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Klimova I.V.

V.I. Krasnopolsky Moscow Regional Scientific Research Institute of Obstetrics and Gynecology

Yarygina T.A.

V.I. Krasnopolsky Moscow Regional Research Institute of Obstetrics and Gynecology

Efimkova E.B.

V.I. Krasnopolsky Moscow Regional Scientific Research Institute of Obstetrics and Gynecology

Shakaya M.N.

V.I. Krasnopolsky Moscow Regional Scientific Research Institute of Obstetrics and Gynecology

Shmakov R.G.

V.I. Krasnopolsky Moscow Regional Research Institute of Obstetrics and Gynecology

Multidisciplinary aspects of pregnancy management in maternal cancer and fetal malformations

Authors:

Klimova I.V., Yarygina T.A., Efimkova E.B., Shakaya M.N., Shmakov R.G.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2025;25(6): 69‑76

DOI: 10.17116/rosakush20252506169

Read: 641 times

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Table of contents

MULTIDISCIPLINARY ASPECTS OF PREGNANCY MANAGEMENT IN MATERNAL CANCER AND FETAL MALFORMATIONS
MULTIDISCIPLINARY ASPECTS OF PREGNANCY MANAGEMENT IN MATERNAL CANCER AND FETAL MALFORMATIONS

To cite this article:

Klimova IV, Yarygina TA, Efimkova EB, Shakaya MN, Shmakov RG. Multidisciplinary aspects of pregnancy management in maternal cancer and fetal malformations. Russian Bulletin of Obstetrician-Gynecologist. 2025;25(6):69‑76. (In Russ.)
https://doi.org/10.17116/rosakush20252506169

Подписка 2026 Российский вестник акушера-гинеколога (Russian Bulletin of Obstetrician-Gynecologist)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The frequency of detection of malignant neoplasms in pregnant patients has been steadily increasing in recent years. The management of patients with this pathology raises many questions, including the potential for negative effects on the fetus of both the oncological process itself and diagnostic technologies and treatment protocols prescribed to the mother. The combination of cancer and pregnancy is a complex problem that requires an interdisciplinary approach involving doctors of various specialties, from oncologists, surgeons, chemotherapists to obstetricians and gynecologists, geneticists, and psychotherapists. The paper presents a unique clinical case with pathological conditions diagnosed during pregnancy in the mother and fetus: breast cancer in the pregnant woman, craniosynostosis in combination with heterozygous variants in the CDC42BPB and RPS6KA3 genes in the fetus. Due to the high level of antenatal ultrasound diagnostics at the third-level institution and successful inter-clinical cooperation, it was possible to develop optimal tactics for managing pregnancy and childbirth, as well as provide timely specialized treatment for the mother and newborn. The article draws attention to the urgent need to improve the quality of outpatient examination and screening stages of prenatal fetal examination, as well as the development of an individualized multidisciplinary approach to the management of cancer patients diagnosed during pregnancy, aimed at maximizing the effectiveness of treatment, increasing the duration and quality of life for both patients.

Keywords:

breast cancer
pregnancy
congenital malformations of the fetus
craniosynostosis
prenatal diagnosis
exome sequencing

Authors:

Klimova I.V.

V.I. Krasnopolsky Moscow Regional Scientific Research Institute of Obstetrics and Gynecology

Yarygina T.A.

V.I. Krasnopolsky Moscow Regional Research Institute of Obstetrics and Gynecology

Efimkova E.B.

V.I. Krasnopolsky Moscow Regional Scientific Research Institute of Obstetrics and Gynecology

Shakaya M.N.

V.I. Krasnopolsky Moscow Regional Scientific Research Institute of Obstetrics and Gynecology

Shmakov R.G.

V.I. Krasnopolsky Moscow Regional Research Institute of Obstetrics and Gynecology

Received:

12.12.2024

Accepted:

10.01.2025

Close metadata

References:

