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Batrakova T.V.

V.A. Almazov National Medical Research Center

Punchenko O.E.

Institute of Experimental Medicine

Ermolenko E.I.

V.A. Almazov National Medical Research Center;
Institute of Experimental Medicine

Zazerskaya I.E.

V.A. Almazov National Medical Research Center

Probiotics in the treatment and prevention of vaginitis in pregnant women

Authors:

Batrakova T.V., Punchenko O.E., Ermolenko E.I., Zazerskaya I.E.

More about the authors

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To cite this article:

Batrakova TV, Punchenko OE, Ermolenko EI, Zazerskaya IE. Probiotics in the treatment and prevention of vaginitis in pregnant women. Russian Bulletin of Obstetrician-Gynecologist. 2025;25(5):22‑26. (In Russ.)
https://doi.org/10.17116/rosakush20252505122

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References:

  1. Clinical recommendations (treatment protocol) of the Ministry of Health of the Russian Federation « Inflammatory diseases of the cervix, vagina and vulva». 2021. (In Russ.).
  2. Badikov VD, Borukhovich DG. The frequency of detection of laboratory signs of aerobic vaginitis in pregnant women and women with pathological vaginal discharge syndrome. St. Petersburg Dermatological readings. 2020;10-12. (In Russ.).
  3. Tsonis O, Gkrozou F, Harrison E, Stefanidis K, Vrachnis N, Paschopoulos M. Female genital tract microbiota affecting the risk of preterm birth: What do we know so far? A review. Eur J Obstet Gynecol Reprod Biol. 2020;245:168-173.  https://doi.org/10.1016/j.ejogrb.2019.12.005
  4. Soyer Caliskan C, Yurtcu N, Celik S, Sezer O, Kilic SS, Cetin A. Derangements of vaginal and cervical canal microbiota determined with real-time PCR in women with recurrent miscarriages. J Obstet Gynaecol. 2022;42:6:2105-2114. https://doi.org/10.1080/01443615.2022.2033183
  5. Ang XY, Chung FY, Lee BK, Azhar SNA, Sany S, Roslan NS, Ahmad N, Yusof SM, Abdullah N, Nik Ab Rahman NN, Abdul Wahid N, Deris ZZ, Oon CE, Wan Adnan WF, Liong MT. Lactobacilli reduce recurrences of vaginal candidiasis in pregnant women: a randomized, double-blind, placebo-controlled study. J Appl Microbiol. 2022;132:4:3168-3180. https://doi.org/10.1111/jam.15158
  6. Nyirjesy P, Brookhart C, Lazenby G, Schwebke J, Sobel JD. Vulvovaginal Candidiasis: A Review of the Evidence for the 2021 Centers for Disease Control and Prevention of Sexually Transmitted Infections Treatment Guidelines. Clin Infect Dis. 2022;74:Suppl_2: S162—S168. https://doi.org/10.1093/cid/ciab1057
  7. Toktar LR, Mikhaleva LM, Li KI, Pak VE, Midiber KYu, Samsonova IA, Gaifulin RF. Recurrent vaginitis as a major predictor of obstetric perineal injury: searching for evidence. Akusherstvo i ginekologiya: novosti, mneniya, obuchenie. 2023;11:Supplement:74-84. (In Russ.). https://doi.org/10.33029/2303-9698-2023-11-suppL-74-84
  8. Kuznetsova NB, Bushtyreva IO, Dybova VS, Barinova VV, Polev DE, Aseev MV, Dudurich VV. Vaginal microbiome in pregnant women with preterm prelabor rupture of membranes at 22-28 weeks’ gestation. Akusherstvo i ginekologiya. 2021;1:94-102. (In Russ.). https://doi.org/10.18565/aig.2021.1.94-102
