Diagnostic and prognostic potential of modern biomarkers in community-acquired pneumonia in children

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OBJECTIVE

To present and summarize information on the diagnostic and prognostic values of the most promising biomarkers for differential diagnosis and assessment of the severity of the course and outcomes of CAP in children.

MATERIALS AND METHODS

A search was conducted for publications on the use of modern markers such as C-reactive protein, procalcitonin, mid-regional proadrenomedullin, presepsin, serum soluble triggering receptor expressed on myeloid cells-1, surfactant protein D, and heparin-binding protein for differential diagnosis and assessment of CAP severity in children. PubMed and MedLine databases were used.

RESULTS

A review of the literature data showed that the above markers, each with its own advantages and limitations, can be considered promising diagnostic and prognostic tools for pediatric CAP. A universal biomarker that can be used to differentially diagnose the etiological factors of CAP and assess the severity of the course and prognosis of the disease has not been identified yet.

CONCLUSION

It is necessary to continue searching for new markers and studying the value of already known ones in assessing the risk of adverse outcomes of community-acquired pneumonia in children.

Keywords:

community-acquired pneumonia

children

biomarkers

differential diagnosis

prognosis

Authors:

Belykh N.A.

Academician I.P. Pavlov Ryazan State Medical University

ORCID: 0000-0002-5533-0205

Zhuleva A.Yu.

Academician I.P. Pavlov Ryazan State Medical University

ORCID: 0000-0002-6926-2418

Anikeeva N.A.

Academician I.P. Pavlov Ryazan State Medical University

ORCID: 0000-0003-1103-2019

Received:

15.11.2024

Accepted:

21.01.2025

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