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Diagnostic and prognostic potential of modern biomarkers in community-acquired pneumonia in children
Journal: Russian Journal of Preventive Medicine. 2025;28(4): 130‑135
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To cite this article:
Belykh NA, Zhuleva AYu, Anikeeva NA. Diagnostic and prognostic potential of modern biomarkers in community-acquired pneumonia in children. Russian Journal of Preventive Medicine.
2025;28(4):130‑135. (In Russ.)
https://doi.org/10.17116/profmed202528041130
Community-acquired pneumonia (CAP) is one of the leading causes of death in children worldwide. Differential diagnosis and assessment of the CAP severity are crucial for optimizing medical care in pediatric patients. Various assessment tools, including biomarkers, can be used for this purpose in clinical practice.
To present and summarize information on the diagnostic and prognostic values of the most promising biomarkers for differential diagnosis and assessment of the severity of the course and outcomes of CAP in children.
A search was conducted for publications on the use of modern markers such as C-reactive protein, procalcitonin, mid-regional proadrenomedullin, presepsin, serum soluble triggering receptor expressed on myeloid cells-1, surfactant protein D, and heparin-binding protein for differential diagnosis and assessment of CAP severity in children. PubMed and MedLine databases were used.
A review of the literature data showed that the above markers, each with its own advantages and limitations, can be considered promising diagnostic and prognostic tools for pediatric CAP. A universal biomarker that can be used to differentially diagnose the etiological factors of CAP and assess the severity of the course and prognosis of the disease has not been identified yet.
It is necessary to continue searching for new markers and studying the value of already known ones in assessing the risk of adverse outcomes of community-acquired pneumonia in children.
Authors:
Received:
15.11.2024
Accepted:
21.01.2025
List of references:
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