  9. Dolgushina VF, Alikhanova ES, Grafova ED. Cervical insufficiency and genital infection. Mediko-farmatsevticheskii zhurnal «Pul`s». 2021;23:8:77-87. (In Russ). https://doi.org/10.26787/nydha-2686-6838-2021-23-8-77-87
  10. Spiridonova NV., Kaganova MA., Devyatova OO., Bezrukova AA. Cervical canal microbiota features in second trimester of pregnancy in insuficiencia istmicocervical with clinical signs of vulvovaginitis depending on vaginal discharge pH. Doktor.Ru. 2021;20:6:12-19. (In Russ.). https://doi.org/10.31550/1727-2378-2021-20-6-12-19
  11. Clinical recommendations (treatment protocol) of the Ministry of Health of the Russian Federation «Isthmic-cervical insufficiency». 2021. (In Russ.).
  12. Tikhomirova EV, Kruchinina EV, Tsar’kova AV, Balan VE, Levkovich EA, Titchenko YuP, Chechneva MA, Ovchinnikova VV, Chikisheva ES. Normalization of vaginal microflora in patients with cervical insufficiency. Russian Bulletin of Obstetrician-Gynecologist. 2022;22:3:87-92. (In Russ.). https://doi.org/10.17116/rosakush20222203187
  13. Il’ina IYu, Dobrokhotova YuE. Bacterial vaginosis. Possible solutions to the problem. RMZh. 2020;11:76-78. (In Russ.).
  14. Punchenko OE, Bereznitskaya EA, Ermolenko EI. Microbiota of female genital organs: norm, pathology, ways of correction. Akusherstvo i ginekologiya. 2021;3:18-24. (In Russ.). https://doi.org/10.18565/aig.2021.3.18-24
  15. Leonova MV. Probiotics in the treatment of vaginal infections: efficacy from the perspective of evidence-based medicine. Meditsinskii sovet. 2020;13:148-154. (In Russ.). https://doi.org/10.21518/2079-701X-2020-13-148-154
  16. Vieira-Baptista P, Stockdale CK, Sobel. International Society for the Study of Vulvovaginal. Disease recommendations for the diagnosis and treatment of vaginitis. Lisbon: Admedic, 2023. https://doi.org/10.59153/adm.rdtv.001
  17. Ermolenko EI, Punchenko OE, Voropaeva LS, Swarwal’ AV, Kotyleva MP, Suvorov AN. Probiotics and autoprobiotics in the treatment of experimental vaginitis. Antibiotiki i khimioterapiya. 2022;67:11-12:29-35. (In Russ.). https://doi.org/10.37489/0235-2990-2022-67-11-12-29-35
  18. Dikke GB. Probiotics in restoring normal vaginal microbiocenosis and preventing recurrence of bacterial infections. Farmateka. 2019;26:6:97-105. (In Russ.). https://doi.org/10.18565/pharmateca.2019.6.97-105
  19. Mizgier M, Jarzabek-Bielecka G, Mruczyk K, Kedzia W. The role of diet and probiotics in prevention and treatment of bacterial vaginosis and vulvovaginal candidiasis in adolescent girls and non-pregnant women. Ginekol Pol. 2020;91:7:412-416.  https://doi.org/10.3389/fmicb.2022.787119
  20. Petrova MI, Lievens E, Malik S, Imholz N, Lebeer S. Lactobacillus species as biomarkers and agents that can promote various aspects of vaginal health. Front Physiol. 2015;6:81.  https://doi.org/10.3389/fphys.2015.00081
  21. Zheng J, Wittouck S, Salvetti E, Franz CMAP, Harris HMB, Mattarelli P, O’Toole PW, Pot B, Vandamme P, Walter J, Watanabe K, Wuyts S, Felis GE, Gänzle MG, Lebeer S.A taxonomic note on the genus Lactobacillus: Description of 23 novel genera, emended description of the genus Lactobacillus Beijerinck 1901, and union of Lactobacillaceae and Leuconostocaceae. Int J Systematic Evolutionary Microbiol. 2020;70:4:2782-2858. https://doi.org/10.1099/ijsem.0.004107
