of Neuromyelitis Optica Spectrum Disorder and Its Prevalence and Incidence Worldwide. Front Neurol. 2020;11:501.  https://doi.org/10.3389/fneur.2020.00501
  9. Hilado M, Banh M, Homans J, et al. Pediatric Autoimmune Encephalitis Following COVID-19 Infection. J Child Neurol. 2022;37(4):268-272.  https://doi.org/10.1177/08830738211069814
  10. Belozerov ES, Bulankov YuI, Vasilev VV, et al. Rukovodstvo po infektsionnym boleznyam. Kniga 1. SPb.: Izdatel’stvo Foliant. 2011. (In Russ.).
  11. Skripchenko NV, Lobzin YuV, Voytenkov VB, et al. Innovations in the management of children’s neuroinfections. Detskie infektsii. 2017;16(3):5-9. (In Russ.). https://doi.org/10.22627/2072-8107-2017-16-3-5-9
  12. Yadav P, Chakraborty P, Jha NK, et al. Molecular Mechanism and Role of Japanese Encephalitis Virus Infection in Central Nervous System-Mediated Diseases. Viruses. 2022;14(12):2686.
  13. Ford B, McDonald A, Srinivasan S. Anti-NMDA receptor encephalitis: a case study and illness overview. Drugs in Context. 2019;8:212589. https://doi.org/10.7573/dic.212589
  14. Belozerov ES, Bulankov YuI, Vasilev VV, et al. Rukovodstvo po infektsionnym boleznyam. Kniga 2. SPb.: Izdatel’stvo Foliant. 2011. (In Russ.).
  15. Hardy D. Autoimmune Encephalitis in Children. Ped Neurol. 2022;132:56-66.  https://doi.org/10.1016/j.pediatrneurol.2022.05.004
  16. Li Q, Fu N, Han Y, et al. Pediatric autoimmune encephalitis and its relationship with infection. Ped Neurol. 2021;120:27-32.  https://doi.org/10.1016/j.pediatrneurol.2021.04.001
  17. Stawicka E. Anti-NMDA receptor encephalitis — the narrative review of literature with particular regard to pediatric population. Psychiatr Pol. 2022;56(6):1315-1326. https://doi.org/10.12740/pp/142990
  18. Armangue T, Leypoldt F, Málaga I, et al. Herpes simplex virus encephalitis is a trigger of brain autoimmunity. Ann Neurol. 2014;75(2):317-323.  https://doi.org/10.1002/ana.24083
  19. Chavez-Castillo M, Ruiz-Garcia M, Herrera-Mora P. Characterization and outcomes of epileptic seizures in Mexican pediatric patients with anti-N-methyl-D-aspartate receptor encephalitis. Cureus. 2020;12(5):e8211. https://doi.org/10.7759/cureus.8211
  20. Armangue T, Spatola M, Vlagea A, et al; Spanish Herpes Simplex Encephalitis Study Group. Frequency, symptoms, risk factors, and outcomes of autoimmune encephalitis after herpes simplex encephalitis: A prospective observational study and retrospective analysis. The Lancet Neurology. 2018;17:760-772.  https://doi.org/10.1016/S1474-4422(18)30244-8
  21. Skripchenko NV, Ivanova MV, Vilnits AA, et al. Neuroinfections in children: Tendencies and prospects. Rossiyskiy Vestnik Perinatologii i Pediatrii. 2016;61(4):9-22. (In Russ.). https://doi.org/10.21508/1027-4065-2016-61-4-9-22
  22. Zheleznikova GF, Skripchenko NV, Ivanova GP, et al. Gerpes viruses and multiple sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(9):133-143. (In Russ.). https://doi.org/10.17116/jnevro201611691133-143
  23. Linnoila JJ, Binnicker MJ, Majed M, et al. CSF herpes virus and autoantibody profiles in the evaluation of encephalitis. Neurol Neuroimmunol Neuroinflammation. 2016;3(4):e245. https://doi.org/10.1212/nxi.0000000000000245
