Relationship between stroke-associated pneumonia and long-term outcomes of ischemic stroke

Dolgova I.N.; Santikova L.V.; Chipova D.T.

doi:https://doi.org/10.17116/jnevro202512503157

Dolgova I.N.

Stavropol State Medical University

ORCID: 0000-0002-3079-7319

Santikova L.V.

Kabardino-Balkarian State University named after H.M. Berbekov

ORCID: 0000-0002-3361-6819

Chipova D.T.

Kabardino-Balkarian State University named after H.M. Berbekov;
City Clinical Hospital No. 1

ORCID: 0000-0002-1641-3681

Relationship between stroke-associated pneumonia and long-term outcomes of ischemic stroke

Authors:

Dolgova I.N., Santikova L.V., Chipova D.T.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(3): 57‑61

DOI: 10.17116/jnevro202512503157

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To cite this article:

Dolgova IN, Santikova LV, Chipova DT. Relationship between stroke-associated pneumonia and long-term outcomes of ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(3):57‑61. (In Russ.)
https://doi.org/10.17116/jnevro202512503157

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

Использование инфографики авторами научных работ

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OBJECTIVE

To study the relationship between stroke-associated pneumonia (SAP) and long-term outcomes of ischemic stroke (IS).

MATERIALS AND METHODS

The study included 95 patients with acute IS; Group 1 included 41 patients with SAP history; Group 2 included 54 patients without infectious complications in the acute period of IS. The severity of neurological deficit, the ability to self-care (NIHSS scale, Barthel Index), and the state of cognitive functions (MMSE, MoCA scales) were assessed at hospitalization, on days 5 and 11 of IS, after 6 and 12 months. Blood cell composition, neutrophils/monocytes ratio (NMR), and C-reactive protein were also assessed.

RESULTS

The risk of developing SAP was significantly higher in older IS patients with type 2 diabetes mellitus and a more pronounced baseline neurological deficit (p<0.05 for all conditions). Patients with SAP have a significantly higher hospital mortality and a more severe neurological deficit and cognitive impairment at discharge. After 6 months, the severity of neurological and cognitive impairment in patients with and without SAP was not significantly different.

CONCLUSION

The presence of SAP slows down the recovery of impaired functions in patients with IS for six months from the onset of the disease. NMR is a sensitive marker of SAP.

Keywords:

acute ischemic stroke

atherothrombotic stroke

cardioembolic stroke

cognitive disorders

stroke-associated pneumonia

prognosis

disease outcome

Authors:

Dolgova I.N.

Stavropol State Medical University

ORCID: 0000-0002-3079-7319

Santikova L.V.

Kabardino-Balkarian State University named after H.M. Berbekov

ORCID: 0000-0002-3361-6819

Chipova D.T.

Kabardino-Balkarian State University named after H.M. Berbekov;
City Clinical Hospital No. 1

ORCID: 0000-0002-1641-3681

Received:

17.03.2025

Accepted:

19.03.2025

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References:

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