  22. Strus M, Chmielarczyk A, Kochan P, Adamski P, Chełmicki Z, Chełmicki A, Pałucha A, Heczko PB. Studies on the effects of probiotic Lactobacillus mixture given oraly on vaginal and rectal colonization and on parameters of vaginal health in women with intermediate vaginal flora. Eur J Obstet Gynecol Reprod Biol. 2012;163:2:210-215.  https://doi.org/10.1016/j.ejogrb.2012.05.001
  23. Köhler GA, Assefa S, Reid G. Probiotic interference of Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 with the opportunistic fungal pathogen Candida albicans. Infect Dis Obstet Gynecol. 2012:636474. https://doi.org/10.1155/2012/636474
  24. Chew SY, Cheah YK, Seow HF, Sandai D, Than LT. Probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 exhibit strong antifungal effects against vulvovaginal candidiasis-causing Candida glabrata isolates. J Appl Microbiol. 2015;118:5:1180-1190. https://doi.org/10.1111/jam.12772
  25. Houttu N, Mokkala K, Saleem WT, Virtanen S, Juhila J, Koivuniemi E, Pellonperä O, Tertti K, Luokola P, Sorsa T, Salonen A, Lahti L, Laitinen K. Potential pathobionts in vaginal microbiota are affected by fish oil and/or probiotics intervention in overweight and obese pregnant women. Biomed Pharmacother. 2022;149:112841. https://doi.org/10.1016/j.biopha.2022.112841
  26. Deng Y, Wu L, Liu Y. Probiotics for preventing gestational diabetes in overweight or obese pregnant women: A review. World J Clin Cases. 2022;10:36:13189-13199. https://doi.org/10.12998/wjcc.v10.i36.13189
  27. Ho M, Chang YY, Chang WC, Lin HC, Wang MH, Lin WC, Chiu TH. Oral Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 to reduce Group B Streptococcus colonization in pregnant women: A randomized controlled trial. Taiwan J Obstet Gynecol. 2016;55:4:515-518.  https://doi.org/10.1016/j.tjog.2016.06.003
  28. Liu Y, Huang Y, Cai W, Li D, Zheng W, Xiao Y, Liu Y, Zhao H, Pan S. Effect of oral Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 on vaginal Group B Streptococcus colonization and vaginal microbiome in late pregnancy. Nan Fang Yi Ke Da Xue Xue Bao. 2020;40:12:1753-1759. https://doi.org/10.12122/j.issn.1673-4254.2020.12.09
  29. Radzinskii VE, Manukhin IB, Ordiyants IM, Balan VE, Tikhomirova EV, Sakhaudinova IV, Zulkarneeva EM. Efficacy of normalization of vaginal microbiota after antimicrobial treatment for bacterial vaginosis and bacterial vaginosis in pregnant women (results of the multicenter prospective non-interventional comparative study). RMZh. Mat` i ditya. 2021;4:3:192-200. (In Russ.). https://doi.org/10.32364/2618-8430-2021-4-3-192-200
  30. Radzinskii VE, Ordiyants IM, Apresyan SV. Efficiency of vaginal dysbiosis correction in the first trimester of pregnancy. Russian Bulletin of Obstetrician-Gynecologist. 2010;10:3:38-41. (In Russ.).
  31. Novikova SV, Logutova LS, Ignat’eva MA. Clinical evaluation of the efficacy and safety of the use of vagilac to treat bacterial vaginosis in pregnancy. Meditsinskii sovet. 2018;13:90-94. (In Russ.). https://doi.org/10.21518/2079-701X-2018-13-90-94
  32. Petricevic L, Rosicky I, Kiss H, Janjic N, Kaufmann U, Holzer I, Farr A. Effect of vaginal probiotics containing Lactobacillus casei rhamnosus (Lcr regenerans) on vaginal dysbiotic microbiota and pregnancy outcome, prospective, randomized study. Sci Rep. 2023;13:1:7129. https://doi.org/10.1038/s41598-023-34275-9