  24. Lopalco PL, Biasio LR. Japanese Encephalitis can be devastating. Ann Igiene. 2024;36(3):370-375. 
  25. Zhang L, Zhang L, Li F, et al. When herpes simplex virus encephalitis meets antiviral innate immunity. Front Immunol. 2023;14:1118236. https://doi.org/10.3389/fimmu.2023.1118236
  26. Prüss H, Finke C, Höltje M, et al. N-methyl-D-aspartate receptor antibodies in herpes simplex encephalitis. Ann Neurol. 2012;72(6):902-911.  https://doi.org/10.1002/ana.23689
  27. Berek K, Beer R, Grams A, et al. Caspr2 antibodies in herpes simplex encephalitis: An extension of the spectrum of virus induced autoimmunity? — A case report. BMC Neurol. 2022;22(1):131.  https://doi.org/10.1186/s12883-022-02637-x
  28. Hacohen Y, Deiva K, Pettingill P, et al. N‐methyl‐D‐aspartate receptor antibodies in post-herpes simplex virus encephalitis neurological relapse. Mov Disord. 2014;29(1):90-96.  https://doi.org/10.1002/mds.25626
  29. Handoko M, Hong W, Espineli E, et al. Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Following Herpes Simplex Virus Encephalitis in a Pediatric Patient. Ped Neurol. 2019;98:85-86.  https://doi.org/10.1016/j.pediatrneurol.2019.05.010
  30. Li J, Xu Y, Ren H, et al. Autoimmune GFAP astrocytopathy after viral encephalitis: A case report. Mult Scler Rel Disord. 2018;21:84-87.  https://doi.org/10.1016/j.msard.2018.02.020
  31. Mohammad SS, Sinclair K, Pillai S, et al. Herpes simplex encephalitis relapse with chorea is associated with autoantibodies to N-Methyl-D-aspartate receptor or dopamine-2 receptor. Mov Disord. 2014;29(1):117-122.  https://doi.org/10.1002/mds.25623
  32. Cleaver J, Jeffery K, Klenerman P, et al. The immunobiology of herpes simplex virus encephalitis and post-viral autoimmunity. Brain. 2024;147(4):1130-1148. https://doi.org/10.1093/brain/awad419
  33. George BP, Schneider EB, Venkatesan A. Encephalitis hospitalization rates and inpatient mortality in the United States, 2000-2010. PLoS One. 2014;9(9):e104169. https://doi.org/10.1371/journal.pone.0104169
  34. Nabizadeh F, Balabandian M, Sodeifian F, et al. Autoimmune encephalitis associated with COVID-19: A systematic review. Mult Scler Rel Disord. 2022;62:103795. https://doi.org/10.1016/j.msard.2022.103795
  35. Sánchez-Morales AE, Urrutia-Osorio M, Camacho-Mendoza E, et al. Neurological manifestations temporally associated with SARS-CoV-2 infection in pediatric patients in Mexico. Child’s Nerv Syst. 2021;37(7):2305-2312. https://doi.org/10.1007/s00381-021-05104-z
  36. Bhagat R, Kwiecinska B, Smith N, et al. New-Onset Seizure With Possible Limbic Encephalitis in a Patient With COVID-19 Infection: A Case Report and Review. J Invest Med High Impact Case Rep. 2021;9:2324709620986302. https://doi.org/10.1177/2324709620986302
  37. Liu K, Pan M, Xiao Z, et al. Neurological manifestations of the coronavirus (SARS-CoV-2) pandemic 2019-2020. J Neurol Neurosurg Psychiatry. 2020;91(6):669-670.  https://doi.org/10.1136/jnnp-2020-323177
  38. Guilmot A, Maldonado Slootjes S, Sellimi A, et al. Immune-mediated neurological syndromes in SARS-CoV-2-infected patients. J Neurol. 2021;268(3):751-757.  https://doi.org/10.1007/s00415-020-10108-x
  39. Achar A, Ghosh C. COVID-19-Associated Neurological Disorders: The Potential Route of CNS Invasion and Blood-Brain Relevance. Cells. 2020;9(11):2360. https://doi.org/10.3390/cells9112360
  40. Dhillon PS, Dineen RA, Morris H, et al. Neurological Disorders Associated With COVID-19 Hospital Admissions: Experience of a Single Tertiary Healthcare Center. Front Neurol. 2021;12:640017. https://doi.org/10.3389/fneur.2021.640017
  41. Vasilevska V, Guest PC, Szardenings M, et al. Possible temporal relationship between SARS-CoV-2 infection and anti-NMDA receptor encephalitis: a meta-analysis. Transl Psychiatry. 2024;14(1):139.  https://doi.org/10.1038/s41398-024-02831-0
  42. Linnoila JJ, Rosenfeld MR, Dalmau J. Neuronal surface antibody-mediated autoimmune encephalitis. Semin Neurol. 2014;34(4):458-466.  https://doi.org/10.1055/s-0034-1390394
  43. Klein da Costa B, Brant de F, et al. Unraveling B lymphocytes in CNS inflammatory diseases: Distinct mechanisms and treatment targets. Neurology. 2020;95(16):733-744.  https://doi.org/10.1212/wnl.0000000000010789