  1. Wu P, Jordan KP, Chew-Graham CA, Mohamed MO, Barac A, Lundberg GP. In-Hospital complications in pregnant women with current or historical cancer diagnoses. Mayo Clinic Proceedings. 2021;96:2779-2792. https://doi.org/10.1016/j.mayocp.2021.03.038
  2. Ma KK, Monsell SE, Chandrasekaran S, Gadi VK, Gammill HS. Cancer and pregnancy: National trends. Am J Perinatol. 2022; 39:144-153.  https://doi.org/10.1055/s-0040-1714394
  3. Petkau VV, Kiseleva KE, Kiselev EA, Efremov SA, Ankudinov NO, Karimova AA. Malignant neoplasms associated with pregnancy: a population-based study. Zlokachestvennye opukholi. 2023;13:1:5-10. (In Russ.). https://doi.org/10.18027/2224-5057-2023-13-1-5-10
  4. Pavlidis NA. Coexistence of pregnancy and malignancy. Oncologist. 2002;7:279-287.  https://doi.org/10.1634/theoncologist.2002-0279
  5. Hepner A, Negrini D, Hase EA, Exman P, Testa L, Trinconi AF. Filassi JR, Francisco RPV, Zugaib M, O’Connor TL, Martin MG. Cancer during pregnancy: The Oncologist overview. World J Oncol. 2019;10:28-34.  https://doi.org/10.14740/wjon1177
  6. Volochaeva MV, Polushkina ES, Shmakov RG, Shetikova OV. Pregnancy management in women with cancer (10 years of experience). Akusherstvo i ginekologiya. 2012;6:92-98. (In Russ.).
  7. Paraconnaya AA. Breast cancer and pregnancy. Zlokachestvennye opukholi. 2015;2:7-14. (In Russ.).
  8. Shmakov RG, Akhmedova AI, Polushkina ES, Demina EA, Mangasarova YaK, Tumyan GS. Modern principles of pregnancy management in patients with lymphomas. Akusherstvo i ginekologiya. 2019;7:40-48. (In Russ.). https://doi.org/10.18565/aig.2019.7.40-48
  9. Walters B, Midwinter I, Chew-Graham CA, Jordan KP, Sharma G, Chappell LC, Crosbie EJ, Parwani P, Mamas MA, Wu P. Pregnancy-associated cancer: A Systematic review and meta-analysis. Mayo Clin Proc Innov Qual Outcomes. 2024;8:188-199.  https://doi.org/10.1016/j.mayocpiqo.2024.02.002
  10. Auger N, Maniraho A, Ayoub A, Arbour L. Association of maternal cancer with congenital anomalies in offspring. Paediatr Perinat Epidemiol. 2024;38:121-129.  https://doi.org/10.1111/ppe.13031
  11. Momen N, Ernst A, Arendt LH, Olsen J, Li J, Gissler M. Maternal cancer and congenital anomalies in children — a Danish nationwide cohort study. PLOS One. 2017;12:e0173355. https://doi.org/10.1371/journal.pone.0173355
  12. Toure AI, Bathily YCD, Mihimit A, Ba M, Cherif H, Keita M, Balde S, Traore B. Breast cancer and pregnancy: Epidemiology and prognosis. Gynecol Reprod Health. 2024;8:2:1-6.  https://doi.org/10.33425/2639-9342.1243
  13. Berretta M, Buonomo OC, Vanni G, Facchini BA. Breast cancer updates. chapter: Breast cancer and pregnancy: Epidemiology, phenotypes, presentation during pregnancy, and therapeutic approaches. Intech Open. 2023;306.  https://doi.org/10.5772/intechopen.109344
  14. The UK breast cancer in pregnancy (UKBCiP) Study. Incidence, diagnosis, management and short-term outcomes of breast cancer first diagnosed during pregnancy in the United Kingdom: A population-based descriptive study. NIHR Open Res. 2024;4:40-57.  https://doi.org/10.3310/nihropenres.13652.1
  15. Ter-Ovanesov MD, Shal’ EP, Kukosh MYu, Oganisyan AN. Breast cancer during pregnancy: diagnosis, treatment, prognosis. Meditsinskii alfavit. 2018;2:29:10-16. (In Russ.). https://www.med-alphabet.com/jour/article/view/756
  16. Matos APE, Ovcaricek T. Breast cancer during pregnancy: Retrospective institutional case series. Radiol Oncol. 2021;55:3:362-368.  https://doi.org/10.2478/raon-2021-0022