  33. Yadav J, Das V, Kumar N, Agrawal S, Pandey A, Agrawal A. Vaginal probiotics as an adjunct to antibiotic prophylaxis in the management of preterm premature rupture of the membranes. J Obstet Gynaecol. 2022;42:5:1037-1042. https://doi.org/10.1080/01443615.2021.1993803
  34. Sinyakova AA, Shipitsyna EV, Budilovskaya OV, Bolotskikh VM, Savicheva AM. Anamnestic and microbiological predictors of miscarriage. Zhurnal akusherstva i zhenskikh boleznei. 2019;68:2:59-70. (In Russ.). https://doi.org/10.17816/JOWD68259-70
  35. Choi YS, Kim Y, Hong SY, Cho HJ, Sung JH, Choi SJ, Kim JS, Oh SY, Roh CR. Abnormal vaginal flora in cervical incompetence patients — the Impact of Escherichia coli. Reprod Sci. 2023;3010-3018. https://doi.org/10.1007/s43032-023-01242-8
  36. Gudnadottir U, Debelius JW, Du J, Hugerth LW, Danielsson H, Schuppe-Koistinen I, Fransson E, Brusselaers N. The vaginal microbiome and the risk of preterm birth: a systematic review and network meta-analysis. Sci Rep. 2022;12:1:7926. https://doi.org/10.1038/s41598-022-12007-9
  37. Zhou X, Li XX, Ge YM, Lai SY, Zhou LQ, Feng L, Zhao J. Effects of vaginal microbiota and cervical cerclage on obstetric outcomes of twin pregnancies with cervical incompetence: a retrospective study. Arch Gynecol Obstet. 2022;305:1:77-86.  https://doi.org/10.1007/s00404-021-06119-2
  38. Xiao Y, Huang S, Yu W, Ni Y, Lu D, Wu Q, Leng Q, Yang T, Ni M, Xie J, Zhang X. Effects of emergency/nonemergency cervical cerclage on the vaginal microbiome of pregnant women with cervical incompetence. Front Cell Infect Microbiol. 2023;13:1072960. https://doi.org/10.3389/fcimb.2023.1072960
  39. Tapil’skaya NI, Savicheva AM, Shipitsyna EV. Lactoginal for correction of abnormal vaginal microbiocenosis in pregnant woman with cervical cerclage: clinical case and literature review. Zhurnal akusherstva i zhenskikh boleznei. 2016;65:6:89-95. (In Russ.). https://doi.org/10.17816/JOWD65689-95
  40. Stojanovic N, Plecas D, Plesinac S. Normal vaginal flora, disorders and application of probiotics in pregnancy. Arch Gynecol Obstet. 2012;286:2:325-332.  https://doi.org/10.1007/s00404-012-2293-7
  41. Council of Experts «Science and practice in the field of probiotics in obstetrics and gynecology». Akusherstvo i ginekologiya: novosti, mneniya, obuchenie. 2021;9:2:68-81. (In Russ.). https://doi.org/10.33029/2303-9698-2021-9-2-68-81
  42. Vargas M, Yanez F, Elias A, Bernabeu A, Goya M, Xie Z, Farras A, Sanchez O, Soler Z, Blasquez C, Valle L, Olivella A, Munoz B, Brik M, Carreras E, Manichanh C. Cervical pessary and cerclage placement for preterm birth prevention and cervicovaginal microbiome changes. Acta Obstet Gynecol Scand. 2022;101:12:1403-1413. https://doi.org/10.1111/aogs.14460
  43. Brown RG, Chan D, Terzidou V, Lee YS, Smith A, Marchesi JR, MacIntyre DA, Bennett PR. Prospective observational study of vaginal microbiota pre- and post-rescue cervical cerclage. BJOG. 2019;126:7:916-925.  https://doi.org/10.1111/1471-0528.15600
  44. Fang J, Chen L, Chen Z, Jiang X, Pan M. Association of the vaginal microbiota with pregnancy outcomes in Chinese women after cervical cerclage. Reprod Biomed Online. 2020;41:4:698-706.  https://doi.org/10.1016/j.rbmo.2020.06.016

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