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Zalozniaia I.V.

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine

Kopteeva E.V.

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine

Milyutina Yu.P.

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproduction

Korenevsky A.V.

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine

Arutjunyan A.V.

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine

Shelaeva E.V.

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine

Kapustin R.V.

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine

Kogan I.Yu.

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine

Oxidative stress parameters in maternal and umbilical cord blood of pregnant women with gestational and pregestational diabetes mellitus

Authors:

Zalozniaia I.V., Kopteeva E.V., Milyutina Yu.P., Korenevsky A.V., Arutjunyan A.V., Shelaeva E.V., Kapustin R.V., Kogan I.Yu.

More about the authors

Journal: Russian Journal of Human Reproduction. 2025;31(6): 85‑93

DOI: 10.17116/repro20253106185

Read: 595 times

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Table of contents

OXIDATIVE STRESS PARAMETERS IN MATERNAL AND UMBILICAL CORD BLOOD OF PREGNANT WOMEN WITH GESTATIONAL AND PREGESTATIONAL DIABETES MELLITUS
OXIDATIVE STRESS PARAMETERS IN MATERNAL AND UMBILICAL CORD BLOOD OF PREGNANT WOMEN WITH GESTATIONAL AND PREGESTATIONAL DIABETES MELLITUS

To cite this article:

Zalozniaia IV, Kopteeva EV, Milyutina YuP, et al. Oxidative stress parameters in maternal and umbilical cord blood of pregnant women with gestational and pregestational diabetes mellitus. Russian Journal of Human Reproduction. 2025;31(6):85‑93. (In Russ.)
https://doi.org/10.17116/repro20253106185

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

INTRODUCTION

Pregnancy complicated by diabetes mellitus (DM) is associated with a high risk of adverse perinatal outcomes (prematurity, diabetic fetopathy). These complications are caused by chronic intrauterine fetal hypoxia associated with the enhancement of oxidative stress. Imbalance between reactive oxygen species production and the activity of the antioxidant system plays an important role in the pathogenesis of various DM types during pregnancy.

OBJECTIVE

The aim of this study was to evaluate oxidative stress markers in pregnant women with pre-pregnancy DM (PGDM) type 1 or 2, with gestational diabetes mellitus (GDM), and in the control group without hyperglycemia at 37-41 weeks of pregnancy; as well as to assess the severity of oxidative stress depending on the DM type.

MATERIALS AND METHODS

3-Nitrotyrosine and malondialdehyde levels, catalase and total antiradical activities were determined in the maternal and cord blood serum of 94 pregnant women. The serum concentration of 3-nitrotyrosine was measured using the ELISA method; malondialdehyde level, catalase activity, and antiradical activity were measured by colorimetric methods.

RESULTS

Increased 3-nitrotyrosine and malondialdehyde levels were observed in the PGDM group compared to the other study groups (GDM and control groups). Total antiradical activity increased in the PGDM and GDM groups, catalase activity not changing in all the study groups.

CONCLUSIONS

DM during pregnancy is associated with the enhancement of oxidative stress, which can lead to the development of adverse perinatal outcomes. Moreover, patients with PGDM showed activation of oxidative stress that was more pronounced compared to the control group and the group of patients with GDM.

Keywords:

diabetes mellitus
pregnancy
oxidative stress
nitrotyrosine
malondialdehyde
catalase
total antiradical activity

Authors:

Zalozniaia I.V.

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine

Kopteeva E.V.

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine

Milyutina Yu.P.

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproduction

Korenevsky A.V.

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine

Arutjunyan A.V.

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine

Shelaeva E.V.

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine

Kapustin R.V.

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine

Kogan I.Yu.

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductive Medicine

Received:

21.07.2024

Accepted:

12.11.2024

Close metadata

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