  17. Dobrokhotova YuE, Borovkova EI, Arutyunyan AM. Pregnancy-associated breast cancer. Russian Bulletin of Obstetrician-Gynecologist. 2019;19:4:77-81. (In Russ.). https://doi.org/10.17116/rosakush20191904177
  18. Amant F, Lefrère H, Borges VF, Cardonick E, Lambertini M, Loibl S. The definition of pregnancy-associated breast cancer is outdated and should no longer be used. Lancet Oncol. 2021;22:753-754.  https://doi.org/10.1016/S1470-2045(21)00183-2
  19. Loibl S, Schmidt A, Gentilini O, Kaufman B, Kuhl C, Denkert C. Breast cancer diagnosed during pregnancy: Adapting recent advances in breast cancer care for pregnant patients. JAMA Oncol. 2015;1:1145-1153. https://doi.org/10.1001/jamaoncol.2015.2413
  20. Pauker VA, Shmakov RG. Oncological diseases and pregnancy. Akusherstvo i ginekologiya. 2013;11:13-18. (In Russ.). https://aig-journal.ru/articles/Onkologicheskie-zabolevaniya-i-beremennost.html
  21. Rojas KE, Bilbro N, Manasseh D-M, Borgen PI. A Review of pregnancy-associated breast cancer: Diagnosis, local and systemic treatment, and prognosis. J Women’s Health. 2019;28:778-784.  https://doi.org/10.1089/jwh.2018.7264
  22. Martínez MT, Bermejo B, Hernando C, Gambardella V, Cejalvo JM, Lluch A. Breast cancer in pregnant patients: A review of the literature. Eur J Obstet Gynecol Reprod Biol. 2018;230:222-227.  https://doi.org/10.1016/j.ejogrb.2018.04.029
  23. Reyes E, Xercavins N, Saura C, Espinosa-Bravo M, Gil-Moreno A, Cordoba O. Breast cancer during pregnancy: matched study of diagnostic approach, tumor characteristics, and prognostic factors. Tumori. 2020;106:378-387.  https://doi.org/10.1177/0300891620925158
  24. Alghamdi SA. Gadolinium-Based Contrast Agents in Pregnant Women: A Literature review of MRI safety. Cureus. 2023;15:e38493. https://doi.org/10.7759/cureus.38493
  25. Copel J, El-Sayed Y, Heine RP, Wharton KR. Committee Opinion No. 723: Guidelines for diagnostic imaging during pregnancy and lactation. Obstet Gynecol. 2017;130:e210—e216. https://doi.org/10.1097/aog.0000000000002355
  26. Cardoso F, Kyriakides S, Ohno S, Penault-Llorca F, Poortmans P, Rubio IT. Early breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2019;30:1194-1220. https://doi.org/10.1093/annonc/mdz173
  27. Boere I, Lok C, Poortmans P, Koppert L, Painter R, Heuvel-Eibrink MMVd, Amant F. Breast cancer during pregnancy: epidemiology, phenotypes, presentation during pregnancy and therapeutic modalities. Best Pract Res Clin Obstet Gynaecol. 2022;82:46-59.  https://doi.org/10.1016/j.bpobgyn.2022.05.001
  28. Fazeli S, Sakala M, Rakow-Penner R, Ojeda-Fournier H. Cancer in pregnancy: breast cancer. Abdominal Radiol. 2023;48:1645-1662. https://doi.org/10.1007/s00261-023-03824-1
  29. Zakharova NV, Tereshin OS, Bulynskii DN, Udovichenko IV, Samylov VV, Vazhenina II, Korostelev AM, Shmidt AV, Okhitina EO, Borovinskikh MI. Breast cancer associated with pregnancy. Ural’skii meditsinskii zhurnal. 2021;20:2:75-79. (In Russ.). https://doi.org/10.52420/2071-5943-2021-20-2-75-79
  30. Amant F, Nekljudova V, Maggen Ch, Seither F, Neven P, Cardonick E. Outcome of breast cancer patients treated with chemotherapy during pregnancy compared with non-pregnant controls. J Clin Oncol. 2021;39:515.  https://doi.org/10.1200/JCO.2021.39.15_suppl.515
  31. Nguyen B, Venet D, Azim HA, Brown D, Desmedt C, Lambertini M. Breast cancer diagnosed during pregnancy is associated with enrichment of non-silent mutations, mismatch repair deficiency signature and mucin mutations. NPJ Breast Cancer. 2018;4:1-7.  https://doi.org/10.1038/s41523-018-0077-3