  44. Castellazzi M, Contini C, Tamborino C, et al. Epstein-Barr virus-specific intrathecal oligoclonal IgG production in relapsing-remitting multiple sclerosis is limited to a subset of patients and is composed of low-affinity antibodies. J Neuroinflamm. 2014;11(8):188.  https://doi.org/10.1186/s12974-014-0188-1
  45. Lindsey JW. Antibodies to the Epstein-Barr virus proteins BFRF3 and BRRF2 cross-react with human proteins. J Neuroinflamm.2017;310:131-134.  https://doi.org/10.1016/j.jneuroim.2017.07.013
  46. Prüss H. Postviral autoimmune encephalitis: manifestations in children and adults. Curr Opin Neurol. 2017;30(3):327-333.  https://doi.org/10.1097/wco.0000000000000445
  47. Pierson ER, Wagner CA, Goverman JM. The contribution of neutrophils to CNS autoimmunity. Clin Immunol. 2018;189:23-28.  https://doi.org/10.1016/j.clim.2016.06.017
  48. Liu B, Ai P, Zheng D, et al. Cerebrospinal fluid pentraxin 3 and CD40 ligand in anti-N-menthyl-d-aspartate receptor encephalitis. Cerebrospinal fluid pentraxin 3 and CD40 ligand in antiN-menthyl-d-aspartate receptor encephalitis. J Neuroimmunol. 2018;315:40-44.  https://doi.org/10.1016/j.jneuroim.2017.11.016
  49. Mueller SH, Färber A, Prüss H, et al; German Network for Research on Autoimmune Encephalitis (GENERATE). Genetic predisposition in anti-LGI1 and anti-NMDA receptor encephalitis. Ann Neurol. 2018;83(4):863-869.  https://doi.org/10.1002/ana.25216
  50. Binks S, Varley J, Lee W, et al. Distinct HLA associations of LGI1 and CASPR2-antibody diseases. Brain. 2018;141(8):2263-2271. https://doi.org/10.1093/brain/awy109
  51. Shu Y, Qiu W, Zheng J, et al. HLA class II allele DRB1*16:02 is associated with anti-NMDAR encephalitis. J Neurol Neurosurg Psychiatry. 2019;90(6):652-658.  https://doi.org/10.1136/jnnp-2018-319714
  52. Piquet AL, Clardy SL. Infection, Immunodeficiency, and Inflammatory Diseases in Autoimmune Neurology. Semin Neurol. 2018;38(3):379-391.  https://doi.org/10.1055/s-0038-1660820
  53. Venkatesan A, Michael BD, et al. Acute encephalitis in immunocompetent adults. The Lancet. 2019;393:702-716.  https://doi.org/10.1016/s0140-6736(18)32526-1
  54. Bukhalko MA, Skripchenko NV, Skripchenko EYu, et al. significance of gene polymorphism of vitamin D receptor in human pathology. Rossiyskiy Vestnik Perinatologii i Pediatrii. 2017;62(6):23-28. (In Russ.). https://doi.org/10.21508/1027-4065-2017-62-6-23-28
  55. Day GS, Yarbrough MY, Körtvelyessy P, et al. Prospective Quantification of CSF Biomarkers in Antibody-Mediated Encephalitis. Neurology. 2021;96(20):e2546-e2557. https://doi.org/10.1212/wnl.0000000000011937
  56. Zhang H, Therriault J, Kang MS, et al. Alzheimer’s Disease Neuroimaging Initiative. Cerebrospinal fluid synaptosomal-associated protein 25 is a key player in synaptic degeneration in mild cognitive impairment and Alzheimer’s disease. Alzh Res Ther. 2018;10(1):80.  https://doi.org/10.1186/s13195-018-0407-6
  57. Chen J, Ding Y, Zheng D, et al. Elevation of YKL-40 in the CSF of Anti-NMDAR Encephalitis Patients Is Associated With Poor Prognosis. Front Neurol. 2018;9:727.  https://doi.org/10.3389/fneur.2018.00727
  58. Peng Y, Liu B, Pei S, et al. Higher CSF Levels of NLRP3 Inflammasome Is Associated With Poor Prognosis of Anti-N-methyl-D-Aspartate Receptor Encephalitis. Front Immunol. 2019;10:905.  https://doi.org/10.3389/fimmu.2019.00905
  59. Ciano-Petersen NL, Cabezudo-García P, Muñiz-Castrillo S, et al. Current Status of Biomarkers in Anti-N-Methyl-D-Aspartate Receptor Encephalitis. Int J Mol Sci. 2021;22(23):13127. https://doi.org/10.3390/ijms222313127
  60. Alekseeva LA, Zheleznikova GF, Gorelik EY, et al. Cytokines and neuro-specific proteins in viral encephalitis and convulsive syndrome in children. II. Convulsive syndrome. Infektsiya i immunitet. 2021;11(3):433-446. (In Russ.). https://doi.org/10.15789/2220-7619-CAN-1449
  61. Skripchenko NV, Alekseeva LA, Zheleznikova GF. Cerebrospinal fluid and its clinical significance in infectious diseases of the nervous system. Pediatr. 2011;2(3):21-31. (In Russ.).
  62. Leypoldt F, Höftberger R, Titulaer MJ, et al. Investigations on CXCL13 in anti-N-methyl-D-aspartate receptor encephalitis: a potential biomarker of treatment response. JAMA Neurology. 2015;72(2):180-186.  https://doi.org/10.1001/jamaneurol.2014.2956
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