OBJECTIVE

Evaluation of the content of progesterone, placental lactogen and estriol in the blood serum of pregnant women with varicose veins of the genitals in the II and III trimesters of pregnancy.

MATERIAL AND METHODS

A study was conducted in the blood serum of progesterone, estriol and placental lactogen levels at 28—32 and 38—39 weeks of gestation in 55 pregnant women, who were divided into 2 groups: 35 pregnant women with genital varicose veins of the and 20 healthy pregnant women.

RESULTS

The study found that pregnant women genital with varicose veins of the have a decrease in the level of progesterone and placental lactogen in relation to the gestational reference data, in contrast to the group of pregnant women without genital varicose veins. Instability of free estriol concentration was noted, since compared to the norm it remained elevated at 28—32 weeks, and at 38—39 weeks its level increased significantly, which was statistically significant in relation to this indicator in the group of pregnant women without genital varicose veins (p<0.05). Determination of the types of hormonal reactions showed that — in 15 (42.8%) pregnant women with genital varicose veins, the hormonal function of the fetoplacental complex was pathological, normal — in 12 (34%) and increased — in 8 (22.8%) pregnant women.

CONCLUSION

By the end of pregnancy, the adaptive reserves of the fetoplacental complex in patients with genital varicose veins are statistically significantly lower than in healthy pregnant women without it.