  32. De la Haba-Rodríguez JR, Mínguez P, Rojo F, Martín M, Alba E, Servitja S. Gestational breast cancer: distinctive molecular and clinico-epidemiological features. J Mammary Gland Biol Neoplasia. 2024;29:18.  https://doi.org/10.1007/s10911-024-09571-3
  33. Volochaeva MV, Shmakov RG, Parakonnaya AA. The management strategy for pregnancy in cases of breast cancer. Akusherstvo i ginekologiya: novosti, mneniya, obuchenie. 2014;2:39-42. (In Russ.).
  34. Dobrokhotova YuE, Borovkova EI, Zalesskaya SA, Arutyunyan AM, Borovkov IM. Chemotherapy during pregnancy: opportunities and risks. Russian Bulletin of Obstetrician-Gynecologist. 2019;19:3:81-85. (In Russ.). https://doi.org/10.17116/rosakush20191903181
  35. van Gerwen M, Maggen C, Cardonick E, Verwaaijen EJ, van den Heuvel-Eibrink M, Shmakov RG, Boere I, Gziri MM, Ottevanger PB, Lok CAR, Halaska M, Shao LT, Struys I, van Dijk-Lokkart EM, Van Calsteren K, Fruscio R, Zola P, Scarfone G, Amant F; International Network on Cancer, Infertility and Pregnancy. Association of chemotherapy timing in pregnancy with congenital malformation. JAMA Netw Open. 2021;4:e2113180. https://doi.org/10.1001/jamanetworkopen.2021.13180
  36. Serov VN, Shmakov RG, Polushkina ES, Volochaeva MV. Cancer and pregnancy. Russkii meditsinskii zhurnal. 2015;20:1195-1197. (In Russ.).
  37. de Haan J, Verheecke M, Van Calsteren K, Van Calster B, Shmakov RG, Gziri MM, Halaska MJ, Fruscio R, Lok CAR, Boere IA, Zola P, Ottevanger PB, de Groot CJM, Peccatori FA, Steffensen KD, Cardonick EH, Polushkina E, Rob L, Ceppi L, Sukhikh GT, Han SN, F Amant; International Network on Cancer and Infertility Pregnancy (INCIP). Oncological management and obstetric and neonatal outcomes for women diagnosed with cancer during pregnancy: a 20-year international cohort study of 1170 patients. Lancet Oncol. 2018;19:337-346.  https://doi.org/10.1016/S1470-2045(18)30059-7
  38. Maggen C, Wolters VERA, Cardonick E, Fumagalli M, Halaska MJ, Lok CAR, de Haan J, Van Tornout K, Van Calsteren K, Amant F; International Network on Cancer, Infertility and Pregnancy (INCIP). Pregnancy and cancer: the INCIP Project. Curr Oncol Reports. 2020;22:17.  https://doi.org/10.1007/s11912-020-0862-7
  39. Swanson J, Oppenheimer A, Al-Mufarrej F, Pet M, Arakawa C, Cunningham M, Gruss J, Hopper R, Birgfeld C. Maternofetal trauma in craniosynostosis. Plast Reconstr Surg. 2015;136:214e-222e. https://doi.org/10.1097/prs.0000000000001468
  40. Burokas L. Craniosynostosis: Caring for infants and their families. Crit Care Nurse. 2013;33:39-50.  https://doi.org/10.4037/ccn2013678
  41. Vainio HV. Carcinogenesis and teratogenesis may have common mechanisms. Scandinavian J Work, Environment Health. 1989;15:13-17.  https://doi.org/10.5271/sjweh.1889
  42. Spazzapan P, Velnar T. Isolated sagittal craniosynostosis: A Comprehensive review. Diagnostics (Basel). 2024;14:435.  https://doi.org/10.3390/diagnostics14040435
  43. Kague E, Medina-Gomez C, Boyadjiev SA, Rivadeneira F. The genetic overlap between osteoporosis and craniosynostosis. Front Endocrinol. 2022;13:1-17.  https://doi.org/10.3389/fendo.2022.1020821
  44. Stengel K, Zheng Y. Cdc42 in oncogenic transformation, invasion, and tumorigenesis. Cell Signal. 2011;23:1415-1423. https://doi.org/10.1016/j.cellsig.2011.04.001
  45. Chrysanthou E, Gorringe KL, Joseph C, Craze M, Nolan CC, Diez-Rodriguez M, Green AR, Rakha EA, Ellis IO, Mukherjee A. Phenotypic characterisation of breast cancer: the role of CDC42. Breast Cancer Res Treat. 2017;164:317-325.  https://doi.org/10.1007/s10549-017-4267